Search Results - "FRIEDBERG, C"

How nucleotide excision repair protects against cancer by Friedberg, Errol C

“…Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type--nucleotide excision repair (NER)--specifically…”
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DNA damage and repair by Friedberg, Errol C

“…The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state…”
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Suffering in silence: the tolerance of DNA damage by Friedberg, Errol C

“…When cells that are actively replicating DNA encounter sites of base damage or strand breaks, replication might stall or arrest. In this situation, cells rely…”
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International Organization for Standardization (ISO) 15189 by Schneider, Frank, Maurer, Caroline, Friedberg, Richard C

“…The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international…”
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A brief history of the DNA repair field by Friedberg, Errol C

“…The history of the repair of damaged DNA can be traced to the mid-1930s. Since then multiple DNA repair mechanisms, as well as other biological responses to…”
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Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations by Friedberg, Errol C., Wagner, Robert, Radman, Miroslav

“…Cell death caused by arrested replication of damaged or structurally altered DNA can be avoided in prokaryotic and eukaryotic cells by multiple DNA polymerases…”
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Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals by Shachar, Sigal, Ziv, Omer, Avkin, Sharon, Adar, Sheera, Wittschieben, John, Reißner, Thomas, Chaney, Stephen, Friedberg, Errol C, Wang, Zhigang, Carell, Thomas, Geacintov, Nicholas, Livneh, Zvi

“…DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect…”
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Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis? by Friedberg, Errol C., Lehmann, Alan R., Fuchs, Robert P.P.

“…The replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechanism for relieving arrested DNA replication. The process…”
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Autoimmune hemolytic anemia by Gehrs, Bradley C., Friedberg, Richard C.

“…Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the…”
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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes by Dragileva, Ella, Hendricks, Audrey, Teed, Allison, Gillis, Tammy, Lopez, Edith T, Friedberg, Errol C, Kucherlapati, Raju, Edelmann, Winfried, Lunetta, Kathryn L, MacDonald, Marcy E, Wheeler, Vanessa C

“…Abstract Modifying the length of the Huntington's disease (HD) CAG repeat, the major determinant of age of disease onset, is an attractive therapeutic…”
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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis by Guo, Caixia, Fischhaber, Paula L., Luk-Paszyc, Margaret J., Masuda, Yuji, Zhou, Jing, Kamiya, Kenji, Kisker, Caroline, Friedberg, Errol C.

“…Polκ and Rev1 are members of the Y family of DNA polymerases involved in tolerance to DNA damage by replicative bypass [translesion DNA synthesis (TLS)]. We…”
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Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7 by Friedberg, Errol C., Meira, Lisiane B.

“…We present Version 7 of a database of mouse mutant strains that affect biological responses to DNA damage. This database is also electronically available at…”
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The Many Faces of DNA Polymerases: Strategies for Mutagenesis and for Mutational Avoidance by Friedberg, Errol C., Feaver, William J., Gerlach, Valerie L.

“…A current working hypothesis is that when highly processive semiconservative DNA replication is arrested at lesions in DNA, the replicative machinery is…”
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Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation by Lv, Lingna, Wang, Fengli, Ma, Xiaolu, Yang, Yeran, Wang, Zhifeng, Liu, Hongmei, Li, Xiaoling, Liu, Zhenbo, Zhang, Ting, Huang, Min, Friedberg, Errol C, Tang, Tie-Shan, Guo, Caixia

“…Translesion DNA synthesis (TLS) can use specialized DNA polymerases to insert and/or extend nucleotides across lesions, thereby limiting stalled replication…”
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Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome by van der Pluijm, Ingrid, Garinis, George A, Brandt, Renata M C, Gorgels, Theo G M F, Wijnhoven, Susan W, Diderich, Karin E M, de Wit, Jan, Mitchell, James R, van Oostrom, Conny, Beems, Rudolf, Niedernhofer, Laura J, Velasco, Susana, Friedberg, Errol C, Tanaka, Kiyoji, van Steeg, Harry, Hoeijmakers, Jan H J, van der Horst, Gijsbertus T J

“…Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria that is caused by a defect in the transcription-coupled repair…”
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The role of endogenous and exogenous DNA damage and mutagenesis by Friedberg, Errol C, McDaniel, Lisa D, Schultz, Roger A

“…The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and…”
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DNA repair: From molecular mechanism to human disease by Friedberg, Errol C., Aguilera, Andres, Gellert, Martin, Hanawalt, Philip C., Hays, John B., Lehmann, Alan R., Lindahl, Tomas, Lowndes, Noel, Sarasin, Alain, Wood, Richard D.

“…A comprehensive meeting on biological responses to DNA damage organized by Alan Lehmann, Deborah Barnes, Wouter Ferro, Robert Fuchs, Jan Hoeijmakers, Roland…”
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Deletion of XPC Leads to Lung Tumors in Mice and Is Associated with Early Events in Human Lung Carcinogenesis by Hollander, M. Christine, Philburn, Robyn T., Patterson, Andrew D., Velasco-Miguel, Susana, Friedberg, Errol C., Linnoila, R. Ilona, Fornace, Albert J., Setlow, Richard B.

“…Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been…”
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Increased dietary cholesterol promotes enhanced mutagenesis in DNA polymerase kappa-deficient mice by Singer, William D., Osimiri, Lindsey C., Friedberg, Errol C.

“…•Mutation frequency of DNA increased in apoE−/−Polk−/− mouse organs after high cholesterol diet.•The high cholesterol diet had no effect on mutation frequency…”
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The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair by Russell, S J, Reed, S H, Huang, W, Friedberg, E C, Johnston, S A

“…The 26S proteasome degrades proteins targeted by the ubiquitin pathway, a function thought to explain its role in cellular processes. The proteasome interacts…”
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