Search Results - "FUJIWARA, Yasuhiro"

Evolution of frameworks for expediting access to new drugs in Japan by Fujiwara, Yasuhiro

“…Japanese clinical research and regulatory frameworks have evolved considerably in the past two decades to reduce the delay in the introduction of new drugs in…”
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Symptom-based diagnostic approach for eosinophilic esophagitis by Fujiwara, Yasuhiro

“…The prevalence of eosinophilic esophagitis (EoE) has been increasing in Japan. Although the diagnosis of EoE is based on simple criteria that include the…”
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Epidemiology and clinical characteristics of GERD in the Japanese population by Fujiwara, Yasuhiro, Arakawa, Tetsuo

“…We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in…”
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Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review by Watanabe, Toshio, Fujiwara, Yasuhiro, Chan, Francis K. L.

“…Recent advances in small-bowel endoscopy such as capsule endoscopy have shown that non-steroidal anti-inflammatory drugs (NSAIDs) frequently damage the small…”
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A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination by Zhang, Jingjing, Fujiwara, Yasuhiro, Yamamoto, Shohei, Shibuya, Hiroki

“…Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) to maintain genomic integrity. Recombinase recruited to the DSBs by the mediator protein…”
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Up-to-date treatment of GERD by Fujiwara, Yasuhiro

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Novel combination of serum microRNA for detecting breast cancer in the early stage by Shimomura, Akihiko, Shiino, Sho, Kawauchi, Junpei, Takizawa, Satoko, Sakamoto, Hiromi, Matsuzaki, Juntaro, Ono, Makiko, Takeshita, Fumitaka, Niida, Shumpei, Shimizu, Chikako, Fujiwara, Yasuhiro, Kinoshita, Takayuki, Tamura, Kenji, Ochiya, Takahiro

“…MicroRNA (miRNA), which are stably present in serum, have been reported to be potentially useful for detecting cancer. In the present study, we examined the…”
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Real world treatment patterns in patients with eosinophilic esophagitis in Japan by Sawada, Akinari, Ihara, Yasutaka, Imai, Takumi, Tanaka, Fumio, Fujiwara, Yasuhiro

“…The management of eosinophilic esophagitis (EoE) has not been completely established yet. There is a controversy over the universal maintenance therapy for EoE…”
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Reply to the letter by Ouyang et al. regarding our manuscript “Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer” by Watanabe, Toshio, Nadatani, Yuji, Fujiwara, Yasuhiro

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Esophageal Reflux Hypersensitivity: A Comprehensive Review by Sawada, Akinari, Sifrim, Daniel, Fujiwara, Yasuhiro

“…Reflux hypersensitivity (RH) is one of the phenotypes of gastroesophageal reflux disease. The latest Rome IV defines RH as a condition with typical reflux…”
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Efficacy of Upadacitinib As a Second-line JAK Inhibitor in Ulcerative Colitis: A Case Series by Hosomi, Shuhei, Nishida, Yu, Fujiwara, Yasuhiro

“…Upadacitinib, a recently approved Janus kinase (JAK) inhibitor specific for JAK1, may be a promising candidate in patients with ulcerative colitis (UC) who…”
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Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: A hospital‐based study by Sunami, Kuniko, Ichikawa, Hitoshi, Kubo, Takashi, Kato, Mamoru, Fujiwara, Yutaka, Shimomura, Akihiko, Koyama, Takafumi, Kakishima, Hiroki, Kitami, Mayuko, Matsushita, Hiromichi, Furukawa, Eisaku, Narushima, Daichi, Nagai, Momoko, Taniguchi, Hirokazu, Motoi, Noriko, Sekine, Shigeki, Maeshima, Akiko, Mori, Taisuke, Watanabe, Reiko, Yoshida, Masayuki, Yoshida, Akihiko, Yoshida, Hiroshi, Satomi, Kaishi, Sukeda, Aoi, Hashimoto, Taiki, Shimizu, Toshio, Iwasa, Satoru, Yonemori, Kan, Kato, Ken, Morizane, Chigusa, Ogawa, Chitose, Tanabe, Noriko, Sugano, Kokichi, Hiraoka, Nobuyoshi, Tamura, Kenji, Yoshida, Teruhiko, Fujiwara, Yasuhiro, Ochiai, Atsushi, Yamamoto, Noboru, Kohno, Takashi

“…Next‐generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide clinical management by providing information about actionable gene…”
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Using gel immersion endoscopy to control duodenum spasm during endoscopic retrograde cholangiopancreatography by Ishikawa-Kakiya, Yuki, Maruyama, Hirotsugu, Tanoue, Kojiro, Higashimori, Akira, Fukunaga, Shusei, Fujiwara, Yasuhiro

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Improvement in the contrast-to-noise ratio and quantitative measurement of T1 and T2 values for carotid atherosclerotic plaque using multi-echo phase-sensitive inversion recovery by Fujiwara, Yasuhiro, Mio, Motohira

“…Quantitative magnetic resonance imaging is required to accurately evaluate carotid plaque vulnerability. We prospectively evaluated the potential for fast…”
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Gastroesophageal reflux disease and sleep disturbances by Fujiwara, Yasuhiro, Arakawa, Tetsuo, Fass, Ronnie

“…Nighttime reflux during sleep plays a crucial role in several conditions associated with gastroesophageal reflux disease (GERD). Reflux patterns during arousal…”
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The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells by Zhang, Jingjing, Gurusaran, Manickam, Fujiwara, Yasuhiro, Zhang, Kexin, Echbarthi, Meriem, Vorontsov, Egor, Guo, Rui, Pendlebury, Devon F., Alam, Intekhab, Livera, Gabriel, Emmanuelle, Martini, Wang, P. Jeremy, Nandakumar, Jayakrishnan, Davies, Owen R., Shibuya, Hiroki

“…Breast cancer susceptibility gene II ( BRCA2 ) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand…”
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Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer by Watanabe, Toshio, Nadatani, Yuji, Suda, Wataru, Higashimori, Akira, Otani, Koji, Fukunaga, Shusei, Hosomi, Shuhei, Tanaka, Fumio, Nagami, Yasuaki, Taira, Koichi, Tanigawa, Tetsuya, Nakatsu, Geicho, Hattori, Masahira, Fujiwara, Yasuhiro

“…Background Gastric microbiome, other than Helicobacter pylori , plays a role in the tumorigenesis of gastric cancer (GC). Patients who undergo endoscopic…”
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Genomics, Health Care, and Society by Fujiwara, Yasuhiro

“…To the Editor: Hudson, in her otherwise comprehensive review article on genomic medicine (Sept. 15 issue), 1 did not mention the issue of reimbursement and the…”
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Have We Found the Key to Unravel Treatment Development Lags for Rare Cancers?: MASTER KEY Project by Okuma, Hitomi S., Fujiwara, Yasuhiro

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A multi-national, randomised, open-label, parallel, phase III non-inferiority study comparing NK105 and paclitaxel in metastatic or recurrent breast cancer patients by Fujiwara, Yasuhiro, Mukai, Hirofumi, Saeki, Toshiaki, Ro, Jungsil, Lin, Yung-Chang, Nagai, Shigenori E., Lee, Keun Seok, Watanabe, Junichiro, Ohtani, Shoichiro, Kim, Sung Bae, Kuroi, Katsumasa, Tsugawa, Koichiro, Tokuda, Yutaka, Iwata, Hiroji, Park, Yeon Hee, Yang, Youngsen, Nambu, Yoshihiro

“…Background NK105 is a novel nanoparticle drug delivery formulation that encapsulates paclitaxel (PTX) in polymeric micelles. We conducted an open-label phase…”
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