Search Results - "FUKUSHIMA, Kiyomi"

Identification of Human Cytochrome P-450 Isoforms Involved in Metabolism of R(+)- and S(−)-Gallopamil: Utility of In Vitro Disappearance Rate by SUZUKI, A, IIDA, I, TANAKA, F, AKIMOTO, M, FUKUSHIMA, K, TANI, M, ISHIZAKI, T, CHIBA, K

“…Isoforms of cytochrome P-450 (CYP) involved in the metabolism of gallopamil enantiomers were identified by measuring the disappearance rate of parent drug from…”
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Ultrasensitive determination of NE-100, a novel sigma ligand, in human plasma by liquid chromatography and electrospray ionization tandem mass spectrometry combined with a column-switching technique by Yamaguchi, Jun-ichi, Watanabe, Yumiko, Ohmichi, Mari, Jingu, Shigeji, Ogawa, Naoyoshi, Kokatsu, Jun, Fukushima, Kiyomi, Goto, Junichi

“…For the highly sensitive and selective determination of NE-100, a novel sigma ligand, at levels of low picogram per milliliter of human plasma, a method with…”
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Retention Mechanism of Imidazoles in Connective Tissue. IV. Identification of a Nucleophilic imidazolone Metabolite in Rats by OHTA, Katsuji, FUKASAWA, Yoshiki, YAMAGUCHI, Jun-ichi, KOHNO, Yoshiro, FUKUSHIMA, Kiyomi, SUWA, Toshio, AWAZU, Shoji

“…Formation of a nucleophilic 4(5H)(or 5(4H))-imidazolone structure has been postulated from in vitro studies to be one of the causative elements involved in the…”
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Retention Mechanism of Imidazoles in Connective Tissue. III. Aldehyde Adduct Formation of a 4(5H)(or 5(4H))-Imidazolone Product in Vitro by OHTA, Katsuji, FUKASAWA, Yoshiki, YAMAGUCHI, Jun-ichi, AKIMOTO, Masayuki, KOHNO, Yoshiro, FUKUSHIMA, Kiyomi, SUWA, Toshio, AWAZU, Shoji

“…2-Methylimidazole (2MI), as well as imidazole, has been though to undergo cupro-ascorbate (Cu-VC)-catalyzed oxidative transformation in vitro to become a…”
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Relationship between the Metabolic Chiral Inversion and Chemical Structure of 4-Phenyl-4-oxobutanoic Acids, Derivatives of Anti-rheumatic Agent KE-298 by YOSHIDA, Hideo, KOHNO, Yoshiro, ENDO, Hiromi, FUKUSHIMA, Kiyomi, SUWA, Toshio, HAYASHI, Masahiro

“…The relationship between metabolic chiral inversion and chemical structure of various 4-phenyl-4-oxobutanoic acids (4-OBA), derivatives of anti-rheumatic agent…”
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Purification and Characterization of Glutathione-Independent Denitration Enzyme of Organic Nitrate Esters in Rabbit Hepatic Cytosol by OGAWA, Naoyoshi, HIROSE, Takuya, TSUKAMOTO, Mayumi, FUKUSHIMA, Kiyomi, SUWA, Toshio, SATOH, Tetsuo

“…The enzyme responsible for glutathione (GSH)-independent denitration of organic nitrate esters was purified by gel chromatography, ion-exchange chromatography…”
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Type IV collagen prevents amyloid β-protein fibril formation by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…The potential of targeting through molecular therapeutics the underlying amyloid β-protein (Aβ) fibrillogenesis causing the initiation and progression of…”
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Gastric pH profiles of beagle dogs and their use as an alternative to human testing by Akimoto, Masayuki, Nagahata, Naokazu, Furuya, Atsushi, Fukushima, Kiyomi, Higuchi, Shohei, Suwa, Toshio

“…Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with…”
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β-amyloid induces caspase-dependent early neurotoxic change in PC12 cells: correlation with H2O2 neurotoxicity by SAITO, Takashi, KIJIMA, Haruko, KIUCHI, Yoichi, ISOBE, Yoshihiko, FUKUSHIMA, Kiyomi

