Search Results - "FURIC, Luc"

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology by Risbridger, Gail P., Clark, Ashlee K., Porter, Laura H., Toivanen, Roxanne, Bakshi, Andrew, Lister, Natalie L., Pook, David, Pezaro, Carmel J., Sandhu, Shahneen, Keerthikumar, Shivakumar, Quezada Urban, Rosalia, Papargiris, Melissa, Kraska, Jenna, Madsen, Heather B., Wang, Hong, Richards, Michelle G., Niranjan, Birunthi, O’Dea, Samantha, Teng, Linda, Wheelahan, William, Li, Zhuoer, Choo, Nicholas, Ouyang, John F., Thorne, Heather, Devereux, Lisa, Hicks, Rodney J., Sengupta, Shomik, Harewood, Laurence, Iddawala, Mahesh, Azad, Arun A., Goad, Jeremy, Grummet, Jeremy, Kourambas, John, Kwan, Edmond M., Moon, Daniel, Murphy, Declan G., Pedersen, John, Clouston, David, Norden, Sam, Ryan, Andrew, Furic, Luc, Goode, David L., Frydenberg, Mark, Lawrence, Mitchell G., Taylor, Renea A.

“…Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of…”
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Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer by Watt, Matthew J, Clark, Ashlee K, Selth, Luke A, Haynes, Vanessa R, Lister, Natalie, Rebello, Richard, Porter, Laura H, Niranjan, Birunthi, Whitby, Sarah T, Lo, Jennifer, Huang, Cheng, Schittenhelm, Ralf B, Anderson, Kimberley E, Furic, Luc, Wijayaratne, Poornima R, Matzaris, Maria, Montgomery, Magdalene K, Papargiris, Melissa, Norden, Sam, Febbraio, Maria, Risbridger, Gail P, Frydenberg, Mark, Nomura, Daniel K, Taylor, Renea A

“…Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We investigated the role of lipid…”
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Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay by Kim, Yoon Ki, Furic, Luc, DesGroseillers, Luc, Maquat, Lynne E.

“…Mammalian Staufen (Stau)1 is an RNA binding protein that is thought to function in mRNA transport and translational control. Nonsense-mediated mRNA decay (NMD)…”
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AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965 by Dite, Toby A., Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Rebello, Richard J., Ovens, Ashley J., Lindqvist, Lisa M., Ngoei, Kevin R.W., Ling, Naomi X.Y., Furic, Luc, Kemp, Bruce E., Scott, John W., Oakhill, Jonathan S.

“…Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly being investigated for its therapeutic potential in diseases where…”
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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression by Furic, Luc, Rong, Liwei, Larsson, Ola, Koumakpayi, Ismaël Hervé, Yoshida, Kaori, Brueschke, Andrea, Petroulakis, Emmanuel, Robichaud, Nathaniel, Pollak, Michael, Gaboury, Louis A., Pandolfi, Pier Paolo, Saad, Fred, Sonenberg, Nahum, Mak, Tak Wah

“…Translational regulation plays a critical role in the control of cell growth and proliferation. A key player in translational control is eIF4E, the mRNA 5'…”
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YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells by Bai, Yuchen, Gotz, Carolin, Chincarini, Ginevra, Zhao, Zixuan, Slaney, Clare, Boath, Jarryd, Furic, Luc, Angel, Christopher, Jane, Stephen M., Phillips, Wayne A., Stacker, Steven A., Farah, Camile S., Darido, Charbel

“…In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are currently missing. An integrated analysis of patient HNC subtypes using…”
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The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer by Rebello, Richard J, Kusnadi, Eric, Cameron, Donald P, Pearson, Helen B, Lesmana, Analia, Devlin, Jennifer R, Drygin, Denis, Clark, Ashlee K, Porter, Laura, Pedersen, John, Sandhu, Shahneen, Risbridger, Gail P, Pearson, Richard B, Hannan, Ross D, Furic, Luc

“…The MYC oncogene is frequently overexpressed in prostate cancer. Upregulation of ribosome biogenesis and function is characteristic of MYC-driven tumors. In…”
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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly by Gandin, Valentina, Masvidal, Laia, Cargnello, Marie, Gyenis, Laszlo, McLaughlan, Shannon, Cai, Yutian, Tenkerian, Clara, Morita, Masahiro, Balanathan, Preetika, Jean-Jean, Olivier, Stambolic, Vuk, Trost, Matthias, Furic, Luc, Larose, Louise, Koromilas, Antonis E., Asano, Katsura, Litchfield, David, Larsson, Ola, Topisirovic, Ivan

“…Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the…”
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Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases by KONICEK, Bruce W, STEPHENS, Jennifer R, MCCANN, Denis J, PELLETIER, Jerry, FURIC, Luc, YINGLING, Jonathan M, STANCATO, Louis F, SONENBERG, Nahum, GRAFF, Jeremy R, MCNULTY, Ann M, ROBICHAUD, Nathaniel, PEERY, Robert B, DUMSTORF, Chad A, DOWLESS, Michele S, IVERSEN, Philip W, PARSONS, Stephen, ELLIS, Karen E

