Search Results - "FUJII, Hideaki"

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator by Meguro, Yoshiyuki, Miyano, Kanako, Hirayama, Shigeto, Yoshida, Yuki, Ishibashi, Naoto, Ogino, Takumi, Fujii, Yuriko, Manabe, Sei, Eto, Moeko, Nonaka, Miki, Fujii, Hideaki, Ueta, Yoichi, Narita, Minoru, Sata, Naohiro, Yada, Toshihiko, Uezono, Yasuhito

“…Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been…”
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Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists by Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi

“…Orexins are a family of neuropeptides that regulate sleep/wakefulness, acting on two G-protein-coupled receptors, orexin receptors 1 (OX1R) and 2 (OX2R)…”
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Surgical Resection of Hilar Cholangiocarcinoma: Analysis of Survival and Postoperative Complications by Hasegawa, Suguru, Ikai, Iwao, Fujii, Hideaki, Hatano, Etsuro, Shimahara, Yasuyuki

“…Background Surgery is the only potentially curative treatment for hilar bile duct cancer. This study sought to evaluate the efficacy and feasibility of…”
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The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis by Miyano, Kanako, Eto, Moeko, Hitomi, Suzuro, Matsumoto, Takashi, Hasegawa, Seiya, Hirano, Ayane, Nagabuchi, Kaori, Asai, Noriho, Uzu, Miaki, Nonaka, Miki, Omiya, Yuji, Kaneko, Atsushi, Ono, Kentaro, Fujii, Hideaki, Higami, Yoshikazu, Kono, Toru, Uezono, Yasuhito

“…Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the…”
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The Inhibition of TREK-1 K + Channels via Multiple Compounds Contained in the Six Kamikihito Components, Potentially Stimulating Oxytocin Neuron Pathways by Miyano, Kanako, Nonaka, Miki, Sakamoto, Masahiro, Murofushi, Mika, Yoshida, Yuki, Komura, Kyoko, Ohbuchi, Katsuya, Higami, Yoshikazu, Fujii, Hideaki, Uezono, Yasuhito

“…Oxytocin, a significant pleiotropic neuropeptide, regulates psychological stress adaptation and social communication, as well as peripheral actions, such as…”
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Essential structure of the κ opioid receptor agonist nalfurafine for binding to the κ receptor by Nagase, Hiroshi, Fujii, Hideaki

“…The selective κ opioid receptor agonist nalfurafine was launched in 2009 as an antipruritic drug for patients undergoing hemodialysis. It is the first…”
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Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127 by Moriya, Yuki, Kasahara, Yoshiyuki, Shimada, Masafumi, Sakakibara, Yasufumi, Fujii, Hideaki, Nagase, Hiroshi, Ide, Soichiro, Ikeda, Kazutaka, Hall, F. Scott, Uhl, George R., Sora, Ichiro

“…Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and…”
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In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways by Karasawa, Yusuke, Miyano, Kanako, Fujii, Hideaki, Mizuguchi, Takaaki, Kuroda, Yui, Nonaka, Miki, Komatsu, Akane, Ohshima, Kaori, Yamaguchi, Masahiro, Yamaguchi, Keisuke, Iseki, Masako, Uezono, Yasuhito, Hayashida, Masakazu

“…Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the…”
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Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol by Karaki, Fumika, Takamori, Taro, Kawakami, Koumei, Sakurai, Sae, Hidaka, Kyoko, Ishii, Kei, Oki, Tomoya, Sato, Noriko, Atsumi, Nao, Ashizawa, Karin, Taguchi, Ai, Ura, Asuka, Naruse, Toko, Hirayama, Shigeto, Nonaka, Miki, Miyano, Kanako, Uezono, Yasuhito, Fujii, Hideaki

“…In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the…”
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Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways by Yamaguchi, Masahiro, Miyano, Kanako, Hirayama, Shigeto, Karasawa, Yusuke, Ohshima, Kaori, Uezono, Eiko, Komatsu, Akane, Nonaka, Miki, Fujii, Hideaki, Yamaguchi, Keisuke, Iseki, Masako, Hayashida, Masakazu, Uezono, Yasuhito

“…Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is…”
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Reactivity of 7‐Azanorbornenes in Bioorthogonal Inverse Electron‐Demand Diels–Alder Reactions by Karaki, Fumika, Ohgane, Kenji, Imai, Hirotaka, Itoh, Kennosuke, Fujii, Hideaki

