Search Results - "FRENKEL, Eugene"

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients by Frankel, Arthur E., Coughlin, Laura A., Kim, Jiwoong, Froehlich, Thomas W., Xie, Yang, Frenkel, Eugene P., Koh, Andrew Y.

“…This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma…”
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Nanoparticles for drug delivery in cancer treatment by Haley, Barbara, M.D, Frenkel, Eugene, M.D

“…Abstract Nanoparticles (size in nanometer range) provide a new mode of cancer drug delivery functioning as a carrier for entry through fenestrations in tumor…”
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Microchip-based immunomagnetic detection of circulating tumor cells by Hoshino, Kazunori, Huang, Yu-Yen, Lane, Nancy, Huebschman, Michael, Uhr, Jonathan W, Frenkel, Eugene P, Zhang, Xiaojing

“…Screening for circulating tumor cells (CTCs) in blood has been an object of interest for evidence of progressive disease, status of disease activity,…”
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The paradoxical effect of bevacizumab in the therapy of malignant gliomas by THOMPSON, Eric M, FRENKEL, Eugene P, NEUWELT, Edward A

“…One rationale behind the use of agents that inhibit vascular endothelial growth factor in the therapy of primary CNS malignancies is based upon the concept…”
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Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset by Mace, Emily M, Hsu, Amy P, Monaco-Shawver, Linda, Makedonas, George, Rosen, Joshua B, Dropulic, Lesia, Cohen, Jeffrey I, Frenkel, Eugene P, Bagwell, John C, Sullivan, John L, Biron, Christine A, Spalding, Christine, Zerbe, Christa S, Uzel, Gulbu, Holland, Steven M, Orange, Jordan S

“…Mutations in the transcription factor GATA2 underlie the syndrome of monocytopenia and B- and natural killer (NK)-cell lymphopenia associated with…”
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Versatile Immunomagnetic Nanocarrier Platform for Capturing Cancer Cells by Wu, Chun-Hsien, Huang, Yu-Yen, Chen, Peng, Hoshino, Kazunori, Liu, Huaying, Frenkel, Eugene P, Zhang, John X. J, Sokolov, Konstantin V

“…Sensitive and quantitative assessment of changes in circulating tumor cells (CTCs) can help in cancer prognosis and in the evaluation of therapeutics efficacy…”
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Circulating Tumor Cells in Patients with Breast Cancer Dormancy by Meng, Songdong, Tripathy, Debasish, Frenkel, Eugene P, Shete, Sanjay, Naftalis, Elizabeth Z, Huth, James F, Beitsch, Peter D, Leitch, Marilyn, Hoover, Susan, Euhus, David, Haley, Barbara, Morrison, Larry, Fleming, Timothy P, Herlyn, Dorothee, Terstappen, Leon W M M, Fehm, Tanja, Tucker, Thomas F, Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan W

“…Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells (CTCs) are present in patients many years after mastectomy without…”
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Analysis of Thrombophilia Test Ordering Practices at an Academic Center: A Proposal for Appropriate Testing to Reduce Harm and Cost by Shen, Yu-Min, Tsai, Judy, Taiwo, Evelyn, Gavva, Chakri, Yates, Sean G, Patel, Vivek, Frenkel, Eugene, Sarode, Ravi

“…Ideally, thrombophilia testing should be tailored to the type of thrombotic event without the influence of anticoagulation therapy or acute phase effects which…”
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Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL by Farrell, Brian T, Hamilton, Bronwyn E, Dósa, Edit, Rimely, Endre, Nasseri, Morad, Gahramanov, Seymur, Lacy, Cynthia A, Frenkel, Eugene P, Doolittle, Nancy D, Jacobs, Paula M, Neuwelt, Edward A

“…OBJECTIVE:The study goal was to assess the benefits and potential limitations in the use of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles in…”
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Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5 by Tian, Hui, Lu, Jui-Yun, Shao, Chunli, Huffman, Kenneth E, Carstens, Ryan M, Larsen, Jill E, Girard, Luc, Liu, Hui, Rodriguez-Canales, Jaime, Frenkel, Eugene P, Wistuba, Ignacio I, Minna, John D, Hofmann, Sandra L

“…Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein-membrane interactions, protein-protein interactions,…”
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HER-2 Gene Amplification Can Be Acquired as Breast Cancer Progresses by Meng, Songdong, Tripathy, Debasish, Shete, Sanjay, Ashfaq, Raheela, Haley, Barbara, Perkins, Steve, Beitsch, Peter, Khan, Amanullah, Euhus, David, Osborne, Cynthia, Frenkel, Eugene, Hoover, Susan, Leitch, Marilyn, Clifford, Edward, Vitetta, Ellen, Morrison, Larry, Herlyn, Dorothee, Leon W. M. M. Terstappen, Fleming, Timothy, Fehm, Tanja, Tucker, Thomas, Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan

“…Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor…”
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Immunomagnetic nanoscreening of circulating tumor cells with a motion controlled microfluidic system by Huang, Yu-yen, Hoshino, Kazunori, Chen, Peng, Wu, Chun-hsien, Lane, Nancy, Huebschman, Michael, Liu, Huaying, Sokolov, Konstantin, Uhr, Jonathan W., Frenkel, Eugene P., Zhang, John X.J.

