Search Results - "FURMAN, Mark I"

Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction by Furman, Mark I, Barnard, Marc R, Krueger, Lori A, Fox, Marsha L, Shilale, Elizabeth A, Lessard, Darleen M, Marchese, Peter, Frelinger, A.L, Goldberg, Robert J, Michelson, Alan D

“…OBJECTIVES We investigated whether elevated levels of circulating monocyte-platelet aggregates (MPA) can be used to identify patients with acute myocardial…”
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Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization by Furman, Mark I, Krueger, Lori A, Linden, Matthew D, Barnard, Marc R, Frelinger, Andrew L, Michelson, Alan D

“…The purpose of this study was to examine the effects of glycoprotein (GP) IIb/IIIa antagonists (abciximab, eptifibatide, and tirofiban) and other inhibitors on…”
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The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin by Frelinger, 3rd, Andrew L, Jakubowski, Joseph A, Li, Youfu, Barnard, Marc R, Fox, Marsha L, Linden, Matthew D, Sugidachi, Atsuhiro, Winters, Kenneth J, Furman, Mark I, Michelson, Alan D

“…The novel thienopyridine prodrug prasugrel, a platelet P2Y(12) ADP receptor antagonist, requires in vivo metabolism for activity. Although pharmacological data…”
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An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates by Marciniak, Jr, Stanley J, Mascelli, Mary A, Furman, Mark I, Michelson, Alan D, Jakubowski, Joseph A, Jordan, Robert E, Marchese, Peter J, Frelinger, Andrew L

“…The ability of abciximab to prevent fibrinogen binding to activated platelets indicates it may also promote dissolution of platelet-rich thrombi. The present…”
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Current Options in Platelet Function Testing by Michelson, Alan D., Frelinger, Andrew L., Furman, Mark I.

“…The variable response to antiplatelet therapy has led to the use of platelet function tests to monitor the effects of antiplatelet drugs in cardiovascular…”
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Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization by Frelinger, 3rd, Andrew L, Li, YouFu, Linden, Matthew D, Barnard, Marc R, Fox, Marsha L, Christie, Douglas J, Furman, Mark I, Michelson, Alan D

“…Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1…”
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Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1-and cyclooxygenase-2-independent pathway : A 700-patient study of aspirin resistance by FRELINGER, Andrew L, FURMAN, Mark I, LINDEN, Matthew D, YOUFU LI, FOX, Marsha L, BARNARD, Marc R, MICHELSON, Alan D

“…Thrombotic events still occur in aspirin-treated patients with coronary artery disease. To better understand aspirin "resistance," serum thromboxane B2 (TXB2)…”
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Measuring antiplatelet drug effects in the laboratory by Harrison, Paul, Frelinger, A.L, Furman, Mark I, Michelson, Alan D

“…Abstract This review discusses the advantages and disadvantages of currently available tests for the monitoring of antiplatelet therapy (especially aspirin and…”
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Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin : Studies in baboons, human coronary intervention, and human acute myocardial infarction by MICHELSON, Alan D, BARNARD, Marc R, KRUEGER, Lori A, VALERI, C. Robert, FURMAN, Mark I

“…Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate…”
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The influence of intermittent hypoxemia on platelet activation in obese patients with obstructive sleep apnea by Rahangdale, Shilpa, Yeh, Susie Yim, Novack, Victor, Stevenson, Karen, Barnard, Marc R, Furman, Mark I, Frelinger, Andrew L, Michelson, Alan D, Malhotra, Atul

“…Literature regarding platelet function in obstructive sleep apnea (OSA) has considerable limitations. Given the central role of platelets in atherothrombosis…”
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The Cleaved Peptide of the Thrombin Receptor is a Strong Platelet Agonist by Furman, Mark I., Liu, Longbin, Benoit, Stephen E., Becker, Richard C., Barnard, Marc R., Michelson, Alan D.

