Search Results - "FRIGOLA, Jordi"

Stabilisation of half MCM ring by Cdt1 during DNA insertion by Guerrero-Puigdevall, Marina, Fernandez-Fuentes, Narcis, Frigola, Jordi

“…Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM)…”
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Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase by Coster, Gideon, Frigola, Jordi, Beuron, Fabienne, Morris, Edward P., Diffley, John F.X.

“…Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for…”
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Cdt1 stabilizes an open MCM ring for helicase loading by Frigola, Jordi, He, Jun, Kinkelin, Kerstin, Pye, Valerie E., Renault, Ludovic, Douglas, Max E., Remus, Dirk, Cherepanov, Peter, Costa, Alessandro, Diffley, John F. X.

“…ORC, Cdc6 and Cdt1 act together to load hexameric MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replication origins. Here we…”
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Activation of the replicative DNA helicase: breaking up is hard to do by Boos, Dominik, Frigola, Jordi, Diffley, John FX

“…The precise duplication of the eukaryotic genome is accomplished by carefully coordinating the loading and activation of the replicative DNA helicase so that…”
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Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer by Frigola, Jordi, Solé, Xavier, Paz, Maria F., Moreno, Victor, Esteller, Manel, Capellà, Gabriel, Peinado, Miguel A.

“…Cancer cells are characterized by a generalized disruption of the DNA methylation pattern involving an overall decrease in the level of 5-methylcytosine…”
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Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy by FRIGOLA, Jordi, MUNOZ, Mar, CLARK, Susan J, MORENO, Victor, CAPELLA, Gabriel, PEINADO, Miguel A

“…Inactivation of specific tumor suppressor genes by transcriptional silencing associated with hypermethylation of the promoter is a common event in cancer. We…”
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Analysis of DNA methylation by amplification of intermethylated sites (AIMS) by Jordà, Mireia, Rodríguez, Jairo, Frigola, Jordi, Peinado, Miguel A

“…DNA methylation is an epigenetic modification that plays a crucial role in the control of gene expression and chromosome structure in plants and mammalian…”
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1,2-Diaryl(3-pyridyl)ethanone oximes. Intermolecular hydrogen bonding networks revealed by X-ray diffraction by Alcalde, Ermitas, Mesquida, Neus, Alvarez-Rúa, Carmen, Cuberes, Rosa, Frigola, Jordi, García-Granda, Santiago

“…The synthesis of a set of 1-aryl-2-aryl(3-pyridyl)ethanones 1-5 and the corresponding ketoximes 6-9 is reported. Structural studies of oximes 6, 7 and 9 were…”
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ATPase-dependent quality control of DNA replication origin licensing by Frigola, Jordi, Remus, Dirk, Mehanna, Amina, Diffley, John F. X.

“…The regulated loading of the Mcm2–7 DNA helicase (comprising six related subunits, Mcm2 to Mcm7) into pre-replicative complexes at multiple replication origins…”
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AUDIO DEVICES by Munoz, Jordi Frigola

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Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers by RODRIGUEZ, Jairo, FRIGOLA, Jordi, PEINADO, Miguel A, VENDRELL, Elisenda, RISQUES, Rosa-Ana, FRAGA, Mario F, MORALES, Cristina, MORENO, Victor, ESTELLER, Manel, CAPELLA, Gabriel, RIBAS, Maria

“…DNA hypomethylation is a common trait of colorectal cancer. Studies in tumor cell lines and animal models indicate that genome-wide demethylation may cause…”
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Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band by Clark, Susan J, Frigola, Jordi, Song, Jenny, Stirzaker, Clare, Hinshelwood, Rebecca A, Peinado, Miguel A

“…We report a new mechanism in carcinogenesis involving coordinate long-range epigenetic gene silencing. Epigenetic silencing in cancer has always been envisaged…”
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Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT6 receptor ligands by Alcalde, Ermitas, Mesquida, Neus, Frigola, Jordi, López-Pérez, Sara, Mercè, Ramon

“…A series of novel indene derivatives designed by a scaffold selection gave access to several examples of (Z)-arylmethylideneindenes and indenylsulfonamides…”
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ATPase-dependent quality control of DNA replication origin licensing by Frigola, Jordi, Remus, Dirk, Mehanna, Amina, Diffley, John F.X

“…The regulated loading of the Mcm2-7 DNA helicase (comprising six related subunits, Mcm2 to Mcm7) into pre-replicative complexes at multiple replication origins…”
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Indene-Based Scaffolds. 2. An Indole−Indene Switch: Discovery of Novel Indenylsulfonamides as 5-HT6 Serotonin Receptor Agonists by Alcalde, Ermitas, Mesquida, Neus, López-Pérez, Sara, Frigola, Jordi, Mercè, Ramon

“…Scaffold selection involving an indole-to-indene core change led to the discovery of a series of indenylsulfonamides that act as 5-HT6 serotonin receptor…”
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Heterocyclic Betaines. XXII. Azinium(Azolium) 4-Nitrobenzimidazolate Inner Salts and Their Derivatives with Several Interannular Spacers. Synthesis, Characterization and Antitrichomonal Activity by ALCALDE, Ermitas, PEREZ-GARCIA, Lluisa, DINARES, Immaculada, FRIGOLA, Jordi

“…The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate bentaines and their derivatives with several interannular linkages has been…”
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Synthesis and Structure-Activity Relationships of a New Series of Benzimidazoles as H1-Antihistaminic Agents by CUBERES, Maria Rosa, CONTIJOCH, Montserrat, CALVET, Carme, ALEGRE, Julia, QUINTANA, Jordi Ramon, FRIGOLA, Jordi

“…New 2-(4-(4-azolybutyl)piperazinyl)-, 2-(4-(4-azolybutyl)piperazinylmethyl)-, 2-(4-(4-azolylbutyl)homopiperazinyl)- and…”
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Heterocyclic Betaines. XVI. Properties of (E)-1-Alkyl(or Aminoalkyl)-4-(2-(1H-benzimidazol-2-yl)vinyl)pyridinium Salts by ALCALDE, Ermitas, PEREZ-GARCIA, Lluisa, FRIGOLA, Jordi

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Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS) by Frigola, Jordi, Ribas, Maria, Risques, Rosa-Ana, Peinado, Miguel A.

“…Alterations of the DNA methylation pattern have been related to generalized chromosomal disruption and inactivation of multiple tumor suppressor genes in…”
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Indene-based frameworks targeting the 5-HT6 serotonin receptor: Ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts by ALCALDE, Ermitas, MESQUIDA, Neus, LOPEZ-PEREZ, Sara, FRIGOLA, Jordi, MERCE, Ramon, HOLENZ, Jörg, PUJOL, Marta, HERNANDEZ, Enrique

“…Further studies in quest of 5-HT(6) serotonin receptor ligands led to the design and synthesis of a few selected examples of N-(inden-5-yl)sulfonamides with a…”
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