Search Results - "FRIC, Jan"

Roles of IL‐2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy by Bendickova, Kamila, Fric, Jan

“…IL‐2 was initially characterized as a T cell growth factor in the 1970s, and has been studied intensively ever since. Decades of research have revealed…”
Get full text

Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy by Bendickova, Kamila, Tidu, Federico, Fric, Jan

“…Myeloid leucocytes mediate host protection against infection and critically regulate inflammatory responses in body tissues. Pattern recognition receptor…”
Get full text

How immune-cell fate and function are determined by metabolic pathway choice: The bioenergetics underlying the immune response by Hortová-Kohoutková, Marcela, Lázničková, Petra, Frič, Jan

“…Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient…”
Get full text

Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex? by Jose, Shyam Sushama, Bendickova, Kamila, Kepak, Tomas, Krenova, Zdenka, Fric, Jan

“…Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to…”
Get full text

Lactate from the tumor microenvironment - A key obstacle in NK cell-based immunotherapies by Jedlička, Marek, Feglarová, Tereza, Janstová, Lucie, Hortová-Kohoutková, Marcela, Frič, Jan

“…Recent findings about the new roles of lactate have changed our understanding of this end product of glycolysis or fermentation that was once considered only a…”
Get full text

Phagocytosis–Inflammation Crosstalk in Sepsis: New Avenues for Therapeutic Intervention by Hortová-Kohoutková, Marcela, Tidu, Federico, De Zuani, Marco, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…ABSTRACTPhagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by…”
Get full text

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? by Vymazal, Ondřej, Bendíčková, Kamila, De Zuani, Marco, Vlková, Marcela, Hortová-Kohoutková, Marcela, Frič, Jan

“…Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host…”
Get full text

NFAT control of innate immunity by Fric, Jan, Zelante, Teresa, Wong, Alicia Y.W., Mertes, Alexandra, Yu, Hong-Bing, Ricciardi-Castagnoli, Paola

“…The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates multiple adaptive T-cell functions, but recent studies have shown that…”
Get full text

High CD4‐to‐CD8 ratio identifies an at‐risk population susceptible to lethal COVID‐19 by De Zuani, Marco, Lazničková, Petra, Tomašková, Veronika, Dvončová, Martina, Forte, Giancarlo, Stokin, Gorazd Bernard, Šrámek, Vladimir, Helán, Martin, Frič, Jan

“…Around half of people with severe COVID‐19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS‐CoV‐2…”
Get full text

Human myeloid‐derived suppressor cell expansion during sepsis is revealed by unsupervised clustering of flow cytometric data by De Zuani, Marco, Hortová‐Kohoutková, Marcela, Andrejčinová, Ivana, Tomášková, Veronika, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…Myeloid‐derived suppressor cells (MDSCs) are important regulators of immune processes during sepsis in mice. However, confirming these observations in humans…”
Get full text

Calcineurin inhibitors reduce NFAT‐dependent expression of antifungal pentraxin‐3 by human monocytes by Bendíčková, Kamila, Tidu, Federico, De Zuani, Marco, Kohoutková, Marcela Hortová, Andrejčinová, Ivana, Pompeiano, Antonio, Bělášková, Silvie, Forte, Giancarlo, Zelante, Teresa, Frič, Jan

“…Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested…”
Get full text

Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn's disease by Ke, Bo-Jun, Abdurahiman, Saeed, Biscu, Francesca, Zanella, Gaia, Dragoni, Gabriele, Santhosh, Sneha, De Simone, Veronica, Zouzaf, Anissa, van Baarle, Lies, Stakenborg, Michelle, Bosáková, Veronika, Van Rymenant, Yentl, Verhulst, Emile, Verstockt, Sare, Klein, Elliott, Bislenghi, Gabriele, Wolthuis, Albert, Frič, Jan, Breynaert, Christine, D'Hoore, Andre, Van der Veken, Pieter, De Meester, Ingrid, Lovisa, Sara, Hawinkels, Lukas Jac, Verstockt, Bram, De Hertogh, Gert, Vermeire, Séverine, Matteoli, Gianluca

