Search Results - "FRUEN, B. R"

Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity by Zhao, F, Li, P, Chen, S R, Louis, C F, Fruen, B R

“…As an inhibitor of Ca(2+) release through ryanodine receptor (RYR) channels, the skeletal muscle relaxant dantrolene has proven to be both a valuable…”
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Regulation of the sarcoplasmic reticulum ryanodine receptor by inorganic phosphate by FRUEN, B. R, MICKELSON, J. R, SHOMER, N. H, ROGHAIR, T. J, LOUIS, C. F

“…To better understand the mechanisms regulating myoplasmic Ca2+ during muscle activity, we have examined the effect of inorganic phosphate (P(i)) on the…”
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Anions that potentiate excitation-contraction coupling may mimic effect of phosphate on Ca2+ release channel by Fruen, B R, Mickelson, J R, Roghair, T J, Cheng, H L, Louis, C F

“…Perchlorate is one of a group of inorganic anions that potentiate excitation-contraction coupling in skeletal muscle. We have compared the effect of…”
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Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors by Fruen, Bradley R., Mickelson, James R., Louis, Charles F.

“…The skeletal muscle relaxant dantrolene inhibits the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling and suppresses the…”
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High-affinity [3H]inositol uptake by dissociated brain cells and cultured fibroblasts from fetal mice by FRUEN, B. R, LESTER, B. R

“…The accumulation of [3H]inositol by mechanically dissociated brain cells and cultured skin fibroblasts from fetal mice was examined. Uptake by both tissues was…”
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Down's syndrome fibroblasts exhibit enhanced inositol uptake by Fruen, B R, Lester, B R

“…The inositol metabolism of Down's syndrome (DS, trisomy 21) skin fibroblasts was examined. We report that DS cells accumulated [3H]inositol 2-3-fold faster…”
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Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation by Louis, C F, Balog, E M, Fruen, B R

“…Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle characterized by muscle contracture and life-threatening hypermetabolic crisis…”
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Role of calmodulin methionine residues in mediating productive association with cardiac ryanodine receptors by Balog, Edward M, Norton, Laura E, Thomas, David D, Fruen, Bradley R

“…Calmodulin (CaM) binds to the cardiac ryanodine receptor Ca2+ release channel (RyR2) with high affinity and may act as a regulatory channel subunit. Here we…”
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Calmodulin Oxidation and Methionine to Glutamine Substitutions Reveal Methionine Residues Critical for Functional Interaction with Ryanodine Receptor-1 by Balog, Edward M., Norton, Laura E., Bloomquist, Rachel A., Cornea, Razvan L., Black, D.J., Louis, Charles F., Thomas, David D., Fruen, Bradley R.

“…Calmodulin (CaM) binds to the skeletal muscle ryanodine receptor Ca2+ release channel (RyR1) with high affinity, and it may act as a Ca2+-sensing subunit of…”
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Cyclic ADP-ribose does not affect cardiac or skeletal muscle ryanodine receptors by Fruen, Bradley R., Mickelson, James R., Shomer, Nirah H., Velez, Patricio, Louis, Charles F.

“…The cardiac muscle isoform of the ryanodine receptor/Ca 2+ release channel (RYR) has been proposed to be an important target of cyclic ADP-ribose (cADPR)…”
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Chloride-dependent sarcoplasmic reticulum Ca2+ release correlates with increased Ca2+ activation of ryanodine receptors by Fruen, B.R., Kane, P.K., Mickelson, J.R., Louis, C.F.

“…The mechanism by which chloride increases sarcoplasmic reticulum (SR) Ca2+ permeability was investigated. In the presence of 3 microM Ca2+, Ca2+ release from…”
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Effects of propofol on Ca2+ regulation by malignant hyperthermia-susceptible muscle membranes by FRUEN, B. R, MICKELSON, J. R, ROGHAIR, T. J, LITTERER, L. A, LOUIS, C. F

“…The effects of inhalation anesthetics on Ca2+ regulation in malignant hyperthermia-susceptible skeletal muscle are considered to be responsible for triggering…”
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Differential Ca(2+) sensitivity of skeletal and cardiac muscle ryanodine receptors in the presence of calmodulin by Fruen, B R, Bardy, J M, Byrem, T M, Strasburg, G M, Louis, C F

“…Calmodulin (CaM) activates the skeletal muscle ryanodine receptor Ca(2+) release channel (RyR1) in the presence of nanomolar Ca(2+) concentrations. However,…”
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The action of perchlorate on malignant-hyperthermia-susceptible muscle by Anderson, L C, Fruen, B R, Jordan, R C, Louis, C F, Gallant, E M

“…To better understand the altered skeletal muscle excitation-contraction (E-C) coupling that occurs in malignant hyperthermia, we have examined the potentiating…”
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Inositol and inositol 1,4,5-trisphosphate content of Down syndrome fibroblasts exhibiting enhanced inositol uptake by Fruen, Bradley R., Lester, Bruce R.

“…Fibroblasts from individuals with Down syndrome (DS; trisomy 21) exhibit increased inositol uptake. Here we examine the relationship between this increase in…”
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Direct Detection of Calmodulin Tuning by Ryanodine Receptor Channel Targets Using a Ca super(2+)-Sensitive Acrylodan-Labeled Calmodulin by Fruen, B R, Balog, E M, Schafer, J, Nitu, FR, Thomas, D D, Cornea, R L

“…Calmodulin (CaM) activates the skeletal muscle ryanodine receptor (RyR1) at nanomolar Ca super(2+) concentrations but inhibits it at micromolar Ca super(2+)…”
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Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1 by Balog, E M, Fruen, B R, Shomer, N H, Louis, C F

“…The sarcoplasmic reticulum (SR) Ca(2+) release channel (RyR1) from malignant hyperthermia-susceptible (MHS) porcine skeletal muscle has a decreased sensitivity…”
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Calmodulin Dissociation Mediates Desensitization of the cADPR-Induced Ca super(2+) Release Mechanism by Thomas, J M, Summerhill, R J, Fruen, B R, Churchill, G C, Galione, A

“…Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization. Though poorly understood, this "switching off"…”
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Mechanisms of P(i) regulation of the skeletal muscle SR Ca(2+) release channel by Balog, E M, Fruen, B R, Kane, P K, Louis, C F

“…Inorganic phosphate (P(i)) accumulates in the fibers of actively working muscle where it acts at various sites to modulate contraction. To characterize the…”
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Dantrolene Inhibition of Ryanodine Receptor Ca super(2+) Release Channels: molecular mechanism and isoform selectivity by Zhao, F, Li, P, Chen, SRW, Louis, C F, Fruen, B R

“…As an inhibitor of Ca super(2+) release through ryanodine receptor (RYR) channels, the skeletal muscle relaxant dantrolene has proven to be both a valuable…”
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