“…We examined neurotoxic effects of Abeta(25-35), an active fragment of beta-amyloid (Abeta), and compared the effect with H2O2 neurotoxicity in PC12 cells…”
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Vasodilating Effect and Tissue Accumulation of Prostaglandin E1 Incorporated in Lipid Microspheres on the Rat Ductus Arteriosus by Chino, Yukihiro, Minagawa, Toshiya, Kohno, Yoshiro, Fukushima, Kiyomi, Momma, Kazuo

“…Prostaglandin E1 incorporated in lipid microspheres (lipo PGE1) was administered to the umbilical vein of neonatal rats. Morphological measurement and…”
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Effect of 2-Methylimidazole on the Mechanical, Biochemical, and Morphological Properties of the Rat Aorta by Its Chronic Treatment along Maturation by OHTA, Katsuji, KOHNO, Yoshiro, FUKUSHIMA, Kiyomi, SUWA, Toshio, AWAZU, Shoji

“…To examine whether the retention of imidazole analogues in the organ rich with elastic connective tissue can be of toxicological significance, the effect of…”
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Disassembly of amyloid β-protein fibril by basement membrane components by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi, Kimura, Masaaki

“…Amyloid β-protein (Aβ) fibril in senile plaque may be related to the pathogenesis of Alzheimer's disease (AD). Basement membrane (BM) components are associated…”
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Effect of pibutidine hydrochloride on nitric oxide production in rat gastric mucosa by Kiuchi, Yoichi, Isobe, Yoshihiko, Kijima, Haruko, Higuchi, Shohei, Fukushima, Kiyomi

“…Our previous study have already demonstrated a gastric mucosal protective action of pibutidine hydrochloride (pibutidine), a novel histamine H_2 receptor…”
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Entactin-induced inhibition of human amyloid β-protein fibril formation in vitro by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…Amyloid β-protein (Aβ) fibril in senile plaques may possibly be related to the pathogenesis of Alzheimer's disease (AD). Basement membrane (BM) components are…”
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The effects of haloperidol on action potential parameters of isolated rabbit ventricular muscle by Noguchi, Kazuo, Karasawa, Yasuko, Isobe, Yoshihiko, Fukushima, Kiyomi, Tanaka, Hikaru, Shigenobu, Koki

“…The effects of haloperidol, a typical antipsychotic agent, on action potential parameters of isolated rabbit ventuicular muscles were compared with those of…”
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Influence of Helicobacter pylori infection on healing and recurrence of acetic acid-induced gastric ulcer in Mongolian gerbils by Kijima, Haruko, Kajita, Sumiyo, Isobe, Yoshihiko, Akashi, Toshi, Kimura, Masaaki, Fukushima, Kiyomi

“…Helicobacter pylori (HP) infection induces gastritis and peptic ulcer. We tried to elucidate the influence of HP infection on the healing and recurrence of…”
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Vasodilating Effect and Tissue Accumulation of Prostaglandin E1 Incorporated in Lipid Microspheres on the Rat Ductus Arteriosus by Chino, Yukihiro, Minagawa, Toshiya, Kohno, Yoshiro, Fukushima, Kiyomi, Momma, Kazuo

“…Prostaglandin E1 incorporated in lipid microspheres (lipo PGE1) was administered to the umbilical vein of neonatal rats. Morphological measurement and…”
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β-amyloid induces caspase-dependent early neurotoxic change in PC12 cells: correlation with H 2O 2 neurotoxicity by Saito, Takashi, Kijima, Haruko, Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…We examined neurotoxic effects of Aβ(25–35), an active fragment of β-amyloid (Aβ), and compared the effect with H 2O 2 neurotoxicity in PC12 cells. Aβ(25–35)…”
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Crossed cerebellar diaschisis demonstrated by SPECT in hemiplegic children by Hamano, S, Nara, T, Nozaki, H, Fukushima, K, Imai, M, Kumagai, K, Maekawa, K

“…Crossed cerebellar diaschisis (CCD) in twenty five children with hemiplegia were studied using single photon emission computed tomography (SPECT) with…”
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Changes in Synthetic Activity of Sulfated Mucosubstances in Healing Process of Acetic Acid Ulcer in Rats and Effect of Anti-Ulcer Agents by SUWA, Toshio, FUKUSHIMA, Kiyomi, KYOGOKU, Kazuaki, MORI, Yo

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