Search Results - "FUJITA, TOSHIRO"

Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome by Fujita, Toshiro

“…Obese persons with metabolic syndrome often have associated with salt-sensitive hypertension, microalbuminuria, and cardiac dysfunction, and the plasma…”
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The Role of Aldosterone in Obesity-Related Hypertension by Kawarazaki, Wakako, Fujita, Toshiro

“…Obese subjects often have hypertension and related cardiovascular and renal diseases, and this has become a serious worldwide health problem. In obese…”
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Kidney and epigenetic mechanisms of salt-sensitive hypertension by Kawarazaki, Wakako, Fujita, Toshiro

“…Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs between individuals. The interplay of ageing, genetics and…”
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The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury by Ayuzawa, Nobuhiro, Fujita, Toshiro

“…Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt…”
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Evaluation of the pathophysiological mechanisms of salt-sensitive hypertension by Hirohama, Daigoro, Fujita, Toshiro

“…The currently available data have indicated that dietary salt is directly correlated with blood pressure (BP) and the occurrence of hypertension. However, the…”
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Role of Rho in Salt-Sensitive Hypertension by Kawarazaki, Wakako, Fujita, Toshiro

“…A high amount of salt in the diet increases blood pressure (BP) and leads to salt-sensitive hypertension in individuals with impaired renal sodium excretion…”
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Renal mechanisms of salt-sensitive hypertension: contribution of two steroid receptor-associated pathways by Nishimoto, Mitsuhiro, Fujita, Toshiro

“…Although salt is a major environmental factor in the development of hypertension, the degree of salt sensitivity varies widely among individuals. The…”
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Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency by Kawarazaki, Wakako, Mizuno, Risuke, Nishimoto, Mitsuhiro, Ayuzawa, Nobuhiro, Hirohama, Daigoro, Ueda, Kohei, Kawakami-Mori, Fumiko, Oba, Shigeyoshi, Marumo, Takeshi, Fujita, Toshiro

“…Aging is associated with a high prevalence of hypertension due to elevated susceptibility of BP to dietary salt, but its mechanism is unknown. Serum levels of…”
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Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency by Jimbo, Rika, Kawakami-Mori, Fumiko, Mu, Shengyu, Hirohama, Daigoro, Majtan, Bohumil, Shimizu, Yuichiro, Yatomi, Yutaka, Fukumoto, Seiji, Fujita, Toshiro, Shimosawa, Tatsuo

“…Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there…”
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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease by Fujita, Toshiro, Shibata, Shigeru, Nagase, Miki, Yoshida, Shigetaka, Kawarazaki, Wakako, Kurihara, Hidetake, Tanaka, Hirotoshi, Miyoshi, Jun, Takai, Yoshimi

“…Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of proteinuric kidney diseases. However, little is known about the…”
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Pathophysiology of salt sensitivity hypertension by Ando, Katsuyuki, Fujita, Toshiro

“…Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual…”
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Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-β1 in human renal epithelial cells by YOSHIKAWA, Masahiro, HISHIKAWA, Keiichi, MARUMO, Takeshi, FUJITA, Toshiro

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Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study by Nishimoto, Mitsuhiro, Ohtsu, Hiroshi, Marumo, Takeshi, Kawarazaki, Wakako, Ayuzawa, Nobuhiro, Ueda, Kohei, Hirohama, Daigoro, Kawakami-Mori, Fumiko, Shibata, Shigeru, Nagase, Miki, Isshiki, Masashi, Oba, Shigeyoshi, Shimosawa, Tatsuo, Fujita, Toshiro

“…Excessive dietary salt intake can counteract the renoprotective effects of renin-angiotensin system (RAS) blockade in hypertensive patients with chronic kidney…”
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Rac1 deficiency impairs postnatal development of the renal papilla by Ayuzawa, Nobuhiro, Nishimoto, Mitsuhiro, Kawarazaki, Wakako, Oba, Shigeyoshi, Marumo, Takeshi, Aiba, Atsu, Fujita, Toshiro

“…Development of the renal medulla continues after birth to form mature renal papilla and obtain urine-concentrating ability. Here, we found that a small GTPase,…”
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Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner by Koizumi, Masahiro, Ueda, Kohei, Niimura, Fumio, Nishiyama, Akira, Yanagita, Motoko, Saito, Akihiko, Pastan, Ira, Fujita, Toshiro, Fukagawa, Masafumi, Matsusaka, Taiji

“…We have previously shown that podocyte injury increases the glomerular filtration of liver-derived Agt (angiotensinogen) and the generation of intrarenal Ang…”
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Two Mineralocorticoid Receptor-Mediated Mechanisms of Pendrin Activation in Distal Nephrons by Ayuzawa, Nobuhiro, Nishimoto, Mitsuhiro, Ueda, Kohei, Hirohama, Daigoro, Kawarazaki, Wakako, Shimosawa, Tatsuo, Marumo, Takeshi, Fujita, Toshiro

“…Regulation of sodium chloride transport in the aldosterone-sensitive distal nephron is essential for fluid homeostasis and BP control. The chloride-bicarbonate…”
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Hypokalemia and Pendrin Induction by Aldosterone by Xu, Ning, Hirohama, Daigoro, Ishizawa, Kenichi, Chang, Wen Xiu, Shimosawa, Tatsuo, Fujita, Toshiro, Uchida, Shunya, Shibata, Shigeru

“…Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na channel, Na-Cl cotransporter, and Cl/HCO3 exchanger…”
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Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney by Marumo, Takeshi, Yagi, Shintaro, Kawarazaki, Wakako, Nishimoto, Mitsuhiro, Ayuzawa, Nobuhiro, Watanabe, Atsushi, Ueda, Kohei, Hirahashi, Junichi, Hishikawa, Keiichi, Sakurai, Hiroyuki, Shiota, Kunio, Fujita, Toshiro

“…Epigenetic mechanisms may underlie the progression of diabetic kidney disease. Because the kidney is a heterogeneous organ with different cell types, we…”
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Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit by Doi, Kent, Negishi, Kousuke, Ishizu, Tomoko, Katagiri, Daisuke, Fujita, Toshiro, Matsubara, Takehiro, Yahagi, Naoki, Sugaya, Takeshi, Noiri, Eisei

“…OBJECTIVE:Biomarkers for detection of acute kidney injury and prediction of mortality will be useful to improve the outcomes of critically ill patients…”
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Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury by Ayuzawa, Nobuhiro, Nagase, Miki, Ueda, Kohei, Nishimoto, Mitsuhiro, Kawarazaki, Wakako, Marumo, Takeshi, Aiba, Atsu, Sakurai, Takayuki, Shindo, Takayuki, Fujita, Toshiro

“…There is increasing evidence for a crucial role of aberrant mineralocorticoid receptor (MR) activation in heart failure, with clinical studies showing…”
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