Search Results - "FRYXELL, Karl J"

BDNF mediates improvements in executive function following a 1-year exercise intervention by Leckie, Regina L, Oberlin, Lauren E, Voss, Michelle W, Prakash, Ruchika S, Szabo-Reed, Amanda, Chaddock-Heyman, Laura, Phillips, Siobhan M, Gothe, Neha P, Mailey, Emily, Vieira-Potter, Victoria J, Martin, Stephen A, Pence, Brandt D, Lin, Mingkuan, Parasuraman, Raja, Greenwood, Pamela M, Fryxell, Karl J, Woods, Jeffrey A, McAuley, Edward, Kramer, Arthur F, Erickson, Kirk I

“…Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which aerobic exercise may preserve executive…”
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CpG mutation rates in the human genome are highly dependent on local GC content by Fryxell, Karl J, Moon, Won-Jong

“…CpG dinucleotides mutate at a high rate because cytosine is vulnerable to deamination, cytosines in CpG dinucleotides are often methylated, and deamination of…”
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Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay by Locklear, Laura L., McDonald, Craig G., Smith, Robert F., Fryxell, Karl J.

“…Nicotine has both rewarding and aversive properties in rodents, as shown by intravenous self-administration, intracranial self-stimulation, and conditioned…”
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Both a Nicotinic Single Nucleotide Polymorphism (SNP) and a Noradrenergic SNP Modulate Working Memory Performance when Attention Is Manipulated by Greenwood, Pamela M, Sundararajan, Ramya, Lin, Ming-Kuan, Kumar, Reshma, Fryxell, Karl J, Parasuraman, Raja

“…We investigated the relation between the two systems of visuospatial attention and working memory by examining the effect of normal variation in cholinergic…”
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Nicotine preference and affective behavior of Cd81 knockout mice by Murphy, R. Logan, Locklear, Laura L., Niaz, M. Haris, Walton, Rebecca L., Hudson, Alexandra D., Fryxell, Karl J.

“…Rationale Cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine…”
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Effective antiprotease-antibiotic treatment of experimental anthrax by Popov, Serguei G, Popova, Taissia G, Hopkins, Svetlana, Weinstein, Raymond S, MacAfee, Rebecca, Fryxell, Karl J, Chandhoke, Vikas, Bailey, Charles, Alibek, Ken

“…Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic…”
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Healthy Aging Increases the Cognitive Effects of Two Genes That Influence Extracellular Dopamine by Greenwood, Pamela M., Lin, Ming-Kuan, Sundararajan, Ramya, Fryxell, Karl J., Parasuraman, Raja

“…We hypothesized that normal variation in genes influencing the bioavailability of dopamine in prefrontal cortex contribute to inter-individual differences in…”
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Cytosine deamination plays a primary role in the evolution of mammalian isochores by Fryxell, K J, Zuckerkandl, E

“…DNA melting is rate-limiting for cytosine deamination, from which we infer that the rate of cytosine deamination should decline twofold for each 10% increase…”
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Low-dose adolescent nicotine and methylphenidate have additive effects on adult behavior and neurochemistry by Wheeler, Tracey L., Smith, Laura N., Bachus, Susan E., McDonald, Craig G., Fryxell, Karl J., Smith, Robert F.

“…Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) have higher rates of smoking than adolescents without ADHD. Since methylphenidate is the…”
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Chronic Nicotine Doses Down-Regulate PDE4 Isoforms that Are Targets of Antidepressants in Adolescent Female Rats by Polesskaya, Oksana O, Smith, Robert F, Fryxell, Karl J

“…Background Previous data in humans and animal models has suggested connections between anxiety, depression, smoking behavior, and nicotine dependence. The…”
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The coevolution of gene family trees by Fryxell, Karl J.

“…Gene duplication mutants arise spontaneously at a high rate in bacteria, bacteriophages, insects and mammalian cells, and are generally viable. Thus, the…”
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Nicotine causes age-dependent changes in gene expression in the adolescent female rat brain by Polesskaya, Oksana O, Fryxell, Karl J, Merchant, Amita D, Locklear, Laura L, Ker, Ko-Fei, McDonald, Craig G, Eppolito, Amy K, Smith, Laura N, Wheeler, Tracey L, Smith, Robert F

“…Abstract Humans often start smoking during adolescence. Recent results suggest that rodents may also be particularly vulnerable to nicotine dependence during…”
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An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) by Fryxell, K J, Soderlund, M, Jordan, T V

“…CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited condition that causes repeated small-scale…”
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Healthy Aging Increases the Cognitive Effects of Two Genes That Influence Extracellular Dopamine : GENETICS OF COGNITIVE AGING by GREENWOOD, Pamela M, LIN, Ming-Kuan, SUNDARARAJAN, Ramya, FRYXELL, Karl J, PARASURAMAN, Raja

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Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats: Smoking and drinking: Insights into our most common addictions by POLESSKAYA, Oksana O, SMITH, Robert F, FRYXELL, Karl J

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Nicotine causes age-dependent changes in gene expression in the adolescent female rat brain: Special issue: Exposures during adolescent development: are neurotoxic risks increased? by POLESSKAYA, Oksana O, FRYXELL, Karl J, MERCHANT, Amita D, LOCKLEAR, Laura L, KER, Ko-Fei, MCDONALD, Craig G, EPPOLITO, Amy K, SMITH, Laura N, WHEELER, Tracey L, SMITH, Robert F

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An animal model for the molecular genetics of CADASIL / Editorial comment by Fryxell, Karl J, Soderlund, Marcus, Jordan, Theodor V, Verdi, Joseph M, Kubu, Christopher J

“…BACKGROUND: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited condition that causes repeated…”
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The evolutionary divergence of neurotransmitter receptors and second-messenger pathways by Fryxell, K J

“…Members of the superfamily of G-protein-coupled neurotransmitter receptors have a conserved secondary structure, a moderate and reasonably steady rate of…”
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An animal model for the molecular genetics of CADASIL. Commentary by FRYXELL, Karl J, SODERLUND, Marcus, JORDAN, Theodor V, VERDI, Joseph M, KUBU, Christopher J

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Synthesis of sulfatide by cultured rat Schwann cells by Fryxell, K J

“…The 35S sulfolipids synthesized by purified cultures of rat Schwann cells, fibroblasts, and a rat cell line (RN2) were studied. Schwann cell 35S sulfolipids…”
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