Search Results - "FUJIWARA, YUKIO"

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy by Komohara, Yoshihiro, Fujiwara, Yukio, Ohnishi, Koji, Takeya, Motohiro

“…The macrophage is known to be a multifunctional antigen presenting cells and playing a central role in inflammation. Macrophages infiltrate into malignant…”
Get full text

Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma by Komohara, Yoshihiro, Hasita, Horlad, Ohnishi, Koji, Fujiwara, Yukio, Suzu, Shinya, Eto, Masatoshi, Takeya, Motohiro

“…Most malignant tumors evidence infiltration of many macrophages. In this study, we investigated an anti‐inflammatory macrophage phenotype (M2) in clear cell…”
Get full text

Negative ion beam bombardment of a protic ionic liquid: Alleviating surface charging and damage and analyzing the surface of organic insulating materials by Fujiwara, Yukio, Saito, Naoaki

“…Positive ion beams are widely used in surface processing and analysis; however, serious surface charging can occur in the case of insulating materials. To…”
Get full text

Negative-cluster ion beam production from the tip of a sharp needle: Suppression of surface charging and surface analysis of an insulated sample by Fujiwara, Yukio, Saito, Naoaki

“…In focused ion beam technology, liquid metal ion sources (LMISs) are widely used; however, they cannot produce negative ion beams. In this work, we demonstrate…”
Get full text

Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes by Komohara, Yoshihiro, Kurotaki, Daisuke, Tsukamoto, Hirotake, Miyasato, Yuko, Yano, Hiromu, Pan, Cheng, Yamamoto, Yutaka, Fujiwara, Yukio

“…Tumor‐associated macrophages (TAMs) are the most prominent immune cells in the breast cancer microenvironment, and the protumor functions of TAMs are thought…”
Get full text

Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription‐3 and nuclear factor‐kappa B in tumor cells and tumor‐associated macrophages by Fujiwara, Yukio, Komohara, Yoshihiro, Ikeda, Tsuyoshi, Takeya, Motohiro

“…Tumor‐associated macrophages (TAM) of M2 phenotype promote tumor proliferation and are associated with a poor prognosis in patients with glioblastoma. We…”
Get full text

CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma by Shiraishi, Daisuke, Fujiwara, Yukio, Horlad, Hasita, Saito, Yoichi, Iriki, Toyohisa, Tsuboki, Junko, Cheng, Pan, Nakagata, Naomi, Mizuta, Hiroshi, Bekki, Hirofumi, Nakashima, Yasuharu, Oda, Yoshinao, Takeya, Motohiro, Komohara, Yoshihiro

“…Recent findings have shown the significance of CD163-positive macrophages in tumor progression, yet there have been few studies on the function of CD163 in…”
Get full text

An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (PD‐L1/2) on infiltrating macrophages in lymphoma by Horlad, Hasita, Ma, Chaoya, Yano, Hiromu, Pan, Cheng, Ohnishi, Koji, Fujiwara, Yukio, Endo, Shinya, Kikukawa, Yoshitaka, Okuno, Yutaka, Matsuoka, Masao, Takeya, Motohiro, Komohara, Yoshihiro

“…Immune escape and tolerance in the tumor microenvironment are closely involved in tumor progression, and are caused by T‐cell exhaustion and mediated by the…”
Get full text

Cluster ion beam generation from a wetted needle emitter for organic secondary ion mass spectrometry (organic SIMS) using a protic ionic liquid, propylammonium nitrate by Fujiwara, Yukio, Saito, Naoaki

“…Rationale Propylammonium nitrate (PAN, [C3H7NH3][NO3]), a protic ionic liquid, has an active proton in its molecular structure, so that it can promote…”
Get full text

Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages by Tanaka, Ryusuke, Saito, Yoichi, Fujiwara, Yukio, Jo, Jun-ichiro, Tabata, Yasuhiko

“…[Display omitted] Macrophages play an important role in regulating inflammation and tissue regeneration. In the present study, uniform fibrin hydrogel…”
Get full text

Contribution of Macrophage Polarization to Metabolic Diseases by Komohara, Yoshihiro, Fujiwara, Yukio, Ohnishi, Koji, Shiraishi, Daisuke, Takeya, Motohiro

