Search Results - "FUCHS Robert P"

Accidental Encounter of Repair Intermediates in Alkylated DNA May Lead to Double-Strand Breaks in Resting Cells by Fujii, Shingo, Fuchs, Robert P

“…In clinics, chemotherapy is often combined with surgery and radiation to increase the chances of curing cancers. In the case of glioblastoma (GBM), patients…”
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Tolerance of lesions in E. coli: Chronological competition between Translesion Synthesis and Damage Avoidance by Fuchs, Robert P.

“…Lesion tolerance pathways allow cells to proceed with replication despite the presence of replication-blocking lesions in their genome. Following transient…”
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Bacterial Proliferation: Keep Dividing and Don't Mind the Gap by Laureti, Luisa, Demol, Julien, Fuchs, Robert P, Pagès, Vincent

“…DNA Damage Tolerance (DDT) mechanisms help dealing with unrepaired DNA lesions that block replication and challenge genome integrity. Previous in vitro studies…”
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Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli by Gon, Stéphanie, Napolitano, Rita, Rocha, Walter, Coulon, Stéphane, Fuchs, Robert P

“…Exposure of Escherichia coli to UV light increases expression of NrdAB, the major ribonucleotide reductase leading to a moderate increase in dNTP levels. The…”
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Versatile and efficient chromatin pull-down methodology based on DNA triple helix formation by Isogawa, Asako, Fuchs, Robert P., Fujii, Shingo

“…The goal of present paper is to develop a reliable DNA-based method for isolation of protein complexes bound to DNA ( I solation of D NA A ssociated P roteins:…”
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PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching by Tsuda, Masataka, Ogawa, Saki, Ooka, Masato, Kobayashi, Kaori, Hirota, Kouji, Wakasugi, Mitsuo, Matsunaga, Tsukasa, Sakuma, Tetsushi, Yamamoto, Takashi, Chikuma, Shunsuke, Sasanuma, Hiroyuki, Debatisse, Michelle, Doherty, Aidan J, Fuchs, Robert P, Takeda, Shunichi

“…Replicative DNA polymerases are frequently stalled at damaged template strands. Stalled replication forks are restored by the DNA damage tolerance (DDT)…”
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Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide by Fuchs, Robert P, Isogawa, Asako, Paulo, Joao A, Onizuka, Kazumitsu, Takahashi, Tatsuro, Amunugama, Ravindra, Duxin, Julien P, Fujii, Shingo

“…Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts…”
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Pol V-Mediated Translesion Synthesis Elicits Localized Untargeted Mutagenesis during Post-replicative Gap Repair by Isogawa, Asako, Ong, Jennifer L., Potapov, Vladimir, Fuchs, Robert P., Fujii, Shingo

“…In vivo, replication forks proceed beyond replication-blocking lesions by way of downstream repriming, generating daughter strand gaps that are subsequently…”
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Gaps and forks in DNA replication: Rediscovering old models by Lehmann, Alan R., Fuchs, Robert P.

“…Most current models for replication past damaged lesions envisage that translesion synthesis occurs at the replication fork. However older models suggested…”
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Chronology in lesion tolerance gives priority to genetic variability by Naiman, Karel, Philippin, Gaëlle, Fuchs, Robert P., Pagès, Vincent

“…The encounter of a replication fork with a blocking DNA lesion is a common event that cells need to address properly to preserve genome integrity. Cells…”
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Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli by Janel-Bintz, Régine, Napolitano, Rita L, Isogawa, Asako, Fujii, Shingo, Fuchs, Robert P

“…It is generally assumed that most point mutations are fixed when damage containing template DNA undergoes replication, either right at the fork or behind the…”
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Biochemical basis for the essential genetic requirements of RecA and the β-clamp in Pol V activation by Fujii, Shingo, Fuchs, Robert P

“…In Escherichia coli, it is genetically well established that the β-clamp and RecA are essential cofactors that endow DNA polymerase (Pol) V with lesion bypass…”
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Enrichment of plasmid pool from E. coli for mass sequencing to detect untargeted mutagenic events by Isogawa, Asako, Fuchs, Robert P., Fujii, Shingo

“…Translesion synthesis (TLS) is an event to cope with DNA damages. During TLS, the responsible TLS polymerase frequently elicits untargeted mutagenesis as…”
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Monitoring bypass of single replication-blocking lesions by damage avoidance in the Escherichia coli chromosome by Pagès, Vincent, Mazón, Gerard, Naiman, Karel, Philippin, Gaëlle, Fuchs, Robert P

“…Although most deoxyribonucleic acid (DNA) lesions are accurately repaired before replication, replication across unrepaired lesions is the main source of point…”
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Defining the position of the switches between replicative and bypass DNA polymerases by Fujii, Shingo, Fuchs, Robert P

“…Cells contain specialized DNA polymerases that are able to copy past lesions with an associated risk of generating mutations, the major cause of cancer. Here,…”
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Uncoupling of Leading- and Lagging-Strand DNA Replication during Lesion Bypass in Vivo by Pagès, Vincent, Fuchs, Robert P.

“…Numerous agents attack DNA, forming lesions that impair normal replication. Specialized DNA polymerases transiently replace the replicative polymerase and copy…”
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Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo by Fujii, Shingo, Isogawa, Asako, Fuchs, Robert P.

“…Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere…”
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DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts by Ikeda, Mio, Furukohri, Asako, Philippin, Gaelle, Loechler, Edward, Akiyama, Masahiro Tatsumi, Katayama, Tsutomu, Fuchs, Robert P, Maki, Hisaji

“…Escherichia coli DNA polymerase IV (Pol IV, also known as DinB) is a Y-family DNA polymerase capable of catalyzing translesion DNA synthesis (TLS) on certain…”
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Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo by Fujii, Shingo, Isogawa, Asako, Fuchs, Robert P

“…Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere…”
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A Comprehensive View of Translesion Synthesis in Escherichia coli by Fujii, Shingo, Fuchs, Robert P

“…The lesion bypass pathway, translesion synthesis (TLS), exists in essentially all organisms and is considered a pathway for postreplicative gap repair and, at…”
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