Search Results - "FRYE, F"

Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis by Kalavalapalli, Srilaxmi, Bril, Fernando, Koelmel, Jeremy P, Abdo, Kaitlyn, Guingab, Joy, Andrews, Paige, Li, Wen-Yi, Jose, Dhanya, Yost, Richard A, Frye, Reginald F, Garrett, Timothy J, Cusi, Kenneth, Sunny, Nishanth E

“…Pioglitazone is effective in improving insulin resistance and liver histology in patients with nonalcoholic steatohepatitis (NASH). Because dysfunctional…”
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Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea by An, Guohua, Mukker, Jatinder Kaur, Derendorf, Hartmut, Frye, Reginald F.

“…Beverage–drug interactions have remained an active area of research and have been the subject of extensive investigations in the past 2 decades. The known…”
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Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects by Le, MyPhuong T, Frye, Reginald F, Rivard, Christopher J, Cheng, Jing, McFann, Kim K, Segal, Mark S, Johnson, Richard J, Johnson, Julie A

“…Abstract It is unclear whether high-fructose corn syrup (HFCS), which contains a higher amount of fructose and provides an immediate source of free fructose,…”
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Inhibitory Effects of Commonly Used Herbal Extracts on UDP-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities by MOHAMED, Mohamed-Eslam F, FRYE, Reginald F

“…The aim of this study was to investigate the effect of commonly used botanicals on UDP-glucuronosyltransferase (UGT) 1A4, UGT1A6, and UGT1A9 activities in…”
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Effect of pterostilbene on in vitro drug metabolizing enzyme activity by Albassam, Ahmed A., Frye, Reginald F.

“…Pterostilbene is a natural polyphenol compound found in small berries that is related to resveratrol, but has better bioavailability and a longer half-life…”
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A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis by Kawaguchi-Suzuki, Marina, Cusi, Kenneth, Bril, Fernando, Gong, Yan, Langaee, Taimour, Frye, Reginald F

“…Pioglitazone is used effectively to treat non-alcoholic steatohepatitis (NASH), but there is marked variability in response. This study examined whether…”
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Pharmacometabolomics reveals racial differences in response to atenolol treatment by Wikoff, William R, Frye, Reginald F, Zhu, Hongjie, Gong, Yan, Boyle, Stephen, Churchill, Erik, Cooper-Dehoff, Rhonda M, Beitelshees, Amber L, Chapman, Arlene B, Fiehn, Oliver, Johnson, Julie A, Kaddurah-Daouk, Rima

“…Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially…”
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Concentration‐dependent response to pioglitazone in nonalcoholic steatohepatitis by Kawaguchi‐Suzuki, M., Bril, F., Kalavalapalli, S., Cusi, K., Frye, R. F.

“…Summary Background Pioglitazone is a safe and effective option to manage patients with type 2 diabetes and nonalcoholic steatohepatitis (NASH). However, there…”
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A sensitive and specific liquid chromatography–tandem mass spectrometry method for the determination of intracellular and extracellular uric acid by Kim, Kyung Mee, Henderson, George N., Ouyang, Xiaosen, Frye, Reginald F., Sautin, Yuri Y., Feig, Daniel I., Johnson, Richard J.

“…Uric acid (UA) is known to be a major biological antioxidant in plasma. However, there is a strong correlation between UA levels and cardiovascular risk…”
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Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid by Ginkgo biloba Extract and Flavonoids by MOHAMED, Mohamed-Eslam F, FRYE, Reginald F

“…Herb-drug interactions have received more attention in recent years because of the widespread popularity of herbal supplements. However, there are limited data…”
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Current clinical evidence on pioglitazone pharmacogenomics by Kawaguchi-Suzuki, Marina, Frye, Reginald F

“…Pioglitazone is the most widely used thiazolidinedione and acts as an insulin-sensitizer through activation of the Peroxisome Proliferator-Activated Receptor-γ…”
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The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects by Markowitz, John S., De Faria, Ludmila, Zhang, Qingchen, Melchert, Philip W., Frye, Reginald F., Klee, Brandon O., Qian, Yuli

“…Abstract Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical…”
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DHEA and DHEA-S: A Review by Kroboth, Patricia D., Salek, Firoozeh S., Pittenger, Amy L., Fabian, Tanya J., Frye, Reginald F.

“…Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin…”
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A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence by Mosley, Scott A., Kim, Sarah, El Rouby, Nihal, Lingineni, Karthik, Esteban, Valvanera Vozmediano, Gong, Yan, Chen, Yiqing, Estores, David, Feng, Kairui, Kim, Hyewon, Kinjo, Minori, Langaee, Taimour, Li, Zhichuan, Schmidt, Siegfried O. F., Johnson, Julie A., Frye, Reginald F., Fang, Lanyan (Lucy), Zhao, Liang, Binkley, Philip F., Schmidt, Stephan, Cavallari, Larisa H.

“…There are limited comparison data throughout the dosing interval for generic versus brand metoprolol extended‐release (ER) tablets. We compared the…”
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Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity by Mohamed, Mohamed-Eslam F., Tseng, Tiffany, Frye, Reginald F.

“…Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng,…”
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Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry by Kim, Kyung Mee, Henderson, George N., Frye, Reginald F., Galloway, Cheryl D., Brown, Nancy J., Segal, Mark S., Imaram, Witcha, Angerhofer, Alexander, Johnson, Richard J.

“…Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. UA can react…”
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Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics by Shahin, Mohamed H., Gong, Yan, Frye, Reginald F., Rotroff, Daniel M., Beitelshees, Amber L., Baillie, Rebecca A., Chapman, Arlene B., Gums, John G., Turner, Stephen T., Boerwinkle, Eric, Motsinger‐Reif, Alison, Fiehn, Oliver, Cooper‐DeHoff, Rhonda M., Han, Xianlin, Kaddurah‐Daouk, Rima, Johnson, Julie A.

“…Background Although hydrochlorothiazide (HCTZ) is a well‐established first‐line antihypertensive in the United States, <50% of HCTZ treated patients achieve…”
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Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats by Elewa, Hazem F, Kozak, Anna, El-Remessy, Azza B, Frye, Reginald F, Johnson, Maribeth H, Ergul, Adviye, Fagan, Susan C

“…Ischemic stroke is a leading cause of death in the United States, and diabetes mellitus is a major risk factor for stroke. Our previous work showed that type…”
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Bioequivalence revisited: Influence of age and sex on CYP enzymes by Bebia, Zourab, Buch, Shama C., Wilson, John W., Frye, Reginald F., Romkes, Marjorie, Cecchetti, Alfred, Chaves‐Gnecco, Diego, Branch, Robert A.

“…Background and objective The activity of cytochrome P450 (CYP) enzymes, which determine the rate of elimination of lipid‐soluble drugs, demonstrates…”
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Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes by Rotroff, DM, Shahin, MH, Gurley, SB, Zhu, H, Motsinger‐Reif, A, Meisner, M, Beitelshees, AL, Fiehn, O, Johnson, JA, Elbadawi‐Sidhu, M, Frye, RF, Gong, Y, Weng, L, Cooper‐DeHoff, RM, Kaddurah‐Daouk, R

“…Achieving hypertension (HTN) control and mitigating the adverse health effects associated with HTN continues to be a global challenge. Some individuals respond…”
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