Search Results - "FRIDMAN, Rafael"

Discoidin domain receptor tyrosine kinases: new players in cancer progression by Valiathan, Rajeshwari R., Marco, Marta, Leitinger, Birgit, Kleer, Celina G., Fridman, Rafael

“…Almost all human cancers display dysregulated expression and/or function of one or more receptor tyrosine kinases (RTKs). The strong causative association…”
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Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma by Ruggeri, Jeanine M., Franco-Barraza, Janusz, Sohail, Anjum, Zhang, Yaqing, Long, Daniel, Pasca di Magliano, Marina, Cukierman, Edna, Fridman, Rafael, Crawford, Howard C.

“…Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1…”
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DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome by Richter, Hans, Satz, Alexander L, Bedoucha, Marc, Buettelmann, Bernd, Petersen, Ann C, Harmeier, Anja, Hermosilla, Ricardo, Hochstrasser, Remo, Burger, Dominique, Gsell, Bernard, Gasser, Rodolfo, Huber, Sylwia, Hug, Melanie N, Kocer, Buelent, Kuhn, Bernd, Ritter, Martin, Rudolph, Markus G, Weibel, Franziska, Molina-David, Judith, Kim, Jin-Ju, Santos, Javier Varona, Stihle, Martine, Georges, Guy J, Bonfil, R. Daniel, Fridman, Rafael, Uhles, Sabine, Moll, Solange, Faul, Christian, Fornoni, Alessia, Prunotto, Marco

“…The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these…”
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Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection by Fridman, Rafael, Benton, Gabriel, Aranoutova, Irina, Kleinman, Hynda K, Bonfil, R Daniel

“…This protocol requires 2–4 h and presents a method for injecting tumor cells, cancer stem cells or dispersed biopsy material into subcutaneous or orthotopic…”
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Novel MMP-9 Substrates in Cancer Cells Revealed by a Label-free Quantitative Proteomics Approach by Xu, Danmei, Suenaga, Naoko, Edelmann, Mariola J., Fridman, Rafael, Muschel, Ruth J., Kessler, Benedikt M.

“…Matrix metalloproteinase-9 (MMP-9) is implicated in tumor metastasis as well as a variety of inflammatory and pathological processes. Although many substrates…”
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A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia by Gu, Zezong, Cui, Jiankun, Brown, Stephen, Fridman, Rafael, Mobashery, Shahriar, Strongin, Alex Y, Lipton, Stuart A

“…Neuronal cell death occurs during many neurodegenerative disorders and stroke. The aberrant, excessive activity of matrix metalloproteinases (MMPs), especially…”
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Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H‐Ras‐induced epithelial to mesenchymal transition by Koh, Minsoo, Woo, Yunjung, Valiathan, Rajeshwari R., Jung, Hae Yoen, Park, So Yeon, Kim, Yong Nyun, Kim, Hyeong‐Reh Choi, Fridman, Rafael, Moon, Aree

“…The epithelial‐to‐mesenchymal transition (EMT) process allows carcinoma cells to dissociate from the primary tumor thereby facilitating tumor cell invasion and…”
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Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein by Jung, Ki-Kyung, Liu, Xu-Wen, Chirco, Rosemarie, Fridman, Rafael, Kim, Hyeong-Reh Choi

“…This study identified CD63, a member of the tetraspanin family, as a TIMP‐1 interacting protein by yeast two‐hybrid screening. Immunoprecipitation and confocal…”
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Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP) by Osenkowski, Pamela, Toth, Marta, Fridman, Rafael

“…Matrix metalloproteinases (MMPs) are multidomain zinc‐dependent proteolytic enzymes that play pivotal roles in many normal and pathological processes. Some…”
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TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP by Bernardo, M Margarida, Fridman, Rafael

“…The matrix metalloproteinase (MMP)-2 has a crucial role in extracellular matrix degradation associated with cancer metastasis and angiogenesis. The latent…”
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Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness by Bonfil, R. Daniel, Chen, Wei, Vranic, Semir, Sohail, Anjum, Shi, Dongping, Jang, Hyejeong, Kim, Hyeong-Reh, Prunotto, Marco, Fridman, Rafael

