Search Results - "FREEMAN, Melanie"

ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER by Weigel, Aubrey V., Chang, Chi-Lun, Shtengel, Gleb, Xu, C. Shan, Hoffman, David P., Freeman, Melanie, Iyer, Nirmala, Aaron, Jesse, Khuon, Satya, Bogovic, John, Qiu, Wei, Hess, Harald F., Lippincott-Schwartz, Jennifer

“…Cellular versatility depends on accurate trafficking of diverse proteins to their organellar destinations. For the secretory pathway (followed by approximately…”
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5-Year Outcome After Transcatheter Aortic Valve Implantation by Toggweiler, Stefan, MD, Humphries, Karin H., DSc, Lee, May, MSc, Binder, Ronald K., MD, Moss, Robert R., MD, Freeman, Melanie, MBBS, Ye, Jian, MD, Cheung, Anson, MD, Wood, David A., MD, Webb, John G., MD

“…Objectives The purpose of this study was to investigate the 5-year outcome following transcatheter aortic valve implantation (TAVI). Background Little is known…”
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Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells by Hoffman, David P, Shtengel, Gleb, Xu, C Shan, Campbell, Kirby R, Freeman, Melanie, Wang, Lei, Milkie, Daniel E, Pasolli, H Amalia, Iyer, Nirmala, Bogovic, John A, Stabley, Daniel R, Shirinifard, Abbas, Pang, Song, Peale, David, Schaefer, Kathy, Pomp, Wim, Chang, Chi-Lun, Lippincott-Schwartz, Jennifer, Kirchhausen, Tom, Solecki, David J, Betzig, Eric, Hess, Harald F

“…Within cells, the spatial compartmentalization of thousands of distinct proteins serves a multitude of diverse biochemical needs. Correlative super-resolution…”
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Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III by Chang, Chi-Lun, Weigel, Aubrey V, Ioannou, Maria S, Pasolli, H Amalia, Xu, C Shan, Peale, David R, Shtengel, Gleb, Freeman, Melanie, Hess, Harald F, Blackstone, Craig, Lippincott-Schwartz, Jennifer

“…Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary…”
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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility by Sheu, Shu-Hsien, Upadhyayula, Srigokul, Dupuy, Vincent, Pang, Song, Deng, Fei, Wan, Jinxia, Walpita, Deepika, Pasolli, H Amalia, Houser, Justin, Sanchez-Martinez, Silvia, Brauchi, Sebastian E, Banala, Sambashiva, Freeman, Melanie, Xu, C Shan, Kirchhausen, Tom, Hess, Harald F, Lavis, Luke, Li, Yulong, Chaumont-Dubel, Séverine, Clapham, David E

“…Chemical synapses between axons and dendrites mediate neuronal intercellular communication. Here, we describe a synapse between axons and primary cilia: the…”
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5-Year Experience With Transcatheter Transapical Mitral Valve-in-Valve Implantation for Bioprosthetic Valve Dysfunction by Cheung, Anson, MD, Webb, John G., MD, Barbanti, Marco, MD, Freeman, Melanie, MD, Binder, Ronald K., MD, Thompson, Christopher, MD, Wood, David A., MD, Ye, Jian, MD

“…Objectives The study sought to describe the authors' experience with mitral transapical transcatheter valve-in-valve implantation (TVIV). Background Increasing…”
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Prognostic Value of Fat Mass and Skeletal Muscle Mass Determined by Computed Tomography in Patients Who Underwent Transcatheter Aortic Valve Implantation by Mok, Michael, MBBS, Allende, Ricardo, MD, Leipsic, Jonathon, MD, Altisent, Omar Abdul-Jawad, MD, del Trigo, Maria, MD, Campelo-Parada, Francisco, MD, DeLarochellière, Robert, MD, Dumont, Eric, MD, Doyle, Daniel, MD, Côté, Mélanie, MSc, Freeman, Melanie, MBBS, Webb, John, MD, Rodés-Cabau, Josep, MD

“…Body composition (fat mass [FM] and skeletal muscle mass [SMM]) predicts clinical outcomes. In particular, loss of SMM (sarcopenia) is associated with frailty…”
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Sex Differences in Mortality After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis by Humphries, Karin H., DSc, Toggweiler, Stefan, MD, Rodés-Cabau, Josep, MD, Nombela-Franco, Luis, MD, Dumont, Eric, MD, Wood, David A., MD, Willson, Alexander B., MD, Binder, Ronald K., MD, Freeman, Melanie, MD, Lee, May K., MSc, Gao, Min, PhD, Izadnegahdar, Mona, MSc, Ye, Jian, MD, Cheung, Anson, MD, Webb, John G., MD

“…Objectives The aim of this study was to examine sex differences in outcome after transcatheter aortic valve replacement (TAVR) with real-world data from 2…”
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Cap-dependent translation initiation monitored in living cells by Gandin, Valentina, English, Brian P., Freeman, Melanie, Leroux, Louis-Philippe, Preibisch, Stephan, Walpita, Deepika, Jaramillo, Maritza, Singer, Robert H.