“…Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation and metastasis. Signaling through the AKT-mTOR pathway activates…”
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mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans by Puelles, Victor G., van der Wolde, James W., Wanner, Nicola, Scheppach, Markus W., Cullen-McEwen, Luise A., Bork, Tillmann, Lindenmeyer, Maja T., Gernhold, Lukas, Wong, Milagros N., Braun, Fabian, Cohen, Clemens D., Kett, Michelle M., Kuppe, Christoph, Kramann, Rafael, Saritas, Turgay, van Roeyen, Claudia R., Moeller, Marcus J., Tribolet, Leon, Rebello, Richard, Sun, Yu B.Y., Li, Jinhua, Müller-Newen, Gerard, Hughson, Michael D., Hoy, Wendy E., Person, Fermin, Wiech, Thorsten, Ricardo, Sharon D., Kerr, Peter G., Denton, Kate M., Furic, Luc, Huber, Tobias B., Nikolic-Paterson, David J., Bertram, John F.

“…The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of…”
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p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs by Petroulakis, Emmanuel, Parsyan, Armen, Dowling, Ryan J.O., LeBacquer, Olivier, Martineau, Yvan, Bidinosti, Michael, Larsson, Ola, Alain, Tommy, Rong, Liwei, Mamane, Yaël, Paquet, Marilene, Furic, Luc, Topisirovic, Ivan, Shahbazian, David, Livingstone, Mark, Costa-Mattioli, Mauro, Teodoro, Jose G., Sonenberg, Nahum

“…eIF4E, the mRNA 5′ cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and…”
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Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium by Wilkinson, Sarah E., Furic, Luc, Buchanan, Grant, Larsson, Ola, Pedersen, John, Frydenberg, Mark, Risbridger, Gail P., Taylor, Renea A.

“…BACKGROUND Contribution of stromal Hedgehog (Hh) signaling is evident in the prostate gland in mice, but needs translation to human tissues if Hh therapeutics…”
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Estrogen receptor β activation impairs prostatic regeneration by inducing apoptosis in murine and human stem/progenitor enriched cell populations by Hussain, Shirin, Lawrence, Mitchell G, Taylor, Renea A, Lo, Camden Yeung-Wah, Frydenberg, Mark, Ellem, Stuart J, Furic, Luc, Risbridger, Gail P

“…Androgen depletion is the primary treatment for prostate disease; however, it fails to target residual castrate-resistant cells that are regenerative and cells…”
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Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis by Dumstorf, Chad A, Konicek, Bruce W, McNulty, Ann M, Parsons, Stephen H, Furic, Luc, Sonenberg, Nahum, Graff, Jeremy R

“…Enzastaurin (LY317615.HCl) is currently in a phase III registration trial for diffuse large B-Cell lymphoma and numerous phase II clinical trials. Enzastaurin…”
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A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer by Toivanen, Roxanne, Furic, Luc

“…PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. https://doi.org/10.1083/jcb.201902048) surprisingly show that…”
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Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity by Takizawa, Itsuhiro, Lawrence, Mitchell G., Balanathan, Preetika, Rebello, Richard, Pearson, Helen B., Garg, Elika, Pedersen, John, Pouliot, Normand, Nadon, Robert, Watt, Matthew J., Taylor, Renea A., Humbert, Patrick, Topisirovic, Ivan, Larsson, Ola, Risbridger, Gail P., Furic, Luc

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Cross-talk between protein synthesis, energy metabolism and autophagy in cancer by Lindqvist, Lisa M, Tandoc, Kristofferson, Topisirovic, Ivan, Furic, Luc

“…•Protein synthesis is one of the most energy consuming processes in the cell.•Nutrient availability modulates growth signaling and protein synthesis…”
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Generally applicable transcriptome-wide analysis of translation using anota2seq by Oertlin, Christian, Lorent, Julie, Murie, Carl, Furic, Luc, Topisirovic, Ivan, Larsson, Ola

“…Abstract mRNA translation plays an evolutionarily conserved role in homeostasis and when dysregulated contributes to various disorders including metabolic and…”
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A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes by Furic, Luc, Maher-Laporte, Marjolaine, DesGroseillers, Luc

“…Messenger RNAs are associated with multiple RNA-binding proteins to form ribonucleoprotein (mRNP) complexes. These proteins are important regulators of the…”
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Regulation of gene expression via translational buffering by Kusnadi, Eric P, Timpone, Clelia, Topisirovic, Ivan, Larsson, Ola, Furic, Luc

“…Translation of an mRNA represents a critical step during the expression of protein-coding genes. As mechanisms governing post-transcriptional regulation of…”
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