Search Results - "FREMEAU, R. T"

Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter by Bellocchio, Elizabeth E., Reimer, Richard J., Fremeau, Robert T., Edwards, Robert H.

“…Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for…”
Get full text

The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse by Fremeau, Robert T, Troyer, Matthew D, Pahner, Ingrid, Nygaard, Gro Owren, Tran, Cindy H, Reimer, Richard J, Bellocchio, Elizabeth E, Fortin, Doris, Storm-Mathisen, Jon, Edwards, Robert H

“…The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of…”
Get full text

Cloning and expression of a functional serotonin transporter from rat brain by Blakely, Randy D, Berson, Haley E, Fremeau, Robert T, Caron, Marc G, Peek, Margaret M, Prince, Heather K, Bradley, Chris C

“…Selective antagonism of serotonin (5-hydroxytryptamine, 5HT) and noradrenaline transport by antidepressants is a key element in the 'amine' hypothesis of…”
Get full text

VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate by Fremeau, Robert T, Voglmaier, Susan, Seal, Rebecca P, Edwards, Robert H

“…Exocytotic release of the excitatory neurotransmitter glutamate depends on transport of this amino acid into synaptic vesicles. Recent work has identified a…”
Get full text

Dendritic Location of Neural BC1 RNA by Tiedge, Henri, Fremeau, Robert T., Weinstock, Peter H., Arancio, Ottavio, Brosius, Jurgen

“…In nerve cells, a specialized protein synthetic machinery is thought to operate in local compartments of dendrites, in particular beneath synaptic junctions,…”
Get full text

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor by M Tiberi, K R Jarvie, C Silvia, P Falardeau, J A Gingrich, N Godinot, L Bertrand, T L Yang-Feng, R T Fremeau, Jr, M G Caron

“…Multiple D1 dopaminergic receptor subtypes have been postulated on the basis of pharmacological, biochemical, and genetic studies. We describe the isolation…”
Get full text

Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission by R T Fremeau, Jr, G E Duncan, M G Fornaretto, A Dearry, J A Gingrich, G R Breese, M G Caron

“…Expression of a D1 dopamine receptor was examined in the rat brain by using a combination of in situ hybridization and in vitro receptor autoradiography. Cells…”
Get full text

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype by D A Schwinn, J W Lomasney, W Lorenz, P J Szklut, R T Fremeau, Jr, T L Yang-Feng, M G Caron, R J Lefkowitz, S Cotecchia

“…A novel alpha 1-adrenergic receptor subtype has been cloned from a bovine brain cDNA library. The deduced amino acid sequence is that of a 466-residue…”
Get full text

Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor by King, PH, Levine, TD, Fremeau, RT, Jr, Keene, JD

“…Mammalian cDNAs encoding a rat (Rel-N1) and a human (Hel-N1) neuronal RNA-binding protein have been cloned and characterized with respect to tissue…”
Get full text

Molecular cloning and expression of the gene for a human D1 dopamine receptor by DEARRY, A, GINGRICH, J. A, FALARDEAU, P, FREMEAU, R. T, BATES, M. D, CARON, M. G

“…The diverse physiological actions of dopamine are mediated by its interaction with two basic types of G protein-coupled receptor, D1 and D2, which stimulate…”
Get full text

Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding by Schambra, U B, Duncan, G E, Breese, G R, Fornaretto, M G, Caron, M G, Fremeau, Jr, R T

“…The prenatal and postnatal ontogeny of D1A and D2 dopamine receptors was assessed by in situ hybridization of messenger RNAs encoding the receptors and by…”
Get more information

Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters by S Shafqat, B K Tamarappoo, M S Kilberg, R S Puranam, J O McNamara, A Guadaño-Ferraz, R T Fremeau, Jr

“…A cDNA has been isolated from human hippocampus that appears to encode a novel Na(+)-dependent, Cl(-)-independent, neutral amino acid transporter. The putative…”
Get full text

The Mammalian Brain High-Affinity L-Proline Transporter Is Enriched Preferentially in Synaptic Vesicles in a Subpopulation of Excitatory Nerve Terminals in Rat Forebrain by Renick, Stephani E, Kleven, Dan T, Chan, June, Stenius, Katinka, Milner, Teresa A, Pickel, Virginia M, Fremeau, Robert T., Jr

“…The expression of a brain-specific high-affinity Na+-dependent (and Cl--dependent) L-proline transporter (PROT) in subpopulations of putative glutamatergic…”
Get full text

Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain by Fremeau, Jr, R T, Caron, M G, Blakely, R D

“…We have used the polymerase chain reaction (PCR) with degenerate oligonucleotides derived from two conserved regions of the norepinephrine and…”
Get more information

The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate by Fremeau, Robert T., Burman, Jonathon, Qureshi, Tayyaba, Tran, Cindy H., Proctor, John, Johnson, Juliette, Zhang, Hui, Sulzer, David, Copenhagen, David R., Storm-Mathisen, Jon, Reimer, Richard J., Chaudhry, Farrukh A., Edwards, Robert H.

“…Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the…”
Get full text

Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain by Velaz-Faircloth, M, McGraw, T S, alandro, M S, Fremeau, Jr, R T, Kilberg, M S, Anderson, K J

“…The extracellular concentration of glutamate and other related excitatory amino acids (EAA) is regulated by the action of transporter proteins located on…”
Get full text

Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes by Shafqat, S, Velaz-Faircloth, M, Henzi, V A, Whitney, K D, Yang-Feng, T L, Seldin, M F, Fremeau, Jr, R T

“…L-Proline fulfills several of the classic criteria used to identify amino acid neurotransmitters, including the presence of a high affinity, Na(+)- (and…”
Get more information

Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes by Velaz-Faircloth, M, Guadaño-Ferraz, A, Henzi, V A, Fremeau, Jr, R T

“…The expression of a high affinity Na(+)- (and Cl-) dependent L-proline transporter (PROT) in subpopulations of putative glutamatergic pathways in rat brain…”
Get full text

Diazepam Binding Inhibitor Gene Expression: Location in Brain and Peripheral Tissues of Rat by Alho, H., Fremeau, R. T., Tiedge, H., Wilcox, J., Bovolin, P., Brosius, J., Roberts, J. L., Costa, E.

“…Diazepam binding inhibitor (DBI), an endogenous 10-kDa polypeptide was isolated from rat and human brain by monitoring displacement of radioactive diazepam…”
Get full text

The essence of excitation by Reimer, Richard J, Fremeau Jr, Robert T, Bellocchio, Elizabeth E, Edwards, Robert H

“…The amino acid glutamate is the major excitatory neurotransmitter in a range of organisms from Caenorhabditis elegans to mammals, and it mediates the…”
Get full text