Search Results - "FROEYEN, Mathy"

Synthesis and evaluation of isothiazolo[4,5- b ]pyridines as cyclin G-associated kinase (GAK) inhibitors by Ivanova, Yulia, Spittaels, Sander, Gao, Ling-Jie, Schols, Dominique, Van Meervelt, Luc, Froeyen, Mathy, Dehaen, Wim, De Jonghe, Steven

“…Isothiazolo[4,3- ]pyridines have been extensively explored as inhibitors of cyclin G-associated kinase (GAK). In order to expand the structure-activity…”
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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral by Delang, Leen, Segura Guerrero, Nidya, Tas, Ali, Quérat, Gilles, Pastorino, Boris, Froeyen, Mathy, Dallmeier, Kai, Jochmans, Dirk, Herdewijn, Piet, Bello, Felio, Snijder, Eric J, de Lamballerie, Xavier, Martina, Byron, Neyts, Johan, van Hemert, Martijn J, Leyssen, Pieter

“…T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This…”
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Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems by Efthymiou, Tim, Gavette, Jesse, Stoop, Matthias, De Riccardis, Francesco, Froeyen, Mathy, Herdewijn, Piet, Krishnamurthy, Ramanarayanan

“…The paradigm of homogenous‐sugar‐backbone of RNA and DNA has reliably guided the construction of many functional and useful xeno nucleic acid (XNA) systems to…”
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Synthesis of a 3,7-Disubstituted Isothiazolo[4,3- b ]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase by Grisez, Tom, Ravi, Nitha Panikkassery, Froeyen, Mathy, Schols, Dominique, Van Meervelt, Luc, De Jonghe, Steven, Dehaen, Wim

“…Disubstituted isothiazolo[4,3- ]pyridines are known inhibitors of cyclin G-associated kinase. Since 3-substituted-7-aryl-isothiazolo[4,3- ]pyridines remain…”
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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase by Abdelnabi, Rana, Morais, Ana Theresa Silveira de, Leyssen, Pieter, Imbert, Isabelle, Beaucourt, Stéphanie, Blanc, Hervé, Froeyen, Mathy, Vignuzzi, Marco, Canard, Bruno, Neyts, Johan, Delang, Leen

“…Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits…”
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Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication by DELANG, Leen, VLIEGEN, Inge, FROEYEN, Mathy, NEYTS, Johan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins by Vanmeert, Michiel, Razzokov, Jamoliddin, Mirza, Muhammad Usman, Weeks, Stephen D, Schepers, Guy, Bogaerts, Annemie, Rozenski, Jef, Froeyen, Mathy, Herdewijn, Piet, Pinheiro, Vitor B, Lescrinier, Eveline

“…Xenobiotic nucleic acids (XNA) are nucleic acid analogues not present in nature that can be used for the storage of genetic information. In vivo XNA…”
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Frontispiece: Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems by Efthymiou, Tim, Gavette, Jesse, Stoop, Matthias, De Riccardis, Francesco, Froeyen, Mathy, Herdewijn, Piet, Krishnamurthy, Ramanarayanan

“…Construction of xeno nucleic acids (XNAs) has relied on RNA and DNA as models and, therefore, they contain strictly homogenous backbone repeat units with any…”
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Binary Genetic Cassettes for Selecting XNA-Templated DNA Synthesis In Vivo by Pezo, Valérie, Liu, Feng Wu, Abramov, Mikhail, Froeyen, Mathy, Herdewijn, Piet, Marlière, Philippe

“…Hereditary information, coded in two bases, can be conveyed to DNA in vivo in the form of cyclohexenyl nucleic acid (CeNA), arabinofuranosyl nucleic acid…”
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Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase by Musiu, Simone, Castillo, Yunierkis Perez, Muigg, Alexandra, Pürstinger, Gerhard, Leyssen, Pieter, Froeyen, Mathy, Neyts, Johan, Paeshuyse, Jan