“…In the preparation of multicomponent compounds, the accumulation of components through sequential click reactions is an attractive strategy. In this work we…”
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Effects of N -Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives by Iwamatsu, Chiharu, Hayakawa, Daichi, Kono, Tomomi, Honjo, Ayaka, Ishizaki, Saki, Hirayama, Shigeto, Gouda, Hiroaki, Fujii, Hideaki

“…We have recently reported that -alkyl and -acyl naltrindole (NTI) derivatives showed activities for the δ opioid receptor (DOR) ranging widely from full…”
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The Japanese Herbal Medicine Hangeshashinto Induces Oral Keratinocyte Migration by Mediating the Expression of CXCL12 Through the Activation of Extracellular Signal-Regulated Kinase by Miyano, Kanako, Hasegawa, Seiya, Asai, Noriho, Uzu, Miaki, Yatsuoka, Wakako, Ueno, Takao, Nonaka, Miki, Fujii, Hideaki, Uezono, Yasuhito

“…Several clinical studies have reported that Japanese herbal medicine Hangeshashinto (HST) has beneficial effects on chemotherapy-induced oral ulcerative…”
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Structure–Activity Relationship Study of CYM51010, an agonist for the µ–δ Opioid Receptor Heterodimer by Watanabe, Ayaka, Yamada, Shuma, Yoshida, Haruka, Inagaki, Miku, Atsumi, Nao, Matsushima, Aoba, Takahashi, Naoki, Ishibashi, Naoto, Ogino, Takumi, Someya, Ryoto, Taguchi, Ai, Kagaya, Ryo, Ashizawa, Karin, Mendori, Hinako, Karasawa, Yusuke, Ohshima, Kaori, Yokoyama, Akinobu, Nonaka, Miki, Miyano, Kanako, Karaki, Fumika, Hirayama, Shigeto, Itoh, Kennosuke, Uezono, Yasuhito, Fujii, Hideaki

“…Although opioid analgesics are indispensable in treating pain, these drugs are accompanied by life-threatening side effects. While clinically relevant opioid…”
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The application of a specific morphinan template to the synthesis of galanthamine by Yamamoto, Naoshi, Okada, Takahiro, Harada, Yukimasa, Kutsumura, Noriki, Imaide, Satomi, Saitoh, Tsuyoshi, Fujii, Hideaki, Nagase, Hiroshi

“…(–)-Galanthamine (4) was synthesized from naltrexone (1) in 18 steps with 3% total yield by overcoming many specific side reactions derived from the…”
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Dipeptidyl peptidase-4 greatly contributes to the hydrolysis of vildagliptin in human liver by Asakura, Mitsutoshi, Fujii, Hideaki, Atsuda, Koichiro, Itoh, Tomoo, Fujiwara, Ryoichi

“…The major metabolic pathway of vildagliptin in mice, rats, dogs, and humans is hydrolysis at the cyano group to produce a carboxylic acid metabolite M20.7…”
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C-Homomorphinan Derivatives as Lead Compounds to Obtain Safer and More Clinically Useful Analgesics by Ishikawa, Kyoko, Karaki, Fumika, Tayama, Kaoru, Higashi, Eika, Hirayama, Shigeto, Itoh, Kennosuke, Fujii, Hideaki

“…Buprenorphine shows strong analgesic effects on moderate to severe pain. Although buprenorphine can be used more safely than other opioid analgesics, it has…”
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Vildagliptin and its metabolite M20.7 induce the expression of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells by Asakura, Mitsutoshi, Karaki, Fumika, Fujii, Hideaki, Atsuda, Koichiro, Itoh, Tomoo, Fujiwara, Ryoichi

“…Vildagliptin is a potent, orally active inhibitor of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes mellitus. It has been reported that…”
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Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives by Fujii, Hideaki, Shimada, Naoyuki, Ohtawa, Masaki, Karaki, Fumika, Koshizuka, Masayoshi, Hayashida, Kohei, Kamimura, Mitsuhiro, Makino, Kazuishi, Nagamitsu, Tohru, Nagase, Hiroshi

“…We applied a desilylation procedure using SO3H silica gel, with the surface modified by alkylsulfonic acid groups, to silylated sugar, nucleoside, and alkaloid…”
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Author Correction: The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis by Miyano, Kanako, Eto, Moeko, Hitomi, Suzuro, Matsumoto, Takashi, Hasegawa, Seiya, Hirano, Ayane, Nagabuchi, Kaori, Asai, Noriho, Uzu, Miaki, Nonaka, Miki, Omiya, Yuji, Kaneko, Atsushi, Ono, Kentaro, Fujii, Hideaki, Higami, Yoshikazu, Kono, Toru, Uezono, Yasuhito

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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