“…Thrombin cleaves its G-protein-linked seven-transmembrane domain receptor, thereby releasing a 41-aa peptide and generating a new amino terminus that acts as a…”
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Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists by Michelson, A D, Furman, M I, Goldschmidt-Clermont, P, Mascelli, M A, Hendrix, C, Coleman, L, Hamlington, J, Barnard, M R, Kickler, T, Christie, D J, Kundu, S, Bray, P F

“…Both inherited predisposition and platelet hyperreactivity have been associated with ischemic coronary events, but mechanisms that support genetic differences…”
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Twenty-two year (1975 to 1997) trends in the incidence, in-hospital and long-term case fatality rates from initial q-wave and non-q-wave myocardial infarction: a multi-hospital, community-wide perspective by Furman, Mark I, Dauerman, Harold L, Goldberg, Robert J, Yarzbeski, Jorge, Lessard, Darleen, Gore, Joel M

“…OBJECTIVES The goal of this study was to examine long-term trends in the incidence, in-hospital and long-term mortality patterns in patients with an initial…”
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'Postconditioning' the human heart: multiple balloon inflations during primary angioplasty may confer cardioprotection by Darling, Chad E, Solari, Patrick B, Smith, Craig S, Furman, Mark I, Przyklenk, Karin

“…Growing evidence from experimental models suggests that relief of myocardial ischemia in a stuttering manner (i.e., 'postconditioning' [PostC] with brief…”
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Increased Platelet Reactivity and Circulating Monocyte-Platelet Aggregates in Patients With Stable Coronary Artery Disease by Furman, Mark I, Benoit, Stephen E, Barnard, Marc R, Valeri, C.Robert, Borbone, Marie L, Becker, Richard C, Hechtman, Herbert B, Michelson, Alan D

“…Objectives. We sought to examine whether patients with stable coronary artery disease (CAD) have increased platelet reactivity and an enhanced propensity to…”
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Evaluation of Platelet Function by Flow Cytometry by Michelson, Alan D., Barnard, Marc R., Krueger, Lori A., Frelinger, A.L., Furman, Mark I.

“…Platelet function in whole blood can be comprehensively evaluated by flow cytometry. Flow cytometry can be used to measure platelet reactivity, circulating…”
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Application of flow cytometry to platelet disorders by Linden, Matthew D, Frelinger, 3rd, Andrew L, Barnard, Marc R, Przyklenk, Karin, Furman, Mark I, Michelson, Alan D

“…Flow cytometry is a powerful and versatile tool that can be used to yield definitive information regarding the phenotypic status of platelets. The method…”
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Leukocytosis and adverse hospital outcomes after acute myocardial infarction by Menon, Vandana, Lessard, Darleen, Yarzebski, Jorge, Furman, Mark I, Gore, Joel M, Goldberg, Robert J

“…An elevated white blood cell (WBC) count at the time of hospital presentation is associated with increased mortality after acute myocardial infarction (AMI)…”
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Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE) by Furman, Mark I, Gore, Joel M, Anderson, Fredrick A, Budaj, Andrzej, Goodman, Shaun G, Avezum, Ávaro, López-Sendón, José, Klein, Werner, Mukherjee, Debabrata, Eagle, Kim A, Dabbous, Omar H, Goldberg, Robert J

“…To examine the association between elevated leukocyte count and hospital mortality and heart failure in patients enrolled in the multinational, observational…”
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The Problem of Persistent Platelet Activation in Acute Coronary Syndromes and Following Percutaneous Coronary Intervention by Braunwald, Eugene, Angiolillo, Dominick, Bates, Eric, Berger, Peter B., Bhatt, Deepak, Cannon, Christopher P., Furman, Mark I., Gurbel, Paul, Michelson, Alan D., Peterson, Eric, Wiviott, Stephen

“…Platelets play a central role in the atherosclerotic inflammatory response, thrombotic vascular occlusion, microembolization, vasoconstriction, and plaque…”
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