Search Results - "FUCHS, S. C"

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology by Ogino, S, Lochhead, P, Giovannucci, E, Meyerhardt, J A, Fuchs, C S, Chan, A T

“…Regular use of aspirin reduces incidence and mortality of various cancers, including colorectal cancer. Anticancer effect of aspirin represents one of the…”
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A prospective study of plasma inflammatory markers and risk of colorectal cancer in men by Song, M, Wu, K, Ogino, S, Fuchs, C S, Giovannucci, E L, Chan, A T

“…Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC…”
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A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer by Kindler, H.L., Richards, D.A., Garbo, L.E., Garon, E.B., Stephenson, J.J., Rocha-Lima, C.M., Safran, H., Chan, D., Kocs, D.M., Galimi, F., McGreivy, J., Bray, S.L., Hei, Y., Feigal, E.G., Loh, E., Fuchs, C.S.

“…We evaluated the efficacy and safety of ganitumab (a mAb antagonist of insulin-like growth factor 1 receptor) or conatumumab (a mAb agonist of human death…”
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Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer by Souglakos, J, Philips, J, Wang, R, Marwah, S, Silver, M, Tzardi, M, Silver, J, Ogino, S, Hooshmand, S, Kwak, E, Freed, E, Meyerhardt, J A, Saridaki, Z, Georgoulias, V, Finkelstein, D, Fuchs, C S, Kulke, M H, Shivdasani, R A

“…Background: We address the prognostic and predictive value of KRAS , PIK3CA and BRAF mutations for clinical outcomes in response to active agents in the…”
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CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies by Ogino, S, Cantor, M, Kawasaki, T, Brahmandam, M, Kirkner, G J, Weisenberger, D J, Campan, M, Laird, P W, Loda, M, Fuchs, C S

“…Background: The concept of CpG island methylator phenotype (CIMP) is not universally accepted. Even if specific clinicopathological features have been…”
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Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer by Schernhammer, Eva S, Giovannucci, Edward, Kawasaki, Takako, Rosner, Bernard, Fuchs, Charles S, Ogino, Shuji

“…Although critical for methylation reactions, how dietary folate and B vitamins affect global DNA methylation level in colorectal cancers is currently unknown…”
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Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies by Bao, Y, Ng, K, Wolpin, B M, Michaud, D S, Giovannucci, E, Fuchs, C S

“…Background: Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results. Methods: We prospectively followed 118…”
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Night-Shift Work and Risk of Colorectal Cancer in the Nurses’ Health Study by Schernhammer, Eva S., Laden, Francine, Speizer, Frank E., Willett, Walter C., Hunter, David J., Kawachi, Ichiro, Fuchs, Charles S., Colditz, Graham A.

“…Exposure to light at night suppresses the physiologic production of melatonin, a hormone that has antiproliferative effects on intestinal cancers. Although…”
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Does psychosocial stress cause hypertension? A systematic review of observational studies by Sparrenberger, F, Cichelero, F T, Ascoli, A M, Fonseca, F P, Weiss, G, Berwanger, O, Fuchs, S C, Moreira, L B, Fuchs, F D

“…Acute stress promotes transient elevation of blood pressure, but there is no consistent evidence that this effect results in hypertension. In this systematic…”
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Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3 1 in colorectal cancer by Baba, Y, Nosho, K, Shima, K, Meyerhardt, J A, Chan, A T, Engelman, J A, Cantley, L C, Loda, M, Giovannucci, E, Fuchs, C S, Ogino, S

“…Background: AMP-activated protein kinase (AMPK, PRKA) has central roles in cellular metabolic sensing and energy balance homeostasis, and interacts with…”
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Nut consumption and risk of pancreatic cancer in women by Bao, Y, Hu, F B, Giovannucci, E L, Wolpin, B M, Stampfer, M J, Willett, W C, Fuchs, C S

“…Background: Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer. Methods: We…”
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A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma by Chan, J.A., Blaszkowsky, L.S., Enzinger, P.C., Ryan, D.P., Abrams, T.A., Zhu, A.X., Temel, J.S., Schrag, D., Bhargava, P., Meyerhardt, J.A., Wolpin, B.M., Fidias, P., Zheng, H., Florio, S., Regan, E., Fuchs, C.S.

“…Epidermal growth factor receptor (EGFR) is overexpressed in a significant proportion of esophageal and gastric carcinomas. Although previous studies have…”
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The role of conceptual frameworks in epidemiological analysis: a hierarchical approach by Victora, C G, Huttly, S R, Fuchs, S C, Olinto, M T

“…BACKGROUND: This paper discusses appropriate strategies for multivariate data analysis in epidemiological studies. METHODS: In studies where determinants of…”
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Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity by da Cunha, VR, Brenol, CV, Brenol, JCT, Fuchs, SC, Arlindo, EM, Melo, IMF, Machado, CA, de Castro Chaves, H, Xavier, RM

“…Objectives: To evaluate the prevalence of metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) vs. controls, and to verify possible…”
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Seasonal variation in food intake and the interaction effects of sex and age among adults in southern Brazil by Rossato, S L, Olinto, M T A, Henn, R L, Moreira, L B, Camey, S A, Anjos, L A, Wahrlich, V, Waissmann, W, Fuchs, F D, Fuchs, S C

“…Background/objectives: Because studies have evidenced variations in nutrient intake, further investigation of the interaction between demographic…”
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Health-related quality of life is worse in individuals with hypertension under drug treatment: results of population-based study by Trevisol, D J, Moreira, L B, Fuchs, F D, Fuchs, S C

“…Patients with hypertension usually report lower health-related quality of life (HRQoL), but it is unclear whether this is secondary to high blood pressure (BP)…”
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Plasma inflammatory cytokines and survival of pancreatic cancer patients by Babic, A, Schnure, N, Neupane, N P, Zaman, M M, Rifai, N, Welch, M W, Brais, L K, Rubinson, D A, Morales-Oyarvide, V, Yuan, C, Zhang, S, Poole, E M, Wolpin, B M, Kulke, M H, Barbie, D A, Wong, K, Fuchs, C S, Ng, K

“…Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal…”
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Body mass index and Barrett's oesophagus in women by Jacobson, B C, Chan, A T, Giovannucci, E L, Fuchs, C S

“…Excess body mass is associated with symptoms of gastro-oesophageal reflux disease, and cross-sectional studies suggest an association between body mass index…”
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Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastastic colorectal cancer by Meyerhardt, JA, Stuart, K, Fuchs, CS, Zhu, AX, Earle, CC, Bhargava, P, Blaszkowsky, L, Enzinger, P, Mayer, RJ, Battu, S, Lawrence, C, Ryan, DP

“…Background: Targeting the epidermal growth factor receptor and angiogenesis have proven useful strategies against metastatic colorectal cancer. The benefit of…”
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Impact of Patient and Provider Characteristics on the Treatment and Outcomes of Colorectal Cancer by Hodgson, David C., Fuchs, Charles S., Ayanian, John Z.

“…While the management and prognosis of colorectal cancer are largely dependent on clinical features such as tumor stage, there is considerable variation in…”
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