Search Results - "FURCHGOTT, R F"

Role of Endothelium in Responses of Vascular Smooth Muscle by Furchgott, Robert F

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Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta by Martin, W, Villani, G M, Jothianandan, D, Furchgott, R F

“…Hemoglobin at 1 microM reduced and at 10 microM abolished the endothelium-dependent relaxation induced by acetylcholine or by A23187 in rabbit aortic rings…”
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The role of endothelium in the responses of vascular smooth muscle to drugs by Furchgott, R F

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Inhibition by sulfhydryl compounds of vascular relaxation induced by nitric oxide and endothelium-derived relaxing factor by Jia, L, Furchgott, R F

“…On rings of rabbit thoracic aorta precontracted with phenylephrine, L-cysteine (Cys) and dithiothreitol (DTT) (1-100 microM), but not glutathione (GSH),…”
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Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor by Martin, W, Furchgott, R F, Villani, G M, Jothianandan, D

“…Removal of endothelial cells on rings of rat aorta increased the sensitivity to the selective alpha-1 adrenoceptor agonist phenylephrine, to the nonselective…”
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Interactions of light and sodium nitrite in producing relaxation of rabbit aorta by Matsunaga, K, Furchgott, R F

“…In rings of rabbit aorta mounted in muscle chambers, endothelial-independent reversible relaxation produced by irradiation with long wavelength was potentiated…”
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The 1989 Ulf von Euler lecture. Studies on endothelium-dependent vasodilation and the endothelium-derived relaxing factor by Furchgott, R F

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Responses of rabbit aorta to nitric oxide and superoxide generated by ultraviolet irradiation of solutions containing inorganic nitrite by Matsunaga, K, Furchgott, R F

“…In a perfusion-superfusion system, an endothelium-free ring of rabbit thoracic aorta precontracted with phenylephrine was used to bioassay relaxing activity…”
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Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor by Martin, W, Furchgott, R F, Villani, G M, Jothianandan, D

“…The selective cyclic GMP phosphodiesterase inhibitor M&B 22948 and the less selective phosphodiesterase inhibitors papaverine and isobutylmethylxanthine (IBMX)…”
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Role of Endothelial Cells in Relaxation of Isolated Arteries by Bradykinin by Cherry, Peter D., Furchgott, Robert F., Zawadzki, John V., Jothianandan, Desingarao

“…Bradykinin elicits relaxation of isolated transverse rings of canine coronary, celiac, superior mesenteric, renal, splenic, pulmonary, gastric, and femoral…”
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Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins by Martin, W, Villani, G M, Jothianandan, D, Furchgott, R F

“…We have reported previously that hemoglobin inhibits endothelium-dependent and glyceryl trinitrate-induced relaxation in the rabbit aorta. In this study we…”
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Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide by Furchgott, R F

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Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light by Furchgott, R F, Jothianandan, D

“…The characteristics of carbon monoxide (CO)-induced, endothelium-independent relaxation of rabbit aorta were compared with those of nitric oxide (NO)-induced…”
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Endothelium-derived relaxing and contracting factors by Furchgott, R F, Vanhoutte, P M

“…Endothelium-dependent relaxation of blood vessels is produced by a large number of agents (e.g., acetylcholine, ATP and ADP, substance P, bradykinin,…”
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Endothelial cells as mediators of vasodilation of arteries by Furchgott, R F, Cherry, P D, Zawadzki, J V, Jothianandan, D

“…A brief review is first presented of findings during the past few years by the authors and by others on the nonprostaglandin endothelium-dependent relaxation…”
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Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta by Besse, J C, Furchgott, R F

“…The dissociation constants (KA values) of l-norepinephrine (l-NE) and seven other agonists acting on alpha adrenergic receptors in rabbit aorta strips were…”
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Use of selective antagonists for determining the types of receptors mediating the actions of 5-hydroxytryptamine and tryptamine in the isolated rabbit aorta by Stollak, J S, Furchgott, R F

“…Competitive and noncompetitive antagonists were used to study the receptors which mediate the contraction elicited by 5-hydroxytryptamine (5-HT) and tryptamine…”
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Evidence for endothelium-dependent vasodilation of resistance vessels by acetylcholine by Furchgott, R F, Carvalho, M H, Khan, M T, Matsunaga, K

“…In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of…”
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A research trail over half a century by Furchgott, R F

“…The author describes his major research activities from the time of his PhD thesis work (1937-1940) on properties of erythrocyte membranes to the present. His…”
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Nitric oxide: from basic research on isolated blood vessels to clinical relevance in diabetes by Furchgott, R F

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