“…Combining the power of immunomagnetic assay and microfluidic microchip operations, we successfully detected rare CTCs from clinical blood samples. The…”
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Preclinical antitumor activity of S‐222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2 by Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka

“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are validated molecular targets in cancer therapy. Dual blockade…”
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Aberrant Promoter Methylation Profile of Prostate Cancers and Its Relationship to Clinicopathological Features by MARUYAMA, Riichiroh, TOYOOKA, Shinichi, TOYOOKA, Kiyomi O, VIRMANI, Arvind K, ZÖCHBAUER-MÜLLER, Sabine, FARINAS, Alfredo J, MINNA, John D, MCCONNELL, John, FRENKEL, Eugene P, GAZDAR, Adi F

“…Purpose: We investigated the aberrant methylation profile of prostate cancers and correlated the data with clinical findings. Experimental Design: Gene…”
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Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines by Zhang, Wei, Peyton, Michael, Xie, Yang, Soh, Junichi, Minna, John D, Gazdar, Adi F, Frenkel, Eugene P

“…Most epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers (NSCLCs) are sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as…”
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uPAR and HER-2 Gene Status in Individual Breast Cancer Cells from Blood and Tissues by Meng, Songdong, Tripathy, Debu, Shete, Sanjay, Ashfaq, Raheela, Saboorian, Hossein, Haley, Barbara, Frenkel, Eugene, Euhus, David, Leitch, Marilyn, Osborne, Cynthia, Clifford, Edward, Perkins, Steve, Beitsch, Peter, Khan, Amanullah, Morrison, Larry, Herlyn, Dorothee, Terstappen, Leon W. M. M., Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan

“…Overexpression of urokinase plasminogen activator system or HER-2 (erbB-2) in breast cancer is associated with a poor prognosis. HER-2 overexpression is caused…”
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Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene by SHIVAPURKAR, Narayan, STASTNY, Victor, ROTH, Jack A, LILOGLOU, Triantafillos, XINARIANOS, George, FIELD, John K, MINNA, John D, GAZDAR, Adi F, OKUMURA, Naoki, GIRARD, Luc, YANG XIE, PRINSEN, Clemens, THUNNISSEN, Frederik B, WISTUBA, Ignacio I, CZERNIAK, Bogdan, FRENKEL, Eugene

“…Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region…”
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Retraction notice to “Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer” [Cancer Lett. 242 (2) (2006) 222–230] by Suzuki, Makoto, Shigematsu, Hisayuki, Shivapurkar, Narayan, Reddy, Jyotsna, Miyajima, Kuniharu, Takahashi, Takao, Gazdar, Adi F, Frenkel, Eugene P

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Loss of PBRM1 and BAP1 expression is less common in non–clear cell renal cell carcinoma than in clear cell renal cell carcinoma by Ho, Thai H., M.D., Ph.D, Kapur, Payal, M.D, Joseph, Richard W., M.D, Serie, Daniel J., B.S, Eckel-Passow, Jeanette E., Ph.D, Parasramka, Mansi, Ph.D, Cheville, John C., M.D, Wu, Kevin J., M.D, Frenkel, Eugene, M.D, Rakheja, Dinesh, M.D, Stefanius, Karoliina, Ph.D, Brugarolas, James, M.D., Ph.D, Parker, Alexander S., Ph.D

“…Abstract Background Recurrent mutations in polybromo-1 ( PBRM1 , ~40%) and BRCA1-associated protein-1 ( BAP1 , ~10%) occur in clear cell renal cell carcinoma…”
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Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference by WILLIAMS, Noelle Sevilir, GAYNOR, Richard B, SCOGGIN, Shane, VERMA, Udit, GOKASLAN, Tunc, SIMMANG, Clifford, FLEMING, Jason, TAVANA, Denise, FRENKEL, Eugene, BECERRA, Carlos

“…Purpose: The purpose of this study was to profile gene expression changes in colorectal tumors to identify new targets and strategies for the management of…”
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