Search Results - "FUKUDA, Noboru"

Role of complement 3 in the pathogenesis of hypertension by Chen, Lan, Fukuda, Noboru, Matsumoto, Taro, Abe, Masanori

“…The complement system has recently been reported to contribute to the development and pathogenesis of hypertension, several cardiovascular and renal diseases,…”
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Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 by Otsuki, Tomoyasu, Fukuda, Noboru, Chen, Lan, Tsunemi, Akiko, Abe, Masanori

“…We have demonstrated that complement 3 (C3) is upregulated and induces epithelial-mesenchymal transition (EMT) phenomenon and renal fibrosis in unilateral…”
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5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats by Fukuda, Noboru, Katakawa, Mayumi, Ito, Hidenori, Hara, Takeshi, Otsuka, Noboru, Ishizuka, Masahiro, Abe, Masanori

“…Oral administration of 5-aminolevulinic acid hydrochloride (5-ALA-HCl) has been reported to enhance the hypotensive effects associated with anesthetics,…”
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TWIST1 transcriptionally upregulates complement 3 in glomerular mesangial cells from spontaneously hypertensive rats by Otsuki, Tomoyasu, Fukuda, Noboru, Chen, Lan, Ueno, Takahiro, Otsuki, Masari, Abe, Masanori

“…We have shown that complement 3 (C3) is upregulated in cardiovascular and renal organs, which induces the synthetic phenotype and exaggerates the growth of…”
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Development of gene silencer pyrrole-imidazole polyamides targeting GSK3β for treatment of polycystic kidney diseases by Baba, Seishiro, Fukuda, Noboru, Kobayashi, Hiroki, Tsunemi, Akiko, Akiya, Yurie, Matsumoto, Taro, Abe, Masanori

“…The cyclic adenosine monophosphate (cAMP)–response element binding protein (CREB)–glycogen synthase kinase 3β (GSK3β) signaling pathway was reported to be…”
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Method of Determining Pyrrole–Imidazole Polyamide in Rat Plasma Using Ultra-Fast Liquid Chromatography-Ultraviolet Spectrometry by Miyamoto, Aoi, Yagishita, Kouta, Aoyama, Takahiko, Abe, Masanori, Fukuda, Noboru, Matsumoto, Yoshiaki

“…To improve the efficiency of drug-discovery research on pyrrole–imidazole polyamides (PIs), a more rapid method for quantitative and qualitative measurement of…”
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Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy by Horikoshi, Shu, Fukuda, Noboru, Tsunemi, Akiko, Okamura, Makiyo, Otsuki, Masari, Endo, Morito, Abe, Masanori

“…TGF-β1 has been known to induce diabetic nephropathy with renal fibrosis and glomerulosclerosis. DNA-recognized peptide compound pyrrole-imidazole (PI)…”
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The adrenal gland circadian clock exhibits a distinct phase advance in spontaneously hypertensive rats by Tanaka, Sho, Ueno, Takahiro, Tsunemi, Akiko, Nagura, Chinami, Tahira, Kazunobu, Fukuda, Noboru, Soma, Masayoshi, Abe, Masanori

“…The circadian clock influences a multitude of cellular and biological processes, including blood pressure control. Spontaneously hypertensive rats (SHR)…”
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Increased expression of acyl-CoA oxidase 2 in the kidney with plasma phytanic acid and altered gut microbiota in spontaneously hypertensive rats by Okamura, Masahiro, Ueno, Takahiro, Tanaka, Sho, Murata, Yusuke, Kobayashi, Hiroki, Miyamoto, Aoi, Abe, Masanori, Fukuda, Noboru

“…We performed a DNA microarray analysis of the renal medulla and cortex from spontaneously hypertensive rats (SHRs), stroke-prone SHRs (SHRSPs), and…”
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Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential by Matsumoto, Taro, Kano, Koichiro, Kondo, Daisuke, Fukuda, Noboru, Iribe, Yuji, Tanaka, Nobuaki, Matsubara, Yoshiyuki, Sakuma, Takahiro, Satomi, Aya, Otaki, Munenori, Ryu, Jyunnosuke, Mugishima, Hideo

“…When mature adipocytes are subjected to an in vitro dedifferentiation strategy referred to as ceiling culture, these mature adipocytes can revert to a more…”
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Scoring system for the diagnosis of bilateral primary aldosteronism in the outpatient setting before adrenal venous sampling by Kobayashi, Hiroki, Haketa, Akira, Ueno, Takahiro, Ikeda, Yukihiro, Hatanaka, Yoshinari, Tanaka, Sho, Otsuka, Hiromasa, Abe, Masanori, Fukuda, Noboru, Soma, Masayoshi

