Search Results - "FUJIYAMA, Shigetoshi"

Hepatitis B virus reactivation associated with antirheumatic therapy: risk and prophylaxis recommendations by Mori, Shunsuke, Fujiyama, Shigetoshi

“…Accompanying the increased use of biological and non-biological antirheumatic drugs,a greater number of cases of hepatitis B virus(HBV) reactivation have been…”
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Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment by Mori, Shunsuke, Arima, Nobuyuki, Ito, Masahiro, Fujiyama, Shigetoshi, Kamo, Yasuhiro, Ueki, Yukitaka

“…The mechanism of liver injury with low-dose methotrexate (MTX) is incompletely understood. This study was designed to evaluate the association between…”
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Systemic Lupus Erythematosus-associated Acute Acalculous Cholecystitis Successfully Treated by a Corticosteroid Combined with Azathioprine by Kudo, Noritaka, Takaoka, Hirokazu, Shimomura, Taizo, Suzushima, Hitoshi, Fujiyama, Shigetoshi

“…A 69-year-old Japanese woman was transferred to our hospital due to pancytopenia with a fever. She had Murphy's sign, and computed tomography showed pleural…”
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Sofosbuvir–velpatasvir in adults with hepatitis C virus infection and compensated cirrhosis in Japan by Takehara, Tetsuo, Izumi, Namiki, Mochida, Satoshi, Genda, Takuya, Fujiyama, Shigetoshi, Notsumata, Kazuo, Tamori, Akihiro, Suzuki, Fumitaka, Suri, Vithika, Mercier, Renee‐Claude, Matsuda, Takuma, Matsuda, Kana, Kato, Naoya, Chayama, Kazuaki, Kumada, Hiromitsu

“…Background & Purpose Protease‐free regimens for chronic hepatitis C virus (HCV) infection are safe and effective for persons with either compensated or…”
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Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection by Toyota, Joji, Karino, Yoshiyasu, Suzuki, Fumitaka, Ikeda, Fusao, Ido, Akio, Tanaka, Katsuaki, Takaguchi, Koichi, Naganuma, Atsushi, Tomita, Eiichi, Chayama, Kazuaki, Fujiyama, Shigetoshi, Inada, Yukiko, Yoshiji, Hitoshi, Watanabe, Hideaki, Ishikawa, Hiroki, Hu, Wenhua, McPhee, Fiona, Linaberry, Misti, Yin, Philip D., Swenson, Eugene Scott, Kumada, Hiromitsu

“…Background DCV-TRIO, a fixed-dose combination of daclatasvir (pangenotypic NS5A inhibitor), asunaprevir (NS3/4A protease inhibitor), and beclabuvir…”
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Randomized comparison of daclatasvir + asunaprevir versus telaprevir + peginterferon/ribavirin in Japanese hepatitis C virus patients by Kumada, Hiromitsu, Suzuki, Fumitaka, Suzuki, Yoshiyuki, Toyota, Joji, Karino, Yoshiyasu, Chayama, Kazuaki, Kawakami, Yoshiiku, Fujiyama, Shigetoshi, Ito, Takayoshi, Itoh, Yoshito, Tamura, Etsuko, Ueki, Tomoko, Ishikawa, Hiroki, Hu, Wenhua, McPhee, Fiona, Linaberry, Misti, Hughes, Eric

“…Background and Aim Daclatasvir combined with asunaprevir is the first all‐oral, ribavirin‐free treatment of hepatitis C virus genotype 1b infection in Japan…”
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Usefulness of virtual touch quantification for staging liver fibrosis in patients with hepatitis C, and factors affecting liver stiffness measurement failure compared with liver biopsy by Tsukano, Natsumi, Miyase, Shiho, Saeki, Tatsuhiko, Mizobe, Keiko, Iwashita, Hirofumi, Arima, Nobuyuki, Fujiyama, Shigetoshi

“…Aim The assessment of liver fibrosis in patients with hepatitis C is important to predict carcinogenesis. In this study, we evaluated the usefulness of virtual…”
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Incidence, predictive factors and severity of methotrexate-related liver injury in rheumatoid arthritis: a longitudinal cohort study by Mori, Shunsuke, Arima, Nobuyuki, Ito, Masahiro, Ueki, Yukitaka, Abe, Yasuyo, Aoyagi, Kiyoshi, Fujiyama, Shigetoshi

“…Abstract Objectives The aims were to determine the incidence rate, predictive factors and severity of liver injury that develops during MTX treatment for RA…”
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Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: A randomized phase III trial by Okusaka, Takuji, Kasugai, Hiroshi, Shioyama, Yasukazu, Tanaka, Katsuaki, Kudo, Masatoshi, Saisho, Hiromitsu, Osaki, Yukio, Sata, Michio, Fujiyama, Shigetoshi, Kumada, Takashi, Sato, Keiko, Yamamoto, Seiichiro, Hinotsu, Shiro, Sato, Tosiya

“…Background/Aims Transcatheter arterial chemoembolization (TACE) is a combination of transarterial infusion chemotherapy (TAI) and embolization, and has been…”
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Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker by Nakatsura, Tetsuya, Yoshitake, Yoshihiro, Senju, Satoru, Monji, Mikio, Komori, Hiroyuki, Motomura, Yutaka, Hosaka, Seiji, Beppu, Toru, Ishiko, Takatoshi, Kamohara, Hidenobu, Ashihara, Hiroshi, Katagiri, Toyomasa, Furukawa, Yoichi, Fujiyama, Shigetoshi, Ogawa, Michio, Nakamura, Yusuke, Nishimura, Yasuharu

