Search Results - "FUJITA, Tetsuro"

Radiofrequency ablation of hyperplasia at an uncovered portion of a partially covered metal stent in endoscopic ultrasound‐guided hepaticogastrostomy (with video) by Matsubara, Saburo, Nakagawa, Keito, Suda, Kentaro, Fujita, Tetsuro, Otsuka, Takeshi, Oka, Masashi, Nagoshi, Sumiko

“…Highlight Endoscopic ultrasound‐guided hepaticogastrostomy with a partially covered metal stent has a potential risk of stent occlusion due to hyperplasia at…”
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Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells by Nagaoka, Yasuo, Otsuki, Kota, Fujita, Tetsuro, Uesato, Shinichi

“…FTY720 (fingolimod), a novel immunosuppressant, was found to become biologically activated by phosphorylation into FTY720-1-phosphate (FTY720-P), which is a…”
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Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model by Yoshida, Yuya, Mikami, Norihisa, Matsushima, Yuki, Otani, Fumiya, Miyawaki, Mai, Takatsuji, Miku, Banno, Rie, Tsuji, Takumi, Fujita, Tetsuro, Tsujikawa, Kazutake, Kohno, Takeyuki

“…We previously reported that combination treatment with fingolimod (FTY720) plus antigenic peptide of glucose-6-phosphate isomerase (residues 325–339)…”
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Efficacy of Combination Treatment with Fingolimod (FTY720) Plus Pathogenic Autoantigen in a Glucose-6-phosphate Isomerase Peptide (GPI325–339)-Induced Arthritis Mouse Model by Yoshida, Yuya, Tsuji, Takumi, Watanabe, Sayaka, Matsushima, Ayane, Matsushima, Yuki, Banno, Rie, Fujita, Tetsuro, Kohno, Takeyuki

“…Fingolimod (FTY720) is known to have a significant therapeutic effect in various autoimmune disease models. Here, we examined FTY720 in a model of rheumatoid…”
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Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice by Tsuji, Takumi, Okuno, Satoshi, Kuroda, Ayano, Hamazaki, Junya, Chikami, Takuma, Sakurai, Sakura, Yoshida, Yuya, Banno, Rie, Fujita, Tetsuro, Kohno, Takeyuki

“…The increasing incidence and prevalence of atopic dermatitis (AD) demands new therapeutic approaches for treating the disease. We investigated the therapeutic…”
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Therapeutic Approach to Steroid-Resistant Dermatitis Using Novel Immunomodulator FTY720 (Fingolimod) in Combination with Betamethasone Ointment in NC/Nga Mice by Tsuji, Takumi, Yoshida, Yuya, Iwatsuki, Rumi, Inoue, Mariko, Fujita, Tetsuro, Kohno, Takeyuki

“…The therapeutic efficacy of the novel immunomodulator FTY720 (Fingolimod), alone and in combination with betamethasone ointment, was examined in the NC/Nga…”
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Relapse of Experimental Autoimmune Encephalomyelitis after Discontinuation of FTY720 (Fingolimod) Treatment, but Not after Combination of FTY720 and Pathogenic Autoantigen by Yoshida, Yuya, Tsuji, Takumi, Fujita, Tetsuro, Kohno, Takeyuki

“…FTY720 (Fingolimod) is known to have a significant therapeutic effect on experimental autoimmune encephalomyelitis (EAE). Here, we used an EAE mouse model,…”
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The Essential Structures of ISP-I that Influence Serine Palmitoyltransferase Inhibition in Chinese Hamster Ovary Cells by Mizukoshi, Koji, Matsumoto, Katsuo, Hirose, Ryoji, Fujita, Tetsuro

“…We investigated the structure-activity relationship between various ISP-I (myriocin, thermozymocidin) analogous which has sphingosine-like structure and serine…”
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Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols by Kiuchi, Masatoshi, Adachi, Kunitomo, Kohara, Toshiyuki, Minoguchi, Masanori, Hanano, Tokushi, Aoki, Yoshiyuki, Mishina, Tadashi, Arita, Masafumi, Nakao, Noriyoshi, Ohtsuki, Makio, Hoshino, Yukio, Teshima, Koji, Chiba, Kenji, Sasaki, Shigeo, Fujita, Tetsuro