“…Summary Objective The only reliable method for subtyping primary aldosteronism (PA) is adrenal venous sampling (AVS), which is costly and time‐consuming…”
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Urethral injection of dedifferentiated fat cells ameliorates sphincter damage and voiding dysfunction in a rat model of persistence stress urinary incontinence by Murata, Yasutaka, Obinata, Daisuke, Matsumoto, Taro, Ikado, Yuichiro, Kano, Koichiro, Fukuda, Noboru, Yamaguchi, Kenya, Takahashi, Satoru

“…Purpose Dedifferentiated fat (DFAT) cells are mature adipocyte-derived multipotent cells that can be applicable to cell-based therapy for stress urinary…”
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Gut-Microbiota Dysbiosis in Stroke-Prone Spontaneously Hypertensive Rats with Diet-Induced Steatohepatitis by Kanezawa, Shini, Moriyama, Mitsuhiko, Kanda, Tatsuo, Fukushima, Akiko, Masuzaki, Ryota, Sasaki-Tanaka, Reina, Tsunemi, Akiko, Ueno, Takahiro, Fukuda, Noboru, Kogure, Hirofumi

“…Metabolic-dysfunction-associated fatty-liver disease (MAFLD) is the principal worldwide cause of liver disease. Individuals with nonalcoholic steatohepatitis…”
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Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice by Kitai, Maki, Fukuda, Noboru, Ueno, Takahiro, Endo, Morito, Maruyama, Takashi, Abe, Masanori, Okada, Kazuyoshi, Soma, Masayoshi, Matsumoto, Koichi

“…The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on…”
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Tumor-selective mitochondrial network collapse induced by atmospheric gas plasma-activated medium by Saito, Kosuke, Asai, Tomohiko, Fujiwara, Kyoko, Sahara, Junki, Koguchi, Haruhisa, Fukuda, Noboru, Suzuki-Karasaki, Miki, Soma, Masayoshi, Suzuki-Karasaki, Yoshihiro

“…Non-thermal atmospheric gas plasma (AGP) exhibits cytotoxicity against malignant cells with minimal cytotoxicity toward normal cells. However, the mechanisms…”
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Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice by Zhou, Xueli, Fukuda, Noboru, Matsuda, Hiroyuki, Endo, Morito, Wang, Xiaofei, Saito, Kosuke, Ueno, Takahiro, Matsumoto, Taro, Matsumoto, Koichi, Soma, Masayoshi, Kobayashi, Naohiko, Nishiyama, Akira

“…We have demonstrated that mesenchymal cells from spontaneously hypertensive rats genetically express complement 3 (C3). Mature tubular epithelial cells can…”
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Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter by Okamura, Makiyo, Fukuda, Noboru, Horikoshi, Shu, Kobayashi, Hiroki, Tsunemi, Akiko, Akiya, Yurie, Endo, Morito, Matsumoto, Taro, Abe, Masanori

“…Upstream stimulatory factor 1 (USF1) is a transcription factor that is increased in high-glucose conditions and activates the transforming growth factor…”
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Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells by Takagi, Keiko, Midorikawa, Yutaka, Takayama, Tadatoshi, Abe, Hayato, Fujiwara, Kyoko, Soma, Masayoshi, Nagase, Hiroki, Miki, Toshio, Fukuda, Noboru

“…Synthetic pyrrole-imidazole (PI) polyamides bind to the minor groove of double-helical DNA with high affinity and specificity, and inhibit the transcription of…”
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Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset by Otsuki, Masari, Fukuda, Noboru, Inoue, Takashi, Mineshige, Takayuki, Otsuki, Tomoyasu, Horikoshi, Shu, Endo, Morito, Abe, Masanori

“…Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene…”
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Implantation of dedifferentiated fat cells ameliorated antineutrophil cytoplasmic antibody glomerulonephritis by immunosuppression and increases in tumor necrosis factor-stimulated gene-6 by Utsunomiya, Kei, Maruyama, Takashi, Shimizu, Satoshi, Matsumoto, Taro, Endo, Morito, Kobayashi, Hiroki, Kano, Koichiro, Abe, Masanori, Fukuda, Noboru

“…Abstract Introduction The implantation of dedifferentiated fat (DFAT) cells has been shown to exert immunosuppressive effects. To develop DFAT cell therapy for…”
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