Search Results - "FUJII, SETSURO"

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species by Tsujita, Y, Kuroda, M, Shimada, Y, Tanzawa, K, Arai, M, Kaneko, I, Tanaka, M, Masuda, H, Tarumi, C, Watanabe, Y

“…CS-514 is a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme in cholesterol synthesis. For the microsomal enzyme…”
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Complete amino acid sequence of bovine colostrum low- Mr cysteine proteinase inhibitor by Hirado, Masayuki, Tsunasawa, Susumu, Sakiyama, Fumio, Niinobe, Michio, Fujii, Setsuro

“…The complete amino acid sequence of bovine colostrum cysteine proteinase inhibitor was determined by sequencing native inhibitor and peptides obtained by…”
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Antitumor Activity of BOF‐A2, a New 5‐Fluorouracil Derivative by Fujii, Setsuro, Fukushima, Masakazu, Shimamoto, Yuji, Ohshimo, Hideyuki, Imaoka, Takeshi, Shirasaka, Tetsuhiko

“…A compound containing both CNDP (3‐cyano‐2,6‐dihydroxypyridine), an inhibitor of 5‐fluorouracil (5‐FU) degradation, and EM‐FU (1‐ethoxymethyl‐5‐fluorouracil),…”
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Inhibitory effect of a new synthetic protease inhibitor (FUT-175) on the coagulation system by Hitomi, Y, Ikari, N, Fujii, S

“…The inhibitory effects of 6-amidino-2-naphthyl-4-guanidinobenzoate X dimethanesulfonate (FUT-175) on the human Hageman factor fragment (HFf), factor Xa,…”
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Synthesis of 5-Fluorouracil Derivatives Containing an Inhibitor of 5-Fluorouracil Degradation by HIROHASHI, Mitsuru, KIDO, Masaru, YAMAMOTO, Yoshihito, KOJIMA, Yutaka, JITSUKAWA, Koichiro, Fujii, Setsuro

“…The reactivities of 5-fluorouracil (5-FUra) degradation inhibitors, 2, 4- (2) and 2, 6-dihydroxypyridines (3), were investigated. Acylation of 2 and 2,…”
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Pharmacokinetic Modulation of Plasma 5‐Fluorouracil Concentrations to Potentiate the Antitumor Activity of Continuous Venous Infusion of 5‐Fluorouracil by Fujii, Setsuro, Fukushima, Masakazu, Shimamoto, Yuji, Shirasaka, Tetsuhiko

“…Methods for pharmacokinetic modulation of the plasma 5‐fluorouracil (5‐FU) level to increase antitumor activity during continuous venous infusion (CVI) of low…”
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Inhibition of various immunological reactions in vivo by a new synthetic complement inhibitor by Hitomi, Y, Fujii, S

“…FUT-175 (6 amidino-2-naphthyl-4-guanidino benzoate-dimethanesulfonate), a new synthetic protease inhibitor, inhibits the enzyme activities of various…”
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Purification and properties of aminopeptidase and arylamidase from human liver by Niinobe, M, Fujii, S

“…Aminopeptidase and arylamidase from human liver were purified 1,580- and 1,130-fold, respectively, by ammonium sulfate fractionation, TEAE-cellulose and…”
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Synthesis and structure-activity study of protease inhibitors. V: Chemical modification of 6-amidino-2-naphthyl-4-guanidinobenzoate by NAKAYAMA, T, TAIRA, S, IKEDA, M, ASHIZAWA, H, ODA, M, ARAKAWA, K, FUJII, S

“…By developing 6-amidino-2-naphthyl 4-guanidinobenzoate (I, FUT-175) as a basic structure, its various derivatives were synthesized and their inhibitory…”
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A sensitive colorimetric assay for various proteases using naphthyl ester derivatives as substrates by Niinobe, M, Hitomi, Y, Fujii, S

“…A convenient and highly sensitive colorimetric assay for various proteases, such as trypsin, chymotrypsin, plasmin, thrombin, and urokinase is described. The…”
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Purification of human plasma kallikrein and urokinase by affinity chromatography by Tamura, Y, Fujii, S

“…L-Homoarginine benzylester was coupled with Sepharose 4B and used for affinity chromatography of human plasma kallikrein [EC 3.4.21.8] and urokinase [EC…”
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High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur by Marunaka, T, Umeno, Y, Yoshida, K, Nagamachi, M, Minami, Y, Fujii, S

“…Oral administration of uracil plus ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] has a greater antitumor effect than that of ftorafur alone. A…”
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Cellular factors for stimulation of nucleosomal template activity for in vitro DNA synthesis by Akiyoshi, H, Fujii, S

“…Nucleosomes isolated from Yoshida sarcoma chromatin by micrococcal nuclease treatment were relatively inactive as templates for in vitro DNA synthesis…”
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Functional sites of bovine high molecular weight kininogen as a cofactor in kaolin-mediated activation of factor XII (Hageman factor) by Sugo, Teruko, Ikari, Nobuhiko, Kato, Hisao, Iwanaga, Sadaaki, Fujii, Setsuro

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Inhibitory Effects of Pyrimidine, Barbituric Acid and Pyridine Derivatives on 5-Fluorouracil Degradation in Rat Liver Extracts by TATSUMI, Kunihiko, FUKUSHIMA, Masakazu, SHIRASAKA, Tetsuhiko, FUJII, Setsuro

“…The inhibitory effects of about 30 compounds, mainly pyrimidine and pyridine derivatives, on 5-fluorouracil degradation catalyzed by dihydrouracil…”
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New synthetic inhibitors of chymotrypsin by Fujii, S, Yokoyama, T, Ikegaya, K, Yokoo, N

“…4-Substituted carbonylphenyl ester derivatives were prepared and their inhibitory effects on chymotrypsin, trypsin, thrombin, plasmin, pancreatic kallikrein,…”
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Relationship between lipase and esterase by Okuda, H, Fujii, S

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Studies on the Clinical Importance of Guanase Assayed by a Direct Colorimetric Method by YAMASAKI, SEIICHIRO, EGASHIRA, SHIZUMA, KOGA, MICHIHIRO, AKAGAWA, HARUO, FUJII, SETSURO

“…A direct colorimetric assay of ammonia liberated after a guanase reaction with 8 -azaguanine as substrate was tested using a guanase-assay kit (Maruho Co.,…”
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Studies of Hypolipidemic Agents. I. : Syntheses and Hypolipidemic Activities of 1-Substituted 2-Alkanone Derivatives by OGAWA, KAZUO, TERADA, TADAFUMI, MURANAKA, YOSHIYUKI, HAMAKAWA, TOSHIHIRO, HASHIMOTO, SADAO, FUJII, SETSURO

“…Many 1-substituted 2-alkanone derivatives were synthesized and their inhibitory activities toward pancreatic lipase and esterase were examined in order to…”
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Studies on lipolysis in lipid micelles isolated from adipose tissue by Saito, Y, Okuda, H, Fujii, S

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