“…mRNA translation is tightly regulated to preserve cellular homeostasis. Despite extensive biochemical, genetic, and structural studies, a detailed…”
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Impact of Post-Implant SAPIEN XT Geometry and Position on Conduction Disturbances, Hemodynamic Performance, and Paravalvular Regurgitation by Binder, Ronald K., MD, Webb, John G., MD, Toggweiler, Stefan, MD, Freeman, Melanie, MBBS, Barbanti, Marco, MD, Willson, Alexander B., MBBS, MD, Alhassan, Donya, MD, Hague, Cameron J., MD, Wood, David A., MD, Leipsic, Jonathon, MD

“…Objectives This report sought to study the impact of the balloon-expandable SAPIEN XT (Edwards Lifesciences, Irvine, California) transcatheter heart valve…”
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Underexpansion and Ad Hoc Post-Dilation in Selected Patients Undergoing Balloon-Expandable Transcatheter Aortic Valve Replacement by Barbanti, Marco, MD, Leipsic, Jonathon, MD, Binder, Ronald, MD, Dvir, Danny, MD, Tan, John, MD, Freeman, Melanie, MBBS, Norgaard, Bjarne, MD, Hansson, Nicolaj, MD, Cheung, Anson, MD, Ye, Jian, MD, Yang, Tae-Hyun, MD, Maryniak, Kasia, MD, Raju, Rekha, MD, Thompson, Angus, MBBS, PhD, Blanke, Philipp, MD, Lauck, Sandra, PhD, RN, Wood, David, MD, Webb, John, MD

“…Objectives This study sought to assess the clinical outcomes and hemodynamic performance associated with a strategy of underexpanding balloon-expandable…”
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Prevalence and impact of preoperative moderate/severe tricuspid regurgitation on patients undergoing transcatheter aortic valve replacement by Barbanti, Marco, Binder, Ronald K., Dvir, Danny, Tan, John, Freeman, Melanie, Thompson, Christopher R., Cheung, Anson, Wood, David A., Leipsic, Jonathon, Webb, John G.

“…Objectives Significant tricuspid regurgitation (TR) is a marker for late‐stage myocardial and valvular heart disease. Whether preoperative TR affects clinical…”
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Management of Vascular Access in Transcatheter Aortic Valve Replacement by Toggweiler, Stefan, MD, Leipsic, Jonathon, MD, Binder, Ronald K., MD, Freeman, Melanie, MBBS, Barbanti, Marco, MD, Heijmen, Robin H., MD, PhD, Wood, David A., MD, Webb, John G., MD

“…Transcatheter aortic valve implantation (TAVI) has emerged as a new therapy for patients with severe aortic stenosis who are inoperable or at very high risk of…”
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Guidance for elective single-embryo transfer should be applied to frozen embryo transfer cycles by Freeman, Melanie R., Hinds, M. Shaun, Howard, Kay G., Howard, Julie M., Hill, George A.

“…Purpose To provide clinicians with data showing the benefits of transferring a single blastocyst in frozen embryo transfer (FET) cycles so that they may…”
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Embryo disposition: choices made by patients and donor oocyte recipients by Hill, George A., M.D, Freeman, Melanie R., Ph.D

“…Objective To compare final embryo disposition between patients and donor oocyte recipients. Design Retrospective study. Setting Private infertility practice…”
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Outcomes of cardiogenic shock complicating acute coronary syndromes by Noaman, Samer, Andrianopoulos, Nick, Brennan, Angela L., Dinh, Diem, Reid, Christopher, Stub, Dion, Biswas, Sinjini, Clark, David, Shaw, James, Ajani, Andrew, Freeman, Melanie, Yip, Thomas, Oqueli, Ernesto, Walton, Antony, Duffy, Stephen J., Chan, William

“…Objectives We aimed to assess the outcomes of cardiogenic shock (CS) complicating acute coronary syndromes (ACS). Background CS remains the leading cause of…”
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Impact of low-profile sheaths on vascular complications during transfemoral transcatheter aortic valve replacement by Barbanti, Marco, Binder, Ronald K, Freeman, Melanie, Wood, David A, Leipsic, Jonathon, Cheung, Anson, Ye, Jian, Tan, John, Toggweiler, Stefan, Yang, Tae-Hyun, Dvir, Danny, Maryniak, Kasia, Lauck, Sandra, Webb, John G

“…We sought to assess the impact of low-profile sheaths on vascular complications during transfemoral transcatheter aortic valve replacement (TAVR). This…”
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Usefulness of Retinal Microvascular Endothelial Dysfunction as a Predictor of Coronary Artery Disease by Al-Fiadh, Ali H., MBChB, PhD, Wong, Tien Y., MD, MPH, PhD, Kawasaki, Ryo, MD, MPH, Clark, David J., MBBS, Patel, Sheila K., PhD, Freeman, Melanie, MBBS, Wilson, Andrew, MBBS, PhD, Burrell, Louise M., MBChB, MD, Farouque, Omar, MBBS (Hons), PhD

“…Endothelial dysfunction is a key feature of atherosclerosis. Retinal microvascular endothelial function can be assessed using noninvasive dynamic vessel…”
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The Receptor for Advanced Glycation End Products (RAGE) Is Associated with Persistent Atrial Fibrillation by Lancefield, Terase F, Patel, Sheila K, Freeman, Melanie, Velkoska, Elena, Wai, Bryan, Srivastava, Piyush M, Horrigan, Mark, Farouque, Omar, Burrell, Louise M

“…Upregulation of the receptor for advanced glycation end products (RAGE) has been proposed as a pathophysiological mechanism underlying the development of…”
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Transcatheter Valve-In-Valve Implantation for Failed Balloon-Expandable Transcatheter Aortic Valves by Toggweiler, Stefan, MD, Wood, David A., MD, Rodés-Cabau, Josep, MD, Kapadia, Samir, MD, Willson, Alexander B., MBBS, MPH, Ye, Jian, MD, Cheung, Anson, MD, Leipsic, Jonathon, MD, Binder, Ronald K., MD, Gurvitch, Ronen, MBBS, Freeman, Melanie, MBBS, Thompson, Christopher R., MD, Svensson, Lars G., MD, Dumont, Eric, MD, Tuzcu, E. Murat, MD, Webb, John G., MD

“…Objectives This study sought to evaluate outcomes after implantation of a second transcatheter heart valve (THV-in-THV) for acute THV failure. Background…”
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