Search Results - "FREEMAN, Tracy A"

Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model by Matsuda, Takeaki, Freeman, Tracy A., Hilbert, David W., Duff, Michael, Fuortes, Michele, Stapleton, Philip P., Daly, John M.

“…Lysis-deficient (LyD) bacteriophages (phages) kill bacteria without endotoxin (Et) release. This may minimize systemic cytokine responses and limit…”
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Glucocorticoid pretreatment induces cytokine overexpression and nuclear factor-κB activation in macrophages by Smyth, Gordon P., Stapleton, Philip P., Freeman, Tracy A., Concannon, Erin M., Mestre, Juan R., Duff, Michael, Maddali, Sirish, Daly, John M.

“…Glucocorticoids are widely used in treating inflammatory diseases. The contribution of adrenal glucocorticoids to inflammatory regulation is unknown…”
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Renal cell carcinoma induces prostaglandin E2 and T-helper type 2 cytokine production in peripheral blood mononuclear cells by Smyth, Gordon P, Stapleton, Philip P, Barden, Catherine B, Mestre, Juan R, Freeman, Tracy A, Duff, Michael D, Maddali, Sirish, Yan, Zhaoping, Daly, John M

“…Patients with renal cell carcinoma (RCC) do not develop an effective antitumor immune response, despite significant infiltration by lymphocytes. Tumor…”
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NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model by Nishikawa, Masayasu, Stapleton, Philip P., Freeman, Tracy A., Gaughan, John P., Matsuda, Takeaki, Daly, John M.

“…Cyclooxygenase-2 (COX-2) is overexpressed in colon cancers. The plasminogen activation (PA) system relates to cancer invasion and metastasis through the…”
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Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma by Duff, Michael, Stapleton, Philip P, Mestre, Juan R, Maddali, Sirish, Smyth, Gordon P, Yan, Zhaoping, Freeman, Tracy A, Daly, John M

“…Melanoma inhibits macrophage tumoricidal activity and increases the expression of cyclooxygenase-2 (COX-2). In this study, we sought to determine whether…”
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Neuroendocrine responses mediate macrophage function after trauma by Maddali, Sirish, Stapleton, Philip P., Freeman, Tracy A., Smyth, Gordon P., Duff, Michael, Yan, Zhaoping, Daly, John M.

“…Clearly understanding the interactions between macrophage (Mφ)-generated inflammatory mediators and the neuroendocrine system in regulating immune function…”
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NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model1 by Nishikawa, Masayasu, Stapleton, Philip P., Freeman, Tracy A., Gaughan, John P., Matsuda, Takeaki, Daly, John M.

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Decreased peritoneal macrophage NF-κB translocation to the nucleus in protein energy malnutrition—a role for the glucocorticoid response? by Stapleton, Philip P, Barry, Linda K, Freeman, Tracy A, Mestre, Juan R, Daly, John M

“…Background & aims: Protein energy malnutrition (PEM) induces immune suppression leading to increased morbidity and mortality. The mechanism(s) underlying…”
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Gender affects macrophage cytokine and prostaglandin E2 production and PGE2 receptor expression after trauma1 by Stapleton, Philip P., Strong, Vivian E. Mack, Freeman, Tracy A., Winter, Jordan, Yan, Zhaoping, Daly, John M.

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Cyclooxygenase-2 Inhibition Improves Macrophage Function in Melanoma and Increases the Antineoplastic Activity of Interferon ? by Duff, Michael, Stapleton, Philip P., Mestre, Juan R., Maddali, Sirish, Smyth, Gordon P., Yan, Zhaoping, Freeman, Tracy A., Daly, John M.

“…Background: Melanoma inhibits macrophage tumoricidal activity and increases the expression of cyclooxygenase-2 (COX-2). In this study, we sought to determine…”
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Altered cyclooxygenase-2 expression and nitric oxide metabolism following major elective surgery by Maddali, Sirish, Stapleton, Philip P., Freeman, Tracy A., Yan, Zhaoping, Duff, Michael, Smyth, Gordon P., Daly, John M.

“…Postoperative variation in immune function leads to increased susceptibility to infections. Cyclooxygenase-2 (COX-2)-generated Prostaglandin-E 2 (PGE 2), which…”
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Serum leptin levels in acute protein deprivation by Stapleton, PP, Barden, CB, McCarter, MD, Mackrell, PJ, Freeman, TA, Naama, HA, Daly, JM

“…BACKGROUND: Protein energy malnutrition (PEM) induces a host neuroendocrine response, reflected by significant elevations in circulating glucocorticoid levels…”
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Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-κB mechanisms by Yan, Zhaoping, Stapleton, Philip P., Freeman, Tracy A., Fuortes, Michele, Daly, John M.

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Enhanced expression of cyclooxygenase-2 and prostaglandin E 2 in response to endotoxin after trauma is dependent on MAPK and NF-κB mechanisms by Yan, Zhaoping, Stapleton, Philip P., Freeman, Tracy A., Fuortes, Michele, Daly, John M.

“…Macrophage prostaglandin E 2 (PGE 2) production is important in cellular immune suppression and in affecting the potential development of sepsis after trauma…”
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Genetic ablation of iNOS modulates pro-inflammatory cytokine levels after trauma and confers a survival advantage following infectious challenge by Stapleton, Philip P., Freeman, Tracy A., Monroy, M.Alexandra, Daly, John M.

“…Introduction: Significant immune changes occur after trauma. Prostaglandin-E2 (PGE2) and nitric oxide (NO ) are key inflammatory mediators involved in…”
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Delayed fracture healing in iNOS knockout mice by Safadi, Fayez F., Stapleton, Philip P., Freeman, Tracy A., Casteneda, Julian L., Arango, Israel, Popoff, Steven N., Daly, John M.

“…Introduction: Inducible nitric oxide synthase (iNOS) is expressed in osteoblasts and is detected in the initial stages of fracture healing with expression…”
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Decreased peritoneal macrophage NF-kappaB translocation to the nucleus in protein energy malnutrition--a role for the glucocorticoid response? by Stapleton, Philip P, Barry, Linda K, Freeman, Tracy A, Mestre, Juan R, Daly, John M

“…Protein energy malnutrition (PEM) induces immune suppression leading to increased morbidity and mortality. The mechanism(s) underlying PEM-mediated immune…”
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Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-kappaB mechanisms by Yan, Zhaoping, Stapleton, Philip P, Freeman, Tracy A, Fuortes, Michele, Daly, John M

“…Macrophage prostaglandin E2 (PGE2) production is important in cellular immune suppression and in affecting the potential development of sepsis after trauma. We…”
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Gender affects macrophage cytokine and prostaglandin E 2 production and PGE 2 receptor expression after trauma 1 by Stapleton, Philip P., Strong, Vivian E. Mack, Freeman, Tracy A., Winter, Jordan, Yan, Zhaoping, Daly, John M.

“…Gender influences morbidity and mortality after injury. Hormonal differences are important; however, the role of prostaglandins as mediators in immune…”
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Gender affects macrophage cytokine and prostaglandin E2 production and PGE2 receptor expression after trauma by STAPLETON, Philip P, STRONG, Vivian E, FREEMAN, Tracy A, WINTER, Jordan, ZHAOPING YAN, DALY, John M

“…Gender influences morbidity and mortality after injury. Hormonal differences are important; however, the role of prostaglandins as mediators in immune…”
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