Search Results - "FRIEBE, Matthias"

Specific PET Imaging of xC― Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism by KOGLIN, Norman, MUELLER, Andre, BERNDT, Mathias, SCHMITT-WILLICH, Heribert, TOSCHI, Luisella, STEPHENS, Andrew W, GEKELER, Volker, FRIEBE, Matthias, DINKELBORG, Ludger M

“…(18)F-labeled small molecules targeting adaptations of tumor metabolism possess the potential for early tumor detection with high sensitivity and specificity…”
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Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies by Mittra, Erik S, Koglin, Norman, Mosci, Camila, Kumar, Meena, Hoehne, Aileen, Keu, Khun Visith, Iagaru, Andrei H, Mueller, Andre, Berndt, Mathias, Bullich, Santiago, Friebe, Matthias, Schmitt-Willich, Heribert, Gekeler, Volker, Fels, Lüder M, Bacher-Stier, Claudia, Moon, Dae Hyuk, Chin, Frederick T, Stephens, Andrew W, Dinkelborg, Ludger M, Gambhir, Sanjiv S

“…(S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a novel radiopharmaceutical for Positron Emission Tomography (PET) imaging. It is a glutamate…”
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Radioimmunotherapy of Solid Tumors by Targeting Extra Domain B Fibronectin: Identification of the Best-Suited Radioimmunoconjugate by BERNDORFF, Dietmar, BORKOWSKI, Sandra, SIEGER, Stephanie, ROTHER, Axel, FRIEBE, Matthias, VITI, Francesca, HILGER, Christoph S, CYR, John E, DINKELBORG, Ludger M

“…Purpose: The expression of extra domain B (ED-B) fibronectin is always associated with angiogenic processes and can be exclusively observed in tissues…”
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Preclinical Evaluation of an 131I-Labeled Benzamide for Targeted Radiotherapy of Metastatic Melanoma by JOYAL, John L, BARRETT, John A, FRIEBE, Matthias, DINKELBORG, Ludger, STUBBS, James B, STABIN, Michael G, MAIRS, Rob, POMPER, Martin G, BABICH, John W, MARQUIS, John C, JIANQING CHEN, HILLER, Shawn M, MARESCA, Kevin P, BOYD, Marie, GAGE, Kenneth, NIMMAGADDA, Sridhar, KRONAUGE, James F

“…Radiolabeled benzamides are attractive candidates for targeted radiotherapy of metastatic melanoma as they bind melanin and exhibit high tumor uptake and…”
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Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer by Sah, Bert-Ram, Burger, Irene A, Schibli, Roger, Friebe, Matthias, Dinkelborg, Ludger, Graham, Keith, Borkowski, Sandra, Bacher-Stier, Claudia, Valencia, Ray, Srinivasan, Ananth, Hany, Thomas F, Mu, Linjing, Wild, Peter J, Schaefer, Niklaus G

“…The aim of this first-in-man study was to demonstrate the feasibility, safety, and tolerability, as well as provide dosimetric data and evaluate the imaging…”
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Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin by Rossin, Raffaella, Berndorff, Dietmar, Friebe, Matthias, Dinkelborg, Ludger M, Welch, Michael J

“…The aim of this study was to image the extra domain B (ED-B) of fibronectin, an angiogenesis-related target, in solid tumors using small-animal PET. Toward…”
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Application of locked nucleic acids to improve aptamer in vivo stability and targeting function by Schmidt, Kathrin S., Borkowski, Sandra, Kurreck, Jens, Stephens, Andrew W., Bald, Rolf, Hecht, Maren, Friebe, Matthias, Dinkelborg, Ludger, Erdmann, Volker A.

“…Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor…”
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sup 18^F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi by Lohrke, Jessica, Siebeneicher, Holger, Berger, Markus, Reinhardt, Michael, Berndt, Mathias, Mueller, Andre, Zerna, Marion, Koglin, Norman, Oden, Felix, Bauser, Marcus, Friebe, Matthias, Dinkelborg, Ludger M, Huetter, Joachim, Stephens, Andrew W

“…Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks, and pulmonary embolism are major causes of morbidity and mortality…”
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18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi by Lohrke, Jessica, Siebeneicher, Holger, Berger, Markus, Reinhardt, Michael, Berndt, Mathias, Mueller, Andre, Zerna, Marion, Koglin, Norman, Oden, Felix, Bauser, Marcus, Friebe, Matthias, Dinkelborg, Ludger M, Huetter, Joachim, Stephens, Andrew W

“…Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks, and pulmonary embolism are major causes of morbidity and mortality…”
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4-[18F]Fluoroglutamic Acid (BAY 85-8050), a New Amino Acid Radiotracer for PET Imaging of Tumors: Synthesis and in Vitro Characterization by Krasikova, Raisa N, Kuznetsova, Olga F, Fedorova, Olga S, Belokon, Yuri N, Maleev, Viktor I, Mu, Linjing, Ametamey, Simon, Schubiger, P. August, Friebe, Matthias, Berndt, Mathias, Koglin, Norman, Mueller, Andre, Graham, Keith, Lehmann, Lutz, Dinkelborg, Ludger M

“…There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic…”
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Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system by Franck, Dominic, Kniess, Torsten, Steinbach, Jörg, Zitzmann-Kolbe, Sabine, Friebe, Matthias, Dinkelborg, Ludger M., Graham, Keith

