Search Results - "FREVERT, Charles W"

Animal models of acute lung injury by Matute-Bello, Gustavo, Frevert, Charles W, Martin, Thomas R

“…Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline…”
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Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity by Frevert, Charles W., Felgenhauer, Jessica, Wygrecka, Malgorzata, Nastase, Madalina V., Schaefer, Liliana

“…It is evident that components of the extracellular matrix (ECM) act as danger-associated molecular patterns (DAMPs) through direct interactions with pattern…”
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Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions by Sawant, Kirti V., Sepuru, Krishna Mohan, Lowry, Emily, Penaranda, Brigith, Frevert, Charles W., Garofalo, Roberto P., Rajarathnam, Krishna

“…Chemokines play a crucial role in combating microbial infection by recruiting blood neutrophils to infected tissue. In mice, the chemokines Cxcl1/KC and…”
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Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation by Wight, Thomas N, Kang, Inkyung, Evanko, Stephen P, Harten, Ingrid A, Chang, Mary Y, Pearce, Oliver M T, Allen, Carys E, Frevert, Charles W

“…The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor…”
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Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling by Altman, Matthew C, Lai, Ying, Nolin, James D, Long, Sydney, Chen, Chien-Chang, Piliponsky, Adrian M, Altemeier, William A, Larmore, Megan, Frevert, Charles W, Mulligan, Michael S, Ziegler, Steven F, Debley, Jason S, Peters, Michael C, Hallstrand, Teal S

“…Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of…”
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Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection by Kang, Inkyung, Chang, Mary Y., Wight, Thomas N., Frevert, Charles W.

“…Proteoglycans (PGs) are complex, multifaceted molecules that participate in diverse interactions vital for physiological and pathological processes. As…”
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Interplay of extracellular matrix and leukocytes in lung inflammation by Wight, Thomas N., Frevert, Charles W., Debley, Jason S., Reeves, Stephen R., Parks, William C., Ziegler, Steven F.

“…•Leukocytes interact with lung extracellular matrix (ECM) during inflammation.•This interaction affects how leukocytes accumulate, migrate, and…”
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CFTR dysregulation drives active selection of the gut microbiome by Meeker, Stacey M, Mears, Kevin S, Sangwan, Naseer, Brittnacher, Mitchell J, Weiss, Eli J, Treuting, Piper M, Tolley, Nicholas, Pope, Christopher E, Hager, Kyle R, Vo, Anh T, Paik, Jisun, Frevert, Charles W, Hayden, Hillary S, Hoffman, Lucas R, Miller, Samuel I, Hajjar, Adeline M

“…Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with…”
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Defining the versican interactome in lung health and disease by Tang, Fengying, Brune, Jourdan E, Chang, Mary Y, Reeves, Stephen R, Altemeier, William A, Frevert, Charles W

“…The extracellular matrix (ECM) imparts critical mechanical and biochemical information to cells in the lungs. Proteoglycans are essential constituents of the…”
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STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response to Alternaria alternata by Valladao, Andrea C, Frevert, Charles W, Koch, Lisa K, Campbell, Daniel J, Ziegler, Steven F

“…Human asthma is a heterogeneous disease characterized by the expression of both Th2 and Th17 cytokines. In vitro and in vivo studies have shown a reciprocal…”
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Baseline serum syndecan-4 predicts prognosis after the onset of acute exacerbation of idiopathic interstitial pneumonia by Sato, Yuki, Tanino, Yoshinori, Wang, Xintao, Nikaido, Takefumi, Sato, Suguru, Misa, Kenichi, Togawa, Ryuichi, Frevert, Charles W, Munakata, Mitsuru

“…Patients with idiopathic interstitial pneumonia can experience acute respiratory worsening, also known as acute exacerbation, with a large deterioration on…”
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Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung by Ogden, Herbert Luke, Lai, Ying, Nolin, James D., An, Dowon, Frevert, Charles W., Gelb, Michael H., Altemeier, William A., Hallstrand, Teal S.

“…Abstract Secreted phospholipase A2 (sPLA2) enzymes release free fatty acids, including arachidonic acid, and generate lysophospholipids from phospholipids,…”
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East Coast Fever Caused by Theileria parva Is Characterized by Macrophage Activation Associated with Vasculitis and Respiratory Failure by Fry, Lindsay M, Schneider, David A, Frevert, Charles W, Nelson, Danielle D, Morrison, W Ivan, Knowles, Donald P

“…Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has…”
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Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs by Chang, Mary Y, Kang, Inkyung, Gale, Jr, Michael, Manicone, Anne M, Kinsella, Michael G, Braun, Kathleen R, Wigmosta, Tara, Parks, William C, Altemeier, William A, Wight, Thomas N, Frevert, Charles W

“…Growing evidence suggests that versican is important in the innate immune response to lung infection. Our goal was to understand the regulation of…”
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Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation by Gill, Sean E, Nadler, Samuel T, Li, Qinglang, Frevert, Charles W, Park, Pyong Woo, Chen, Peter, Parks, William C

“…Although neutrophils play critical roles in innate immunity, in excess these cells cause severe tissue damage. Thus, neutrophil activation must be tightly…”
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Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung by Dautel, Sydney E., Kyle, Jennifer E., Clair, Geremy, Sontag, Ryan L., Weitz, Karl K., Shukla, Anil K., Nguyen, Son N., Kim, Young-Mo, Zink, Erika M., Luders, Teresa, Frevert, Charles W., Gharib, Sina A., Laskin, Julia, Carson, James P., Metz, Thomas O., Corley, Richard A., Ansong, Charles

“…Lung immaturity is a major cause of morbidity and mortality in premature infants. Understanding the molecular mechanisms driving normal lung development could…”
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Syndecan-4 Inhibits the Development of Pulmonary Fibrosis by Attenuating TGF-β Signaling by Tanino, Yoshinori, Wang, Xintao, Nikaido, Takefumi, Misa, Kenichi, Sato, Yuki, Togawa, Ryuichi, Kawamata, Takaya, Kikuchi, Masami, Frevert, Charles W, Tanino, Mishie, Kojima, Tetsuhito, Shibata, Yoko

“…Syndecan-4 is a transmembrane heparan sulfate proteoglycan expressed in a variety of cells, and its heparan sulfate glycosaminoglycan side chains bind to…”
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Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation by Kang, Inkyung, Harten, Ingrid A., Chang, Mary Y., Braun, Kathleen R., Sheih, Alyssa, Nivison, Mary P., Johnson, Pamela Y., Workman, Gail, Kaber, Gernot, Evanko, Stephen P., Chan, Christina K., Merrilees, Mervyn J., Ziegler, Steven F., Kinsella, Michael G., Frevert, Charles W., Wight, Thomas N.

“…Viral infection is an exacerbating factor contributing to chronic airway diseases, such as asthma, via mechanisms that are still unclear…”
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Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection by Gill, Sean, Wight, Thomas N., Frevert, Charles W.

“…Exposure to viruses and bacteria results in lung infections and places a significant burden on public health. The innate immune system is an early warning…”
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Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry by Snyder, Jessica M., Washington, Ida M., Birkland, Timothy, Chang, Mary Y., Frevert, Charles W.

“…Versican, a chondroitin sulfate proteoglycan, is important in embryonic development, and disruption of the versican gene is embryonically lethal in the mouse…”
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