“…Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating…”
Get full text

Differences in monocyte subsets are associated with short‐term survival in patients with septic shock by Hortová‐Kohoutková, Marcela, Lázničková, Petra, Bendíčková, Kamila, De Zuani, Marco, Andrejčinová, Ivana, Tomášková, Veronika, Suk, Pavel, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic…”
Get full text

Lung Organoids—The Ultimate Tool to Dissect Pulmonary Diseases? by Bosáková, Veronika, De Zuani, Marco, Sládková, Lucie, Garlíková, Zuzana, Jose, Shyam Sushama, Zelante, Teresa, Hortová Kohoutková, Marcela, Frič, Jan

“…Organoids are complex multicellular three-dimensional (3D) in vitro models that are designed to allow accurate studies of the molecular processes and…”
Get full text

The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways by De Luca, Antonella, Pariano, Marilena, Cellini, Barbara, Costantini, Claudio, Villella, Valeria Rachela, Jose, Shyam Sushama, Palmieri, Melissa, Borghi, Monica, Galosi, Claudia, Paolicelli, Giuseppe, Maiuri, Luigi, Fric, Jan, Zelante, Teresa

“…The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or…”
Get full text

Comparison of two human organoid models of lung and intestinal inflammation reveals Toll‐like receptor signalling activation and monocyte recruitment by Jose, Shyam Sushama, De Zuani, Marco, Tidu, Federico, Hortová Kohoutková, Marcela, Pazzagli, Lucia, Forte, Giancarlo, Spaccapelo, Roberta, Zelante, Teresa, Frič, Jan

“…Objectives The activation of immune responses in mucosal tissues is a key factor for the development and sustainment of several pathologies including…”
Get full text

Targeted volatolomics of human monocytes: Comparison of 2D‐GC/TOF‐MS and 1D‐GC/Orbitrap‐MS methods by Zemánková, Kristýna, Pavelicová, Kristýna, Pompeiano, Antonio, Mravcová, Ludmila, Černý, Martin, Bendíčková, Kamila, Hortová Kohoutková, Marcela, Dryahina, Kseniya, Vaculovičová, Markéta, Frič, Jan, Vaníčková, Lucie

“…[Display omitted] •Two mass spectrometry methods were compared (GC/TOF-MS and GC/Orbitrap-MS).•2D-GC/TOF-MS allows for capturing wider range of monocyte…”
Get full text

Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence by Lázničková, Petra, Kepák, Tomáš, Hortová – Kohoutková, Marcela, Horváth, Luděk, Sheardová, Kateřina, Marciniak, Rafal, Vacca, Carmine, Šiklová, Michaela, Zelante, Teresa, Rossmeislová, Lenka, Křenová, Zdenka, Štěrba, Jaroslav, Bendíčková, Kamila, Frič, Jan

“…Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8+ T cell compartment and elevated plasma TNF‐α but in later follow‐up immune…”
Get full text

Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection by Paolicelli, Giuseppe, Luca, Antonella De, Jose, Shyam S, Antonini, Martina, Teloni, Irene, Fric, Jan, Zelante, Teresa

Get full text

CD103+ Dendritic Cells Control Th17 Cell Function in the Lung by Zelante, Teresa, Wong, Alicia Yoke Wei, Ping, Tang Jing, Chen, Jinmiao, Sumatoh, Hermi R., Viganò, Elena, Hong Bing, Yu, Lee, Bernett, Zolezzi, Francesca, Fric, Jan, Newell, Evan W., Mortellaro, Alessandra, Poidinger, Michael, Puccetti, Paolo, Ricciardi-Castagnoli, Paola

“…Th17 cells express diverse functional programs while retaining their Th17 identity, in some cases exhibiting a stem-cell-like phenotype. Whereas the importance…”
Get full text