“…The [18F]fluorocyclobutyl group has the potential to be a metabolically stable prosthetic group for PET tracers. The synthesis of the radiolabeling precursor…”
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First clinical results of (D)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in patients with non-small cell lung cancer and head and neck squamous cell carcinoma by Burger, Irene A, Zitzmann-Kolbe, Sabine, Pruim, Jan, Friebe, Matthias, Graham, Keith, Stephens, Andrew, Dinkelborg, Ludger, Kowal, Kristin, Schibli, Roger, Luurtsema, Gert, Maas, Bram, Horn-Tutic, Michaela, Haerle, Stephan K, Wiegers, Johan, Schaefer, Niklaus G, Hany, Thomas F, von Schulthess, Gustav K

“…(D)-(18)F-fluoromethyltyrosine (d-(18)F-FMT), or BAY 86-9596, is a novel (18)F-labeled tyrosine derivative rapidly transported by the l-amino acid transporter…”
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Novel Chemically Modified Analogues of Neuropeptide Y for Tumor Targeting by Zwanziger, Denise, Khan, Irfan Ullah, Neundorf, Ines, Sieger, Stephanie, Lehmann, Lutz, Friebe, Matthias, Dinkelborg, Ludger, Beck-Sickinger, Annette G

“…The successful use of peptides as potential radiopharmaceuticals essentially requires the modification of the bioactive peptide hormones to introduce chelators…”
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Dosimetry and First Clinical Evaluation of the New ^sup 18^F-Radiolabeled Bombesin Analogue BAY 864367 in Patients with Prostate Cancer by Sah, Bert-Ram, Burger, Irene A, Schibli, Roger, Friebe, Matthias, Dinkelborg, Ludger, Graham, Keith, Borkowski, Sandra, Bacher-Stier, Claudia, Valencia, Ray, Srinivasan, Ananth, Hany, Thomas F, Mu, Linjing, Wild, Peter J, Schaefer, Niklaus G

“…The aim of this first-in-man study was to demonstrate the feasibility, safety, and tolerability, as well as provide dosimetric data and evaluate the imaging…”
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Dosimetry and First Clinical Evaluation of the New 18 F-Radiolabeled Bombesin Analogue BAY 864367 in Patients with Prostate Cancer by Sah, Bert-Ram, Burger, Irene A., Schibli, Roger, Friebe, Matthias, Dinkelborg, Ludger, Graham, Keith, Borkowski, Sandra, Bacher-Stier, Claudia, Valencia, Ray, Srinivasan, Ananth, Hany, Thomas F., Mu, Linjing, Wild, Peter J., Schaefer, Niklaus G.

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Dosimetry and First Clinical Evaluation of the New super(18)F-Radiolabeled Bombesin Analogue BAY 864367 in Patients with Prostate Cancer by Sah, Bert-Ram, Burger, Irene A, Schibli, Roger, Friebe, Matthias, Dinkelborg, Ludger, Graham, Keith, Borkowski, Sandra, Bacher-Stier, Claudia, Valencia, Ray, Srinivasan, Ananth, Hany, Thomas F, Mu, Linjing, Wild, Peter J, Schaefer, Niklaus G

“…The aim of this first-in-man study was to demonstrate the feasibility, safety, and tolerability, as well as provide dosimetric data and evaluate the imaging…”
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Pilot Preclinical and Clinical Evaluation of by Mittra, Erik S, Koglin, Norman, Mosci, Camila, Kumar, Meena, Hoehne, Aileen, Keu, Khun Visith, Iagaru, Andrei H, Mueller, Andre, Berndt, Mathias, Bullich, Santiago, Friebe, Matthias, Schmitt-Willich, Heribert, Gekeler, Volker, Fels, Lüder M, Bacher-Stier, Claudia, Moon, Dae Hyuk, Chin, Frederick T, Stephens, Andrew W, Dinkelborg, Ludger M, Gambhir, Sanjiv S

“…Purpose (S)-4-(3-[.sup.18 F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a novel radiopharmaceutical for Positron Emission Tomography (PET) imaging. It is a…”
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Pilot Preclinical and Clinical Evaluation of for PET/CT Imaging of Intracranial Malignancies by Mittra, Erik S, Koglin, Norman, Mosci, Camila, Kumar, Meena, Hoehne, Aileen, Keu, Khun Visith, Iagaru, Andrei H, Mueller, Andre, Berndt, Mathias, Bullich, Santiago, Friebe, Matthias, Schmitt-Willich, Heribert, Gekeler, Volker, Fels, Lüder M, Bacher-Stier, Claudia, Moon, Dae Hyuk, Chin, Frederick T, Stephens, Andrew W, Dinkelborg, Ludger M, Gambhir, Sanjiv S

“…Purpose (S)-4-(3-[.sup.18 F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a novel radiopharmaceutical for Positron Emission Tomography (PET) imaging. It is a…”
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Radiopharmaceutical Therapy of Patients with Metastasized Melanoma with the Melanin-Binding Benzamide sigma up 131 member of -BA52 by Mier, Walter, Kratochwil, Clemens, Hassel, Jessica C, Giesel, Frederik L, Beijer, Barbro, Babich, John W, Friebe, Matthias, Eisenhut, Michael, Enk, Alexander, Haberkorn, Uwe

“…The performance of cytotoxic drugs is defined by their selectivity of uptake and action in tumor tissue. Recent clinical responses achieved by treating…”
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Radiopharmaceutical Therapy of Patients with Metastasized Melanoma with the Melanin-Binding Benzamide ^sup 131^I-BA52 by Mier, Walter, Kratochwil, Clemens, Hassel, Jessica C, Giesel, Frederik L, Beijer, Barbro, Babich, John W, Friebe, Matthias, Eisenhut, Michael, Enk, Alexander, Haberkorn, Uwe

“…The performance of cytotoxic drugs is defined by their selectivity of uptake and action in tumor tissue. Recent clinical responses achieved by treating…”
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