Search Results - "FUJITA, Teizo"

Evolution of the lectin-complement pathway and its role in innate immunity by Fujita, Teizo

“…Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a strategy of innate immunity that is found in both vertebrates and…”
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Factor D by Sekine, Hideharu, Machida, Takeshi, Fujita, Teizo

“…Summary Complement factor D (FD) is a serine protease that plays an essential role in the activation of the alternative pathway (AP) by cleaving complement…”
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The role of ficolins in the lectin pathway of innate immunity by Endo, Yuichi, Matsushita, Misao, Fujita, Teizo

“…Ficolins are a family of oligomeric proteins consisting of an N-terminal collagen-like domain and a C-terminal globular fibrinogen-like domain. They are novel…”
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Response to Comment on "Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway" by Machida, Takeshi, Hayashi, Manabu, Fujita, Teizo, Sekine, Hideharu

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Lectin pathway effector enzyme mannan‐binding lectin‐associated serine protease‐2 can activate native complement C3 in absence of C4 and/or C2 by Yaseen, Sadam, Demopulos, Gregory, Dudler, Thomas, Yabuki, Munehisa, Wood, Christi L., Cummings, W. Jason, Tjoelker, Larry W., Fujita, Teizo, Sacks, Steven, Garred, Peter, Andrew, Peter, Sim, Robert B., Lachmann, Peter J., Wallis, Russell, Lynch, Nicholas, Schwaeble, Wilhelm J.

“…ABSTRACT All 3 activation pathways of complement—the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)— converge into a common central…”
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The lectin-complement pathway - its role in innate immunity and evolution by Fujita, Teizo, Matsushita, Misao, Endo, Yuichi

“…Innate immunity was formerly thought to be a non‐specific immune response characterized by phagocytosis. However, innate immunity has considerable specificity…”
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The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway by Iwaki, Daisuke, Kanno, Kazuko, Takahashi, Minoru, Endo, Yuichi, Matsushita, Misao, Fujita, Teizo

“…Mannose-binding lectin (MBL)-associated serine proteases (MASPs) are responsible for activation of the lectin complement pathway. Three types of MASPs (MASP-1,…”
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Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway by Hayashi, Manabu, Machida, Takeshi, Ishida, Yumi, Ogata, Yusuke, Omori, Tomoko, Takasumi, Mika, Endo, Yuichi, Suzuki, Toshiyuki, Sekimata, Masayuki, Homma, Yoshimi, Ikawa, Masahito, Ohira, Hiromasa, Fujita, Teizo, Sekine, Hideharu

“…The complement system, a part of the innate immune system, can be activated via three different pathways. In the alternative pathway, a factor D (FD) plays…”
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Structural and Functional Overview of the Lectin Complement Pathway: Its Molecular Basis and Physiological Implication by Matsushita, Misao, Endo, Yuichi, Fujita, Teizo

“…The complement system is an effector mechanism in immunity. It is activated in three ways, the classical, alternative and lectin pathways. The lectin pathway…”
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Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D by Takahashi, Minoru, Ishida, Yumi, Iwaki, Daisuke, Kanno, Kazuko, Suzuki, Toshiyuki, Endo, Yuichi, Homma, Yoshimi, Fujita, Teizo

“…The complement system is an essential component of innate immunity, participating in the pathogenesis of inflammatory diseases and in host defense. In the…”
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Complement drives Th17 cell differentiation and triggers autoimmune arthritis by Hashimoto, Motomu, Hirota, Keiji, Yoshitomi, Hiroyuki, Maeda, Shinji, Teradaira, Shin, Akizuki, Shuji, Prieto-Martin, Paz, Nomura, Takashi, Sakaguchi, Noriko, Köhl, Jörg, Heyman, Birgitta, Takahashi, Minoru, Fujita, Teizo, Mimori, Tsuneyo, Sakaguchi, Shimon

“…Activation of serum complement triggers Th17 cell-dependent spontaneous autoimmune disease in an animal model. In genetically autoimmune-prone SKG mice,…”
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The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation by Kusakari, Kohei, Machida, Takeshi, Ishida, Yumi, Omori, Tomoko, Suzuki, Toshiyuki, Sekimata, Masayuki, Wada, Ikuo, Fujita, Teizo, Sekine, Hideharu

“…The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that…”
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Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/ lpr Mice by Machida, Takeshi, Sakamoto, Natsumi, Ishida, Yumi, Takahashi, Minoru, Fujita, Teizo, Sekine, Hideharu

“…The complement system, composed of the three activation pathways, has both protective and pathogenic roles in the development of systemic lupus erythematosus…”
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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury by Schwaeble, Wilhelm J, Lynch, Nicholas J, Clark, James E, Marber, Michael, Samani, Nilesh J, Ali, Youssif Mohammed, Dudler, Thomas, Parent, Brian, Lhotta, Karl, Wallis, Russell, Farrar, Conrad A, Sacks, Steven, Lee, Haekyung, Zhang, Ming, Iwaki, Daisuke, Takahashi, Minoru, Fujita, Teizo, Tedford, Clark E, Stover, Cordula M

“…Complement research experienced a renaissance with the discovery of a third activation route, the lectin pathway. We developed a unique model of total lectin…”
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A novel complement inhibitor sMAP‐FH targeting both the lectin and alternative complement pathways by Takasumi, Mika, Omori, Tomoko, Machida, Takeshi, Ishida, Yumi, Hayashi, Manabu, Suzuki, Toshiyuki, Homma, Yoshimi, Endo, Yuichi, Takahashi, Minoru, Ohira, Hiromasa, Fujita, Teizo, Sekine, Hideharu

“…Inhibition of the complement activation has emerged as an option for treatment of a range of diseases. Activation of the lectin and alternative pathways (LP…”
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The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection by Ali, Youssif M, Lynch, Nicholas J, Haleem, Kashif S, Fujita, Teizo, Endo, Yuichi, Hansen, Soren, Holmskov, Uffe, Takahashi, Kazue, Stahl, Gregory L, Dudler, Thomas, Girija, Umakhanth V, Wallis, Russell, Kadioglu, Aras, Stover, Cordula M, Andrew, Peter W, Schwaeble, Wilhelm J

“…The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin…”
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Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1 by Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, Cummings, W Jason, Takahashi, Minoru, Fujita, Teizo, Demopulos, Gregory, De Simoni, Maria-Grazia, Schwaeble, Wilhelm

“…Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing…”
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Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy by Gavriilaki, Eleni, Ho, Vincent T, Schwaeble, Wilhelm, Dudler, Thomas, Daha, Mohamed, Fujita, Teizo, Jodele, Sonata

“…Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric…”
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Role of ficolin in innate immunity and its molecular basis by Endo, Yuichi, Matsushita, Misao, Fujita, Teizo

“…Abstract Ficolin is a multimeric protein consisting of an N-terminal collagen-like domain and a C-terminal fibrinogen-like domain. The structure is similar to…”
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Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis by La Bonte, Laura R, Pavlov, Vasile I, Tan, Ying S, Takahashi, Kazue, Takahashi, Minoru, Banda, Nirmal K, Zou, Chenhui, Fujita, Teizo, Stahl, Gregory L

“…Bleeding disorders and thrombotic complications constitute a major cause of death and disability worldwide. Although it is known that the complement and…”
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