“…The bovine viral diarrhea virus (BVDV), a pestivirus from the family of is ubiquitous and causes a range of clinical manifestations in livestock, mainly…”
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1′,5′-Anhydro‑l-ribo-hexitol Adenine Nucleic Acids (α‑l‑HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World by D’Alonzo, Daniele, Froeyen, Mathy, Schepers, Guy, Di Fabio, Giovanni, Van Aerschot, Arthur, Herdewijn, Piet, Palumbo, Giovanni, Guaragna, Annalisa

“…The synthesis and a preliminary investigation of the base pairing properties of (6′ → 4′)-linked 1′,5′-anhydro-l-ribo-hexitol nucleic acids (α-l-HNA) have…”
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A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro by KAPTEIN, Suzanne J. F, DE BURGHGRAEVE, Tine, GAMARNIK, Andrea V, SZTARICSKAI, Ferenc, NEYTS, Johan, FROEYEN, Mathy, PASTORINO, Boris, ALEN, Marijke M. F, MONDOTTE, Juan A, HERDEWIJN, Piet, JACOBS, Michael, DE LAMBALLERIE, Xavier, SCHOLS, Dominique

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase by Jian, Yanlin, Risseeuw, Martijn D. P., Froeyen, Mathy, Song, Lijun, Cappoen, Davie, Cos, Paul, Munier-Lehmann, Hélène, van Calenbergh, Serge

“…A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK)…”
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Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d by Guillaume, Joren, Wang, Jing, Janssens, Jonas, Remesh, Soumya G., Risseeuw, Martijn D. P., Decruy, Tine, Froeyen, Mathy, Elewaut, Dirk, Zajonc, Dirk M., Calenbergh, Serge Van

“…Invariant Natural Killer T-cells ( i NKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a…”
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N-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids by Vondenhoff, Gaston H, Pugach, Ksenia, Gadakh, Bharat, Carlier, Laurence, Rozenski, Jef, Froeyen, Mathy, Severinov, Konstantin, Van Aerschot, Arthur

“…Microcin C analogues were recently envisaged as important compounds for the development of novel antibiotics. Two issues that may pose problems to these…”
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Hybridisation potential of 1',3'-Di-O-methylaltropyranoside nucleic acids by Venkatesham, Akkaladevi, Kachare, Dhuldeo, Schepers, Guy, Rozenski, Jef, Froeyen, Mathy, Van Aerschot, Arthur

“…In further study of our series of six-membered ring-containing nucleic acids, different 1',3'-di-O-methyl altropyranoside nucleoside analogs (DMANA) were…”
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Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species by Lanko, Kristina, Sun, Liang, Froeyen, Mathy, Leyssen, Pieter, Delang, Leen, Mirabelli, Carmen, Neyts, Johan

“…Vapendavir is a rhino/enterovirus inhibitor that targets a hydrophobic pocket in the viral capsid preventing the virus from entering the cell. We set out to…”
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The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication by Tijsma, Aloys, Franco, David, Tucker, Simon, Hilgenfeld, Rolf, Froeyen, Mathy, Leyssen, Pieter, Neyts, Johan

“…Antivirals against enterovirus 71 (EV71) are urgently needed. We demonstrate that the novel enteroviral protease inhibitor (PI) SG85 and capsid binder (CB)…”
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Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline by Rihon, Jérôme, Mattelaer, Charles-Alexandre, Montalvão, Rinaldo Wander, Froeyen, Mathy, Pinheiro, Vitor Bernardes, Lescrinier, Eveline

“…The field of synthetic nucleic acids with novel backbone structures [xenobiotic nucleic acids (XNAs)] has flourished due to the increased importance of XNA…”
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Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA) by Luo, Min, Groaz, Elisabetta, Froeyen, Mathy, Pezo, Valérie, Jaziri, Faten, Leonczak, Piotr, Schepers, Guy, Rozenski, Jef, Marlière, Philippe, Herdewijn, Piet

“…A synthetic orthogonal polymer embracing a chiral acyclic-phosphonate backbone [(S)-ZNA] is presented that uniquely adds to the emerging family of xenobiotic…”
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