Search Results - "FUJIWARA, HIROAKI"

Association of glucagon‐like peptide‐1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy by Kobori, Toshiko, Onishi, Yukiko, Yoshida, Yoko, Tahara, Tazu, Kikuchi, Takako, Kubota, Tetsuya, Iwamoto, Masahiko, Sawada, Tomonobu, Kobayashi, Reo, Fujiwara, Hiroaki, Kasuga, Masato

“…Aims/Introduction Previous studies have reported that the glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) delays gastric emptying, and gastric emptying was…”
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NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice by Maeda, Shin, Hikiba, Yohko, Fujiwara, Hiroaki, Ikenoue, Tsuneo, Sue, Soichiro, Sugimori, Makoto, Matsubayashi, Mao, Kaneko, Hiroaki, Irie, Kuniyasu, Sasaki, Tomohiko, Chuma, Makoto

“…Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition, affecting up to 25% of the population worldwide. NAFLD has been linked to several…”
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Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment by Sano, Makoto, Ijichi, Hideaki, Takahashi, Ryota, Miyabayashi, Koji, Fujiwara, Hiroaki, Yamada, Tomoharu, Kato, Hiroyuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Keisuke, Morishita, Yasuyuki, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction (desmoplasia). We have previously reported that mice with conditional Kras…”
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Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer by Takahashi, Ryota, Ijichi, Hideaki, Sano, Makoto, Miyabayashi, Koji, Mohri, Dai, Kim, Jinsuk, Kimura, Gen, Nakatsuka, Takuma, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Tanaka, Yasuo, Tateishi, Keisuke, Nakai, Yousuke, Morishita, Yasuyuki, Soma, Katsura, Takeda, Norihiko, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko

“…Pancreatic cancer is one of the malignant diseases with the worst prognosis. Resistance to chemotherapy is a major difficulty in treating the disease. We…”
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HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers by Kato, Hiroyuki, Tateishi, Keisuke, Iwadate, Dosuke, Yamamoto, Keisuke, Fujiwara, Hiroaki, Nakatsuka, Takuma, Kudo, Yotaro, Hayakawa, Yoku, Ijichi, Hideaki, Otsuka, Motoyuki, Kishikawa, Takahiro, Takahashi, Ryota, Miyabayashi, Koji, Nakai, Yousuke, Hirata, Yoshihiro, Toyoda, Atsushi, Morishita, Shinichi, Fujishiro, Mitsuhiro

“…The molecular subtypes of pancreatic cancer (PC), either classical/progenitor‐like or basal/squamous‐like, are currently a major topic of research because of…”
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Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis by Nakatsuka, Takuma, Tateishi, Keisuke, Kato, Hiroyuki, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Ikenoue, Tsuneo, Ishizawa, Takeaki, Hasegawa, Kiyoshi, Tachibana, Makoto, Shinkai, Yoichi, Koike, Kazuhiko

“…While the significance of acquired genetic abnormalities in the initiation of hepatocellular carcinoma (HCC) has been established, the role of epigenetic…”
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Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1 by Fujiwara, Hiroaki, Tateishi, Keisuke, Kato, Hiroyuki, Nakatsuka, Takuma, Yamamoto, Keisuke, Tanaka, Yasuo, Ijichi, Hideaki, Takahara, Naminatsu, Mizuno, Suguru, Kogure, Hirofumi, Matsubara, Saburo, Nakai, Yousuke, Koike, Kazuhiko

“…Cholangiocarcinoma is a life‐threatening disease with a poor prognosis. Although genome analysis unraveled some genetic mutation profiles in…”
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Total Synthesis of (−)-Isoschizogamine by Takada, Akihiro, Fujiwara, Hiroaki, Sugimoto, Kenji, Ueda, Hirofumi, Tokuyama, Hidetoshi

“…The total synthesis of (−)‐isoschizogamine was accomplished, featuring the construction of the quaternary carbon center by the modified Johnson–Claisen…”
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Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer by Yamamoto, Keisuke, Tateishi, Keisuke, Kudo, Yotaro, Hoshikawa, Mayumi, Tanaka, Mariko, Nakatsuka, Takuma, Fujiwara, Hiroaki, Miyabayashi, Koji, Takahashi, Ryota, Tanaka, Yasuo, Ijichi, Hideaki, Nakai, Yousuke, Isayama, Hiroyuki, Morishita, Yasuyuki, Aoki, Taku, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Fukayama, Masashi, Koike, Kazuhiko

“…Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family of chromatin reader proteins, have therapeutic efficacy against various…”
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Association of insulin treatment with gastric residue during an esophagogastroduodenoscopy by Kobori, Toshiko, Onishi, Yukiko, Iwamoto, Masahiko, Kubota, Tetsuya, Kikuchi, Takako, Tahara, Tazu, Takao, Toshiko, Fujiwara, Hiroaki, Yoshida, Yoko, Kasuga, Masato