“…A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat…”
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The Effects of Serine Palmitoyltransferase Inhibitor, ISP-I, on UV-Induced Barrier Disruption in the Stratum Corneum by Mizukoshi, Koji, Oshima, Hiroshi, Matsumoto, Katsuo, Hirose, Ryouji, Fujita, Tetsuro

“…We examined the effects of ISP-I (myriocin, thermozymocidin)—a potent inhibitor of serine palmitoyltransferase (SPT) which is involved in the ceramide…”
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Effects of Serine Palmitoyltransferase Inhibitor ISP-I on the Stratum Corneum of Intact Mouse Skin by Mizukoshi, Koji, Matsumoto, Katsuo, Hirose, Ryouji, Fujita, Tetsuro, Ishida-Yamamoto, Akemi, Iizuka, Hajime

“…Serine palmitoyltransferase (SPT) is involved in the ceramide synthesis pathway. We investigated the effects of ISP-I, a potent inhibitor of SPT, on the…”
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Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains by Yeşilada, Erdem, Honda, Gisho, Sezik, Ekrem, Tabata, Mamoru, Fujita, Tetsuro, Tanaka, Toshihiro, Takeda, Yoshio, Takaishi, Yoshihisa

“…Folk medicine in the inner region of the Taurus Mountains in south Anatolia has been studied; 256 remedies prepared from 124 plant and 3 animal species are…”
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Sli2 (Ypk1), a Homologue of Mammalian Protein Kinase SGK, Is a Downstream Kinase in the Sphingolipid-Mediated Signaling Pathway of Yeast by Sun, Yidi, Taniguchi, Ritsuko, Tanoue, Daisuke, Yamaji, Toshiyuki, Takematsu, Hiromu, Mori, Kazutoshi, Fujita, Tetsuro, Kawasaki, Toshisuke, Kozutsumi, Yasunori

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice by Kohno, Takeyuki, Tsuji, Takumi, Hirayama, Kaori, Watabe, Kazuhito, Matsumoto, Akiko, Kohno, Tomoko, Fujita, Tetsuro

“…Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice…”
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The Essential Structures of ISP-I that Influence Serine Palmitoyltransferase Inhibition in Chinese Hamster Ovary Cells by Koji Mizukoshi, Katsuo Matsumoto, Ryoji Hirose, Tetsuro Fujita

“…We investigated the structure-activity relationship between various ISP-I (myriocin, thermozymocidin) analogous which has sphingosine-like structure and serine…”
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Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720 by Adachi, Kunitomo, Kohara, Toshiyuki, Nakao, Noriyoshi, Arita, Masafumi, Chiba, Kenji, Mishina, Tadashi, Sasaki, Shigeo, Fujita, Tetsuro

“…FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin,…”
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Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod) by Matsumoto, Norimasa, Hirose, Ryoji, Sasaki, Shigeo, Fujita, Tetsuro

“…The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was…”
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Mechanism of induction of immune tolerance in experimental autoimmune encephalomyelitis by combination treatment with fingolimod plus pathogenic autoantigen by Yoshida, Yuya, Mikami, Norihisa, Tsuji, Takumi, Takada, Yuki, Nakazawa, Yuka, Dan, Rie, Takatsuji, Miku, Fujita, Tetsuro, Tsujikawa, Kazutake, Kohno, Takeyuki

“…Objective We previously reported that relapse of experimental autoimmune encephalomyelitis (EAE) occurred approximately 1 week after discontinuation of…”
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A Novel Immunomodulator, FTY720, Prevents Development of Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice by Kohno, Takeyuki, Tsuji, Takumi, Hirayama, Kaori, Iwatsuki, Rumi, Hirose, Michitaka, Watabe, Kazuhito, Yoshikawa, Hiroaki, Kohno, Tomoko, Matsumoto, Akiko, Fujita, Tetsuro, Hayashi, Masatoshi

“…Prophylactic oral administration of a novel immunomodulator (immunosuppressant), FTY720 (1 mg/kg, three times a week), completely prevented the development of…”
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Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite by Fujita, T, Inoue, K, Yamamoto, S, Ikumoto, T, Sasaki, S, Toyama, R, Chiba, K, Hoshino, Y, Okumoto, T

“…A potent immunosuppressive activity was found in the culture broth of the fungus Isaria sinclairii (ATCC 24400). The metabolite, ISP-I…”
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