“…Background The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to…”
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Galectin-3 Cleavage : A Novel Surrogate Marker for Matrix Metalloproteinase Activity in Growing Breast Cancers by NANGIA-MAKKER, Pratima, RAZ, Tirza, TAIT, Larry, HOGAN, Victor, FRIDMAN, Rafael, RAZ, Avraham

“…Failed therapies directed against matrix metalloproteinases (MMP) in cancer patients may be attributed, in part, to lack of diagnostic tools to differentiate…”
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Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome by Kim, Jin-Ju, David, Judith M., Wilbon, Sydney S., Santos, Javier V., Patel, Devang M., Ahmad, Anis, Mitrofanova, Alla, Liu, Xiaochen, Mallela, Shamroop K., Ducasa, Gloria M., Ge, Mengyuan, Sloan, Alexis J., Al-Ali, Hassan, Boulina, Marcia, Mendez, Armando J., Contreras, Gabriel N., Prunotto, Marco, Sohail, Anjum, Fridman, Rafael, Miner, Jeffrey H., Merscher, Sandra, Fornoni, Alessia

“…Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by collagens that is involved in the pathogenesis of fibrotic disorders…”
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Angiotensin‐converting enzyme inhibitors increase anti‐fibrotic biomarkers in African Americans with left ventricular hypertrophy by Romero, Cesar, Mathew, Shobi, Wasinski, Benjamin, Reed, Brian, Brody, Aaron, Dawood, Rachelle, Twiner, Michael J., McNaughton, Candace D., Fridman, Rafael, Flack, John M., Carretero, Oscar A., Levy, Phillip D.

“…Angiotensin‐converting enzyme inhibitors (ACEi) are part of the indicated treatment in hypertensive African Americans. ACEi have blood pressure‐independent…”
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Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration by SABBOTA, Aaron L, CHOI KIM, Hyeong-Reh, XIAONING ZHE, FRIDMAN, Rafael, BONFIL, R. Daniel, CHER, Michael L

“…Membrane type 1 matrix metalloproteinase (MT1-MMP) plays an essential role in protease-mediated extracellular matrix (ECM) degradation, but it also functions…”
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Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime by Moll, Solange, Yasui, Yukari, Abed, Ahmed, Murata, Takeshi, Shimada, Hideaki, Maeda, Akira, Fukushima, Naoshi, Kanamori, Masakazu, Uhles, Sabine, Badi, Laura, Cagarelli, Thomas, Formentini, Ivan, Drawnel, Faye, Georges, Guy, Bergauer, Tobias, Gasser, Rodolfo, Bonfil, R Daniel, Fridman, Rafael, Richter, Hans, Funk, Juergen, Moeller, Marcus J, Chatziantoniou, Christos, Prunotto, Marco

“…Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and…”
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Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1) by Fu, Hsueh-Liang, Valiathan, Rajeshwari R., Payne, Leo, Kumarasiri, Malika, Mahasenan, Kiran V., Mobashery, Shahriar, Huang, Paul, Fridman, Rafael

“…Discoidin domain receptor 1 (DDR1) belongs to a unique family of receptor tyrosine kinases that signal in response to collagens. DDR1 undergoes…”
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TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain by Jung, Young Suk, Liu, Xu-Wen, Chirco, Rosemarie, Warner, Richard B, Fridman, Rafael, Kim, Hyeong-Reh Choi

“…Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) regulate epithelial-mesenchymal transition (EMT) critical for the development of…”
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Discoidin Domain Receptors in Melanoma: Potential Therapeutic Targets to Overcome MAPK Inhibitor Resistance by Reger de Moura, Coralie, Prunotto, Marco, Sohail, Anjum, Battistella, Maxime, Jouenne, Fanelie, Marbach, Daniel, Lebbé, Celeste, Fridman, Rafael, Mourah, Samia

“…Melanoma is a highly malignant skin cancer with high propensity to metastasize and develop drug resistance, making it a difficult cancer to treat. Current…”
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Characterization of the Dimerization Interface of Membrane Type 4 (MT4)-Matrix Metalloproteinase by Sohail, Anjum, Marco, Marta, Zhao, Huiren, Shi, Qicun, Merriman, Scott, Mobashery, Shahriar, Fridman, Rafael

“…MT4-MMP (MMP17) belongs to a unique subset of membrane type-matrix metalloproteinases that are anchored to the cell surface via a glycosylphosphatidylinositol…”
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