“…With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing world wide. We identified…”
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Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study by Suzuki, Fumitaka, Suzuki, Yoshiyuki, Karino, Yoshiyasu, Tanaka, Yasuhito, Kurosaki, Masayuki, Yatsuhashi, Hiroshi, Atarashi, Tomofumi, Atsukawa, Masanori, Watanabe, Tsunamasa, Enomoto, Masaru, Kudo, Masatoshi, Maeda, Naoto, Kohno, Hiroshi, Joko, Kouji, Michitaka, Kojiro, Miki, Koichiro, Takahashi, Kazuhiro, Ide, Tatsuya, Fujiyama, Shigetoshi, Kohno, Tomoko, Itoh, Hiroshi, Tsukamoto, Sakiyo, Suzuki, Yuko, Kawano, Yoshiaki, Sugiura, Wataru, Kumada, Hiromitsu

“…Tenofovir disoproxil fumarate (TDF) is widely used and recommended as first-line treatment for patients infected with the hepatitis B virus (HBV). However,…”
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Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study by Kawaguchi, Takumi, Komori, Atsumasa, Seike, Masataka, Fujiyama, Shigetoshi, Watanabe, Hiroshi, Tanaka, Masatoshi, Sakisaka, Shotaro, Nakamuta, Makoto, Sasaki, Yutaka, Oketani, Makoto, Hattori, Toshihiro, Katsura, Koichi, Sata, Michio

“…Background Eltrombopag is an oral thrombopoietin receptor agonist that stimulates thrombopoiesis and shows higher exposure in East Asian patients than in…”
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Randomized trial of peginterferon α-2a plus ribavirin versus peginterferon α-2b plus ribavirin for chronic hepatitis C in Japanese patients by Miyase, Shiho, Haraoka, Katsuki, Ouchida, Yoshihiro, Morishita, Yuko, Fujiyama, Shigetoshi

“…Background Pegylated interferon (PegIFN) plus ribavirin is the standard therapy for patients with chronic hepatitis C genotype 1. Although several randomized…”
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Risk factors for development of hepatocellular carcinoma in patients with chronic hepatitis C after sustained response to interferon by Ikeda, Masafumi, Fujiyama, Shigetoshi, Tanaka, Motohiko, Sata, Michio, Ide, Tatsuya, Yatsuhashi, Hiroshi, Watanabe, Hiroshi

“…Interferon (IFN) is expected to prevent the progression of hepatitis C virus infection to cirrhosis and the development of hepatocellular carcinoma (HCC), but…”
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection by Akuta, Norio, Toyota, Joji, Karino, Yoshiyasu, Ikeda, Fusao, Ido, Akio, Tanaka, Katsuaki, Takaguchi, Koichi, Naganuma, Atsushi, Tomita, Eiichi, Chayama, Kazuaki, Fujiyama, Shigetoshi, Inada, Yukiko, Yoshiji, Hitoshi, Watanabe, Hideaki, Ishikawa, Hiroki, McPhee, Fiona, Noviello, Stephanie, Kumada, Hiromitsu

“…Background In the UNITY-3 study, 96% sustained virologic response (SVR12) rate was observed in Japanese patients with hepatitis C virus (HCV) genotype (GT)-1…”
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Interferon therapy prolonged life expectancy among chronic hepatitis C patients by Yoshida, Haruhiko, Arakawa, Yasuyuki, Sata, Michio, Nishiguchi, Shuhei, Yano, Michitami, Fujiyama, Shigetoshi, Yamada, Gotarou, Yokosuka, Osamu, Shiratori, Yasushi, Omata, Masao

“…Background & Aims: The effects of interferon therapy in chronic hepatitis C patients on survival are unclear. Our objective was to analyze survival among a…”
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Open-labeled randomized controlled trial to compare diuretic therapy with recombinant human serum albumin and diuretic therapy for therapeutic treatment of ascites in patients with advanced liver cirrhosis: An exploratory trial by Nakamura, Toru, Sata, Michio, Suzuki, Kazuyuki, Moriwaki, Hisataka, Fukui, Hiroshi, Fujiyama, Shigetoshi, Imawari, Michio

“…Aim There have been only a few trials demonstrating additional effects of human serum albumin (HSA) on diuretic therapy in patients with cirrhotic ascites. We…”
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Randomized, double‐blind, placebo‐controlled trial of bovine lactoferrin in patients with chronic hepatitis C by Ueno, Hideki, Sato, Tosiya, Yamamoto, Seiichiro, Tanaka, Katsuaki, Ohkawa, Shinichi, Takagi, Hitoshi, Yokosuka, Osamu, Furuse, Junji, Saito, Hidetsugu, Sawaki, Akira, Kasugai, Hiroshi, Osaki, Yukio, Fujiyama, Shigetoshi, Sato, Keiko, Wakabayashi, Keiji, Okusaka, Takuji

“…Several studies have suggested that lactoferrin administration may decrease the serum level of hepatitis C virus (HCV) RNA in patients with chronic hepatitis…”
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An open-label phase I/II study of tamibarotene in patients with advanced hepatocellular carcinoma by Kanai, Fumihiko, Obi, Shuntaro, Fujiyama, Shigetoshi, Shiina, Shuichiro, Tamai, Hideyuki, Mochizuki, Hitoshi, Koike, Yukihiro, Imamura, Jun, Yamaguchi, Takayoshi, Saida, Isamu, Yokosuka, Osamu, Omata, Masao

“…Aim Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid…”
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Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell- cell contacts by ITO, K, OKAMOTO, I, ARAKI, N, KAWANO, Y, NAKAO, M, FUJIYAMA, S, TOMITA, K, MIMORI, T, SAYA, H

“…Cadherins are major cell-cell adhesion molecules in both tumor and normal tissues. Although serum levels of soluble E-cadherin have been shown to be higher in…”
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