Search Results - "FREZZA, Christian"

Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer by Sciacovelli, Marco, Frezza, Christian

“…Several lines of evidence indicate that during transformation epithelial cancer cells can acquire mesenchymal features via a process called…”
Get full text

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival by Gaude, Edoardo, Frezza, Christian

“…Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic…”
Get full text

The role of mitochondria in the oncogenic signal transduction by Frezza, Christian

“…Mitochondria are intracellular organelles thought to have evolved from an alphaproteobacterium engulfed by the ancestor of the eukaryotic cell, an archeon, two…”
Get full text

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy by Fendt, Sarah-Maria, Frezza, Christian, Erez, Ayelet

“…Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and survival while subject to changes in environmental cues. Thus, a…”
Get more information

Mitochondrial DNA: the overlooked oncogenome? by Gammage, Payam A, Frezza, Christian

“…Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result…”
Get full text

Metabolic synthetic lethality in cancer therapy by Zecchini, Vincent, Frezza, Christian

“…Our understanding of cancer has recently seen a major paradigm shift resulting in it being viewed as a metabolic disorder, and altered cellular metabolism…”
Get full text

Genome and metabolome: chance and necessity by Gonçalves, Emanuel, Frezza, Christian

“…[...]to a simple accumulation or combination of key “driver” mutations, oncogenesis might be driven by the interplay between the availability of healthy cells…”
Get full text

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts by Scorrano, Luca, Frezza, Christian, Cipolat, Sara

“…Mitochondria participate in key metabolic reactions of the cell and regulate crucial signaling pathways including apoptosis. Although several approaches are…”
Get full text

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury by Chouchani, Edward T., Pell, Victoria R., James, Andrew M., Work, Lorraine M., Saeb-Parsy, Kourosh, Frezza, Christian, Krieg, Thomas, Murphy, Michael P.

“…Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen…”
Get full text

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation by Fernandez-Antoran, David, Piedrafita, Gabriel, Murai, Kasumi, Ong, Swee Hoe, Herms, Albert, Frezza, Christian, Jones, Philip H.

“…As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring…”
Get full text

Predicting selective drug targets in cancer through metabolic networks by Folger, Ori, Jerby, Livnat, Frezza, Christian, Gottlieb, Eyal, Ruppin, Eytan, Shlomi, Tomer

“…The interest in studying metabolic alterations in cancer and their potential role as novel targets for therapy has been rejuvenated in recent years. Here, we…”
Get full text

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
Get full text

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency by Cogliati, Sara, Frezza, Christian, Soriano, Maria Eugenia, Varanita, Tatiana, Quintana-Cabrera, Ruben, Corrado, Mauro, Cipolat, Sara, Costa, Veronica, Casarin, Alberto, Gomes, Ligia C., Perales-Clemente, Ester, Salviati, Leonardo, Fernandez-Silva, Patricio, Enriquez, Jose A., Scorrano, Luca

“…Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or…”
Get full text

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS by Chouchani, Edward T., Pell, Victoria R., Gaude, Edoardo, Aksentijević, Dunja, Sundier, Stephanie Y., Robb, Ellen L., Logan, Angela, Nadtochiy, Sergiy M., Ord, Emily N. J., Smith, Anthony C., Eyassu, Filmon, Shirley, Rachel, Hu, Chou-Hui, Dare, Anna J., James, Andrew M., Rogatti, Sebastian, Hartley, Richard C., Eaton, Simon, Costa, Ana S. H., Brookes, Paul S., Davidson, Sean M., Duchen, Michael R., Saeb-Parsy, Kourosh, Shattock, Michael J., Robinson, Alan J., Work, Lorraine M., Frezza, Christian, Krieg, Thomas, Murphy, Michael P.

“…A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to…”
Get full text

Neural stem cells traffic functional mitochondria via extracellular vesicles by Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Willis, Cory M, Manferrari, Giulia, Rogall, Rebecca, Fernandez-Vizarra, Erika, Williamson, James C, Braga, Alice, van den Bosch, Aletta, Leonardi, Tommaso, Krzak, Grzegorz, Kittel, Ágnes, Benincá, Cristiane, Vicario, Nunzio, Tan, Sisareuth, Bastos, Carlos, Bicci, Iacopo, Iraci, Nunzio, Smith, Jayden A, Peacock, Ben, Muller, Karin H, Lehner, Paul J, Buzas, Edit Iren, Faria, Nuno, Zeviani, Massimo, Frezza, Christian, Brisson, Alain, Matheson, Nicholas J, Viscomi, Carlo, Pluchino, Stefano

“…Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous…”
Get full text

Convergent somatic mutations in metabolism genes in chronic liver disease by Ng, Stanley W. K., Rouhani, Foad J., Brunner, Simon F., Brzozowska, Natalia, Aitken, Sarah J., Yang, Ming, Abascal, Federico, Moore, Luiza, Nikitopoulou, Efterpi, Chappell, Lia, Leongamornlert, Daniel, Ivovic, Aleksandra, Robinson, Philip, Butler, Timothy, Sanders, Mathijs A., Williams, Nicholas, Coorens, Tim H. H., Teague, Jon, Raine, Keiran, Butler, Adam P., Hooks, Yvette, Wilson, Beverley, Birtchnell, Natalie, Naylor, Huw, Davies, Susan E., Stratton, Michael R., Martincorena, Iñigo, Rahbari, Raheleh, Frezza, Christian, Hoare, Matthew, Campbell, Peter J.

“…The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes 1 – 8 …”
Get full text

Serine is a natural ligand and allosteric activator of pyruvate kinase M2 by Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnès C. L., Maddocks, Oliver D. K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal

“…The M2 isoform of pyruvate kinase (PKM2) is a key glycolytic enzyme that is overexpressed in cancer cells; here, serine is shown to bind to and directly…”
Get full text

Cancer associated fibroblast FAK regulates malignant cell metabolism by Demircioglu, Fevzi, Wang, Jun, Candido, Juliana, Costa, Ana S. H., Casado, Pedro, de Luxan Delgado, Beatriz, Reynolds, Louise E., Gomez-Escudero, Jesus, Newport, Emma, Rajeeve, Vinothini, Baker, Ann-Marie, Roy-Luzarraga, Marina, Graham, Trevor A., Foster, Julie, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Balkwill, Frances R., Sosabowski, Jane, Cutillas, Pedro R., Frezza, Christian, Sancho, Patricia, Hodivala-Dilke, Kairbaan

“…Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we…”
Get full text

Inborn and acquired metabolic defects in cancer by Frezza, Christian, Pollard, Patrick J, Gottlieb, Eyal

“…The observation that altered metabolism is the fundamental cause of cancer was made by Otto Warburg nearly a century ago. However, the subsequent…”
Get full text

Fumarate induces redox-dependent senescence by modifying glutathione metabolism by Zheng, Liang, Cardaci, Simone, Jerby, Livnat, MacKenzie, Elaine D., Sciacovelli, Marco, Johnson, T. Isaac, Gaude, Edoardo, King, Ayala, Leach, Joshua D. G., Edrada-Ebel, RuAngelie, Hedley, Ann, Morrice, Nicholas A., Kalna, Gabriela, Blyth, Karen, Ruppin, Eytan, Frezza, Christian, Gottlieb, Eyal

“…Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. We combined…”
Get full text