“…The purpose of this study was to investigate the association of glycemic control and diabetes treatment to gastric residue observed during an…”
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Probe-guided endoscopic system for 5-aminolevulinic acid-based photodynamic diagnosis in cholangiocarcinoma by Fujiwara, Hiroaki, Furudate, Shiho, Takahara, Naminatsu, Nakai, Yousuke, Kodama, Yuki, Arai, Junya, Nakagawa, Hayato, Ikenoue, Tsuneo, Tateishi, Keisuke, Kasuga, Masato, Fujishiro, Mitsuhiro

“…•5-ALA-PDD for Pp IX fluorescence imaging of cholangiocarcinoma in the biliary tract.•Small-diameter flexible camera and light guide developed for per-oral…”
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Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation by Fujiwara, Hiroaki, Tateishi, Keisuke, Misumi, Kento, Hayashi, Akimasa, Igarashi, Kaori, Kato, Hiroyuki, Nakatsuka, Takuma, Suzuki, Nobumi, Yamamoto, Keisuke, Kudo, Yotaro, Hayakawa, Yoku, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Kogure, Hirofumi, Nakai, Yosuke, Isayama, Hiroyuki, Hasegawa, Kiyoshi, Fukayama, Masashi, Soga, Tomoyoshi, Koike, Kazuhiko

“…Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during…”
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Magnetothermal force effect on natural convection through a partially-heated vertical channel by Kengo WADA, Hiroaki FUJIWARA, Masayuki KANEDA, Kazuhiko SUGA

“…Natural convection of a paramagnetic fluid through a partially-heated vertical channel is numerically studied in the presence of a magnetic field from two…”
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5-Aminolevulinic acid-mediated photodynamic activity in patient-derived cholangiocarcinoma organoids by Fujiwara, Hiroaki, Takahara, Naminatsu, Tateishi, Keisuke, Tanaka, Mariko, Kanai, Sachiko, Kato, Hiroyuki, Nakatsuka, Takuma, Yamamoto, Keisuke, Kogure, Hirofumi, Arita, Junichi, Nakai, Yousuke, Kasuga, Masato, Ushiku, Tetsuo, Hasegawa, Kiyoshi, Koike, Kazuhiko

“…Accurate diagnosis of the disease extension of cholangiocarcinoma (CCA) is often difficult in clinical practice. The diagnostic yield of conventional…”
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Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients by Arai, Junya, Fujiwara, Hiroaki, Aoki, Tomonori, Niikura, Ryota, Ihara, Sozaburo, Suzuki, Nobumi, Hayakawa, Yoku, Kasuga, Masato, Fujishiro, Mitsuhiro

“…Background: Previous studies demonstrate an association between metabolic factors and Helicobacter pylori-related gastric cancer. However, the association of…”
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Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblasts by KIYOSHIMA, TAMOTSU, ENOKI, NORIO, KOBAYASHI, IEYOSHI, SAKAI, TAKAKO, NAGATA, KENGO, WADA, HIROKO, FUJIWARA, HIROAKI, OOKUMA, YUKIKO, SAKAI, HIDETAKA

“…Periodontal tissue deteriorates under persistent oxidative stress induced by inflammatory reactions in the microflora of the oral cavity. This study aimed to…”
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Skin Effect Suppressed Ni-Fe/Cu Electroplated Multilayer Wiring for High Data-Rate and Low Delay-Time I/O Interface Board by Yamaguchi, Masahiro, Yanai, Takeshi, Nakayama, Hidetoshi, Sai, Ranajit, Fujiwara, Hiroaki, Kitai, Yuki, Sato, Mikio, Sangawa, Ushio

“…Application of negative permeability beyond ferromagnetic resonance frequency is discussed in this paper. Targeted application is the skin effect suppression…”
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Synthetic Studies toward Isoschizogamine: Construction of Pentacyclic Core Structure by Tokuyama, Hidetoshi, Sugimoto, Kenji, Fujiwara, Hiroaki, Takada, Akihiro, Kim, Dong-Gil, Ueda, Hirofumi

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STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma by NAHER, LUTFUN, KIYOSHIMA, TAMOTSU, KOBAYASHI, IEYOSHI, WADA, HIROKO, NAGATA, KENGO, FUJIWARA, HIROAKI, OOKUMA, YUKIKO F, OZEKI, SATORU, NAKAMURA, SEIJI, SAKAI, HIDETAKA

“…Interleukin (IL)-22 is a member of the IL-10 family. Its main targets are epithelial cells, not immune cells. We examined IL-22 signal transduction in oral…”
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Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis by KATO, HIROYUKI, TATEISHI, KEISUKE, FUJIWARA, HIROAKI, IJICHI, HIDEAKI, YAMAMOTO, KEISUKE, NAKATSUKA, TAKUMA, KAKIUCHI, MIWAKO, SANO, MAKOTO, KUDO, YOTARO, HAYAKAWA, YOKU, NAKAGAWA, HAYATO, TANAKA, YASUO, OTSUKA, MOTOYUKI, HIRATA, YOSHIHIRO, TACHIBANA, MAKOTO, SHINKAI, YOICHI, KOIKE, KAZUHIKO

“…Background/Aim: The entire mechanisms by which epigenetic modifiers contribute to the development of pancreatic cancer remain unknown. Although the histone…”
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