Search Results - "FREEMAN, Craig"

Neutralizing the pathological effects of extracellular histones with small polyanions by Meara, Connor H. O’, Coupland, Lucy A., Kordbacheh, Farzaneh, Quah, Benjamin J. C., Chang, Chih-Wei, Simon Davis, David A., Bezos, Anna, Browne, Anna M., Freeman, Craig, Hammill, Dillon J., Chopra, Pradeep, Pipa, Gergely, Madge, Paul D., Gallant, Esther, Segovis, Courtney, Dulhunty, Angela F., Arnolda, Leonard F., Mitchell, Imogen, Khachigian, Levon M., Stephens, Ross W., von Itzstein, Mark, Parish, Christopher R.

“…Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by…”
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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease by Cui, Hao, Freeman, Craig, Jacobson, Glenn A., Small, David H.

“…Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central…”
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Multiplexed shotgun genotyping resolves species relationships within the North American genus Penstemon by Wessinger, Carolyn A., Freeman, Craig C., Mort, Mark E., Rausher, Mark D., Hileman, Lena C.

“…PREMISE OF THE STUDY: Evolutionary radiations provide opportunities to examine large-scale patterns in diversification and character evolution, yet are often…”
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Field-Scale Simulation of Production from Oceanic Gas Hydrate Deposits by Reagan, Matthew T., Moridis, George J., Johnson, Jeffery N., Pan, Lehua, Freeman, Craig M., Boyle, Katie L., Keen, Noel D., Husebo, Jarle

“…The quantity of hydrocarbon gases trapped in natural hydrate accumulations is enormous, leading to a significant interest in the evaluation of their potential…”
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Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans by Simeonovic, Charmaine J, Popp, Sarah K, Starrs, Lora M, Brown, Debra J, Ziolkowski, Andrew F, Ludwig, Barbara, Bornstein, Stefan R, Wilson, J Dennis, Pugliese, Alberto, Kay, Thomas W H, Thomas, Helen E, Loudovaris, Thomas, Choong, Fui Jiun, Freeman, Craig, Parish, Christopher R

“…Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of…”
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Nomenclatural novelties and notes in Penstemon (Plantaginaceae) by Freeman, Craig C

“…Seven nomenclatural novelties in (Plantaginaceae) are proposed for taxa that will be included in the forthcoming treatment of the genus in the Flora of North…”
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The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs by Freeman, Craig G, Parish, Christopher R, Knox, Karen J, Blackmore, Jessica L, Lobov, Sergei A, King, David W, Senden, Tim J, Stephens, Ross W

“…Abstract Recent findings on the role of circulating histone proteins in mediating acute lung injury prompted us to investigate whether there is a specific…”
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Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses by Lee, Eva, Pavy, Megan, Young, Nicolie, Freeman, Craig, Lobigs, Mario

“…Many viruses, including flaviviruses, display affinity for cell surface heparan sulfate (HS) proteoglycans with biological relevance in virus attachment/entry…”
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A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer by JOYCE, Johanna A, FREEMAN, Craig, MEYER-MORSE, Nicole, PARISH, Christopher R, HANAHAN, Douglas

“…Heparan sulfate proteoglycans are integral components of the extracellular matrix that surrounds all mammalian cells. In addition to providing structural…”
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Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D by McColl, Bradley K, Baldwin, Megan E, Roufail, Sally, Freeman, Craig, Moritz, Robert L, Simpson, Richard J, Alitalo, Kari, Stacker, Steven A, Achen, Marc G

“…Vascular endothelial growth factor (VEGF) C and VEGF-D stimulate lymphangiogenesis and angiogenesis in tissues and tumors by activating the endothelial cell…”
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Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice by Cui, Hao, Hung, Amos C, Klaver, David W, Suzuki, Toshiharu, Freeman, Craig, Narkowicz, Christian, Jacobson, Glenn A, Small, David H

“…Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP…”
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ABLS Library of the State Library of North Carolina: Profile of Accessibility by Freeman, Craig

“…The Accessible Books and Library Services (ABLS) Library of the State Library of North Carolina (SLNC) is a unique resource that caters to the needs of persons…”
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The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes by He, Yi Qing, Sutcliffe, Elissa L., Bunting, Karen L., Li, Jasmine, Goodall, Katharine J., Poon, Ivan K.A., Hulett, Mark D., Freeman, Craig, Zafar, Anjum, McInnes, Russell L., Taya, Toshiki, Parish, Christopher R., Rao, Sudha

“…The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone…”
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Human platelet heparanase: purification, characterization and catalytic activity by Freeman, C, Parish, C R

“…Heparan sulphate (HS) is an important component of the extracellular matrix (ECM) and the vasculature basal lamina (BL) which functions as a barrier to the…”
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The Impact of Television Viewing on Perceptions of Juvenile Crime by Goidel, Robert K., Freeman, Craig M., Procopio, Steven T.

“…This article examines the relationship between television viewing and public perceptions of juvenile crime rates and the effectiveness of the juvenile justice…”
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SeTES: A self-teaching expert system for the analysis, design, and prediction of gas production from unconventional gas resources by Moridis, George J., Reagan, Matthew T., Anderson Kuzma, Heidi, Blasingame, Thomas A., Wayne Huang, Y., Santos, Ralph, Boyle, Katie L., Freeman, Craig M., Ilk, Dilhan, Cossio, Manuel, Bhattacharya, Srimoyee, Nikolaou, Michael

“…SeTES is a self-teaching expert system that (a) can incorporate evolving databases involving any type and amount of relevant data (geological, geophysical,…”
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Heparanase in primary human osteoblasts by Smith, Paul N., Freeman, Craig, Yu, Di, Chen, Mingming, Gatenby, Paul A., Parish, Christopher R., Li, Rachel W.

“…Heparanase (HPSE) is known to