“…Macrophage activation is one of the major immunological events in the pathogenesis of various diseases. Recent studies have disclosed that complicated…”
Get full text

Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy by Yano, Hiromu, Fujiwara, Yukio, Horlad, Hasita, Pan, Chang, Kai, Keitaro, Niino, Daisuke, Ohsawa, Kumiko, Higashi, Morihiro, Nosaka, Kisato, Okuno, Yutaka, Tamaru, Jun‐ichi, Mukasa, Akitake, Matsuoka, Masao, Komohara, Yoshihiro

“…Cholesterol is an essential plasma membrane lipid for the maintenance of cellular homeostasis and cancer cell proliferation. Free cholesterol is harmful to…”
Get full text

Time‐of‐flight secondary ion mass spectrometry using a new primary ion beam generated by vacuum electrospray of a protic ionic liquid, propylammonium nitrate by Fujiwara, Yukio, Saito, Naoaki

“…Rationale Protic ionic liquids have the potential to be useful materials for primary ion beams in terms of protonation, since they have active protons…”
Get full text

Thiolane-type sulfides from garlic, onion, and Welsh onion by Nohara, Toshihiro, Fujiwara, Yukio, El-Aasr, Mona, Ikeda, Tsuyoshi, Ono, Masateru, Nakano, Daisuke, Kinjo, Junei

“…In this paper, we review our work in the last 10 years wherein we examined the sulfides in the acetone extracts of garlic ( Allium sativum ), onion ( A. cepa…”
Get full text

Intracellular Accumulation of Advanced Glycation End Products Induces Osteoblast Apoptosis Via Endoplasmic Reticulum Stress by Suzuki, Ryusuke, Fujiwara, Yukio, Saito, Mitsuru, Arakawa, Shoutaro, Shirakawa, Jun‐ichi, Yamanaka, Mikihiro, Komohara, Yoshihiro, Marumo, Keishi, Nagai, Ryoji

“…ABSTRACT Osteoporosis is an aging‐associated disease that is attributed to excessive osteoblast apoptosis. It is known that the accumulation of advanced…”
Get full text

Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress by Maeshiro, Manabu, Shinriki, Satoru, Liu, Rin, Nakachi, Yutaka, Komohara, Yoshihiro, Fujiwara, Yukio, Ohtsubo, Kazuaki, Yoshida, Ryoji, Iwamoto, Kazuya, Nakayama, Hideki, Matsui, Hirotaka

“…Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition…”
Get full text

Accurate expression of PD‐L1/L2 in lung adenocarcinoma cells: A retrospective study by double immunohistochemistry by Shinchi, Yusuke, Komohara, Yoshihiro, Yonemitsu, Kimihiro, Sato, Kensaku, Ohnishi, Koji, Saito, Yoichi, Fujiwara, Yukio, Mori, Takeshi, Shiraishi, Kenji, Ikeda, Koei, Suzuki, Makoto

“…The percentage of programmed death ligand 1 (PD‐L1) positivity in cancer cells, named as the tumor proportion score, is considered to be a predictive biomarker…”
Get full text

Micro-abrasive glass surface for producing microplastics for biological tests by Nakanishi, Yoshitaka, Yamaguchi, Hajime, Hirata, Yusuke, Nakashima, Yuta, Fujiwara, Yukio

“…The ubiquitous presence of microplastics in the environment has raised serious concern, and several studies have been carried out in this regard. This study…”
Get full text

Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma by Yano, Hiromu, Fujiwara, Yukio, Komohara, Yoshihiro

“…Cholesterol uptake via LDL receptor (LDLR) is increased in some malignant tumors, and incorporated LDL contribute to lipid droplet formation. Burkitt’s…”
Get full text

Microchamber device for studying phagocytosis of ultra-high molecular weight polyethylene particles by human monocyte-derived macrophages by Nakanishi, Yoshitaka, Fujiwara, Yukio, Nakashima, Yuta, Komohara, Yoshihiro, Hino, Kazunori, Miura, Hiromasa, Higaki, Hidehiko

“…It is well established in the literature that polyethylene wear particles are involved in loosening of joint prostheses. To investigate the phagocytosis of…”
Get full text