Search Results - "FREIBERG, C"

Novel Approach to Cell Surface Discrimination Between KIR2DL1 Subtypes and KIR2DS1 Identifies Hierarchies in NK Repertoire, Education, and Tolerance by Le Luduec, Jean-Benoît, Boudreau, Jeanette E, Freiberg, Julian C, Hsu, Katharine C

“…Cumulative activating and inhibitory receptor signaling controls the functional output of individual natural killer (NK) cells. Investigation of how competing…”
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Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration by Bublitz, S.K., Alhaddad, B., Synofzik, M., Kuhl, V., Lindner, A., Freiberg, C., Schmidt, H., Strom, T.M., Haack, T.B., Deschauer, M.

“…Identification of this additional patient from a distant part of the originally described pedigree (Synofzik et al. 2014) confirms pathogenicity of DNAJC3…”
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Discovering the Mechanism of Action of Novel Antibacterial Agents through Transcriptional Profiling of Conditional Mutants by FREIBERG, C, FISCHER, H. P, BRUNNER, N. A

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Novel Bacterial Acetyl Coenzyme A Carboxylase Inhibitors with Antibiotic Efficacy In Vivo by FREIBERG, C, POHLMANN, J, NELL, P. G, ENDERMANN, R, SCHUHMACHER, J, NEWTON, B, OTTENEDER, M, LAMPE, T, HÄBICH, D, ZIEGELBAUER, K

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An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% ( w / v ) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival by Freiberg, Josefine C, Hedengran, Anne, Heegaard, Steffen, Petrovski, Goran, Jacobsen, Jette, Cvenkel, Barbara, Kolko, Miriam

“…To examine the physicochemical properties of five preservative-free (PF) 0.005% latanoprost ophthalmic products; Monoprost , Latanest , Gaap Ofteno , Xalmono ,…”
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Can color-coded parametric maps improve dynamic enhancement pattern analysis in MR mammography? by Baltzer, P A, Dietzel, M, Vag, T, Beger, S, Freiberg, C, Herzog, A B, Gajda, M, Camara, O, Kaiser, W A

“…Post-contrast enhancement characteristics (PEC) are a major criterion for differential diagnosis in MR mammography (MRM). Manual placement of regions of…”
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YkrB is the main peptide deformylase in Bacillus subtilis, a eubacterium containing two functional peptide deformylases by Haas, Michael, Beyer, Dieter, Gahlmann, Reinhold, Freiberg, Christoph

“…Institute for Anti-infectives Research, Pharma Research, Bayer AG, D-42096 Wuppertal, Germany 1 Author for correspondence: Christoph Freiberg. Tel: +49 202…”
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Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome by Roth, C, Freiberg, C, Zappel, H, Albers, N

“…Testolactone is used to treat conditions with excessive estrogen synthesis, e.g. gonadotropin-independent precocious puberty in McCune-Albright syndrome (MAS)…”
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Structure and evolution of NGRRS-1, a complex, repeated element in the genome of Rhizobium sp. strain NGR234 by Perret, X, Viprey, V, Freiberg, C, Broughton, W.J

“…Much of the remarkable ability of Rhizobium sp. strain NGR234 to nodulate at least 110 genera of legumes, as well as the nonlegume Parasponia andersonii, stems…”
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nodD2 of Rhizobium sp. NGR234 is involved in the repression of the nodABC operon by Fellay, R., Hanin, M., Montorzi, G., Frey, J., Freiberg, C., Golinowski, W., Staehelin, C., Broughton, W.J., Jabbouri, S.

“…Transcriptional regulators of the lysR family largely control the expression of bacterial symbiotic genes. Rhizobium sp. NGR234 contains at least four members…”
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Sulphation of Rhizobium sp. NGR234 Nod factors is dependent on noeE, a new host‐specificity gene by Hanin, M., Jabbouri, S., Quesada‐Vincens, D., Freiberg, C., Perret, X., Promé, J.‐C., Broughton, W. J., Fellay, R.

“…Rhizobia secrete specific lipo‐chitooligosaccharide signals (LCOs) called Nod factors that are required for infection and nodulation of legumes. In Rhizobium…”
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Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria by Freiberg, C, Wieland, B, Spaltmann, F, Ehlert, K, Brötz, H, Labischinski, H

“…We deleted a subset of 27 open reading frames (ORFs) from Escherichia coli which encode previously uncharacterized, probably soluble gene products homologous…”
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Identification and Characterization of the First Class of Potent Bacterial Acetyl-CoA Carboxylase Inhibitors with Antibacterial Activity by Freiberg, Christoph, Brunner, Nina A., Schiffer, Guido, Lampe, Thomas, Pohlmann, Jens, Brands, Michael, Raabe, Martin, Häbich, Dieter, Ziegelbauer, Karl

“…The multisubunit acetyl-CoA carboxylase, which catalyzes the first committed step in fatty acid biosynthesis, is broadly conserved among bacteria. Its…”
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Functional genomics in antibacterial drug discovery by Freiberg, Christoph, Brötz-Oesterhelt, Heike

“…Modern antibacterial drug discovery relies on various functional genomics techniques for target validation and determination of the mechanism of action of…”
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Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling by HUTTER, Bernd, SCHAAB, Christoph, ALBRECHT, Sebastian, BORGMANN, Matthias, BRUNNER, Nina A, FREIBERG, Christoph, ZIEGELBAUER, Karl, ROCK, Charles O, IVANOV, Igor, LOFERER, Hannes

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Novel computational methods in anti-microbial target identification by Freiberg, Christoph

“…The large number of microbial genome sequences currently available facilitates completely new methods of cross-genome analyses, which aid in target…”
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The impact of transcriptome and proteome analyses on antibiotic drug discovery by Freiberg, Christoph, Brötz-Oesterhelt, Heike, Labischinski, Harald

“…Recent scientific publications demonstrate the increasing interest in measurement of genome-wide gene expression on transcript and protein level in response to…”
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Molecular basis of symbiosis between Rhizobium and legumes by Freiberg, Christoph, Fellay, Rémy, Bairoch, Amos, Broughton, William J, Rosenthal, André, Perret, Xavier

“…Access to mineral nitrogen often limits plant growth, and so symbiotic relationships have evolved between plants and a variety of nitrogen-fixing organisms…”
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Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action by Pohlmann, Jens, Lampe, Thomas, Shimada, Mitsuyuki, Nell, Peter G., Pernerstorfer, Josef, Svenstrup, Niels, Brunner, Nina A., Schiffer, Guido, Freiberg, Christoph

“…Pyrrolidinediones represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure–activity relationships for the pyrrolidinedione…”
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Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery by Fischer, Hans Peter, Brunner, Nina A, Wieland, Bernd, Paquette, Jesse, Macko, Ludwig, Ziegelbauer, Karl, Freiberg, Christoph

“…As present antibiotics therapy becomes increasingly ineffectual, new technologies are required to identify and develop novel classes of antibacterial agents…”
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