Search Results - "FRIEND, Stephen H"

Crowdsourcing biomedical research: leveraging communities as innovation engines by Saez-Rodriguez, Julio, Costello, James C., Friend, Stephen H., Kellen, Michael R., Mangravite, Lara, Meyer, Pablo, Norman, Thea, Stolovitzky, Gustavo

“…Key Points Crowdsourcing is emerging as a novel framework to tackle scientific problems. A variant of crowdsourcing, scientific competitions known as…”
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The Use of Smartphones for Health Research by Dorsey, E. Ray, “Yvonne” Chan, Yu-Feng, McConnell, Michael V., Shaw, Stanley Y., Trister, Andrew D., Friend, Stephen H.

“…Because of their growing popularity and functionality, smartphones are increasingly valuable potential tools for health and medical research. Using…”
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The mPower study, Parkinson disease mobile data collected using ResearchKit by Bot, Brian M., Suver, Christine, Neto, Elias Chaibub, Kellen, Michael, Klein, Arno, Bare, Christopher, Doerr, Megan, Pratap, Abhishek, Wilbanks, John, Dorsey, E. Ray, Friend, Stephen H., Trister, Andrew D.

“…Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide…”
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Clues from the resilient by Friend, Stephen H, Schadt, Eric E

“…Genetic information from individuals who do not succumb to disease may point to new therapies and ideas about wellness The genetics approach to uncovering the…”
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Potential of the Synthetic Lethality Principle by Nijman, Sebastian M. B., Friend, Stephen H.

“…Elucidating the first principles of synthetic lethality in cancer, including biological context, will assist clinical translation. Most cancer mutations,…”
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App-enabled trial participation: Tectonic shift or tepid rumble? by Friend, Stephen H

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Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection by Lee, Anna Y, Ewing, Adam D, Ellrott, Kyle, Hu, Yin, Houlahan, Kathleen E, Bare, J Christopher, Espiritu, Shadrielle Melijah G, Huang, Vincent, Dang, Kristen, Chong, Zechen, Caloian, Cristian, Yamaguchi, Takafumi N, Kellen, Michael R, Chen, Ken, Norman, Thea C, Friend, Stephen H, Guinney, Justin, Stolovitzky, Gustavo, Haussler, David, Margolin, Adam A, Stuart, Joshua M, Boutros, Paul C

“…The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and…”
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Improving breast cancer survival analysis through competition-based multidimensional modeling by Bilal, Erhan, Dutkowski, Janusz, Guinney, Justin, Jang, In Sock, Logsdon, Benjamin A, Pandey, Gaurav, Sauerwine, Benjamin A, Shimoni, Yishai, Moen Vollan, Hans Kristian, Mecham, Brigham H, Rueda, Oscar M, Tost, Jorg, Curtis, Christina, Alvarez, Mariano J, Kristensen, Vessela N, Aparicio, Samuel, Børresen-Dale, Anne-Lise, Caldas, Carlos, Califano, Andrea, Friend, Stephen H, Ideker, Trey, Schadt, Eric E, Stolovitzky, Gustavo A, Margolin, Adam A

“…Breast cancer is the most common malignancy in women and is responsible for hundreds of thousands of deaths annually. As with most cancers, it is a…”
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Value of Engagement in Digital Health Technology Research: Evidence Across 6 Unique Cohort Studies by Goodday, Sarah M, Karlin, Emma, Brooks, Alexa, Chapman, Carol, Harry, Christiana, Lugo, Nelly, Peabody, Shannon, Rangwala, Shazia, Swanson, Ella, Tempero, Jonell, Yang, Robin, Karlin, Daniel R, Rabinowicz, Ron, Malkin, David, Travis, Simon, Walsh, Alissa, Hirten, Robert P, Sands, Bruce E, Bettegowda, Chetan, Holdhoff, Matthias, Wollett, Jessica, Szajna, Kelly, Dirmeyer, Kallan, Dodd, Anna, Hutchinson, Shawn, Ramotar, Stephanie, Grant, Robert C, Boch, Adrien, Wildman, Mackenzie, Friend, Stephen H

“…Wearable digital health technologies and mobile apps (personal digital health technologies [DHTs]) hold great promise for transforming health research and…”
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Detecting the impact of subject characteristics on machine learning-based diagnostic applications by Chaibub Neto, Elias, Pratap, Abhishek, Perumal, Thanneer M., Tummalacherla, Meghasyam, Snyder, Phil, Bot, Brian M., Trister, Andrew D., Friend, Stephen H., Mangravite, Lara, Omberg, Larsson

“…Collection of high-dimensional, longitudinal digital health data has the potential to support a wide-variety of research and clinical applications including…”
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Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer by Margolin, Adam A, Bilal, Erhan, Huang, Erich, Norman, Thea C, Ottestad, Lars, Mecham, Brigham H, Sauerwine, Ben, Kellen, Michael R, Mangravite, Lara M, Furia, Matthew D, Vollan, Hans Kristian Moen, Rueda, Oscar M, Guinney, Justin, Deflaux, Nicole A, Hoff, Bruce, Schildwachter, Xavier, Russnes, Hege G, Park, Daehoon, Vang, Veronica O, Pirtle, Tyler, Youseff, Lamia, Citro, Craig, Curtis, Christina, Kristensen, Vessela N, Hellerstein, Joseph, Friend, Stephen H, Stolovitzky, Gustavo, Aparicio, Samuel, Caldas, Carlos, Børresen-Dale, Anne-Lise

“…Although molecular prognostics in breast cancer are among the most successful examples of translating genomic analysis to clinical applications, optimal…”
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How molecular profiling could revolutionize drug discovery by Stoughton, Roland B, Friend, Stephen H

“…Information from genomic, proteomic and metabolomic measurements has already benefited target discovery and validation, assessment of efficacy and toxicity of…”
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The cancer predisposition revolution by Malkin, David, Garber, Judy E., Strong, Louise C., Friend, Stephen H.

“…How was the inherited basis of cancer foreshadowed? Studies of rare cancer predisposition syndromes often lead to the identification of genes critical to…”
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Gene expression profiling predicts clinical outcome of breast cancer by Friend, Stephen H, van 't Veer, Laura J, Dai, Hongyue, van de Vijver, Marc J, He, Yudong D, Hart, Augustinus A. M, Mao, Mao, Peterse, Hans L, van der Kooy, Karin, Marton, Matthew J, Witteveen, Anke T, Schreiber, George J, Kerkhoven, Ron M, Roberts, Chris, Linsley, Peter S, Bernards, René

“…Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for…”
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Genetics of gene expression surveyed in maize, mouse and man by Schadt, Eric E, Friend, Stephen H, Monks, Stephanie A, Drake, Thomas A, Lusis, Aldons J, Che, Nam, Colinayo, Veronica, Ruff, Thomas G, Milligan, Stephen B, Lamb, John R, Cavet, Guy, Linsley, Peter S, Mao, Mao, Stoughton, Roland B

“…Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in…”
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Predictive, personalized, preventive, participatory (P4) cancer medicine by Hood, Leroy, Friend, Stephen H

“…The authors takes a systems-biology approach to the problems of personalized cancer medicine. They describe the challenges of moving to a discipline that is…”
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Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions by Bartz, Steven R., Zhang, Zhan, Burchard, Julja, Imakura, Maki, Martin, Melissa, Palmieri, Anthony, Needham, Rachel, Guo, Jie, Gordon, Marcia, Chung, Namjin, Warrener, Paul, Jackson, Aimee L., Carleton, Michael, Oatley, Melissa, Locco, Louis, Santini, Francesca, Smith, Todd, Kunapuli, Priya, Ferrer, Marc, Strulovici, Berta, Friend, Stephen H., Linsley, Peter S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Leveraging crowdsourcing to facilitate the discovery of new medicines by Norman, Thea C, Bountra, Chas, Edwards, Aled M, Yamamoto, Keith R, Friend, Stephen H

“…Gloomy predictions about the future of pharma have forced the industry to investigate alternative models of drug discovery. Public-private partnerships (PPPs)…”
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Toxicogenomics and drug discovery: will new technologies help us produce better drugs? by Ulrich, Roger, Friend, Stephen H

“…Acting on reports in the late 1980s that most drug candidates fail in development, pharmaceutical discovery programmes responded by devising ways to increase…”
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Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles by Roberts, Christopher J., Nelson, Bryce, Marton, Matthew J., Stoughton, Roland, Meyer, Michael R., Bennett, Holly A., He, Yudong D., Dai, Hongyue, Walker, Wynn L., Hughes, Timothy R., Tyers, Mike, Boone, Charles, Friend, Stephen H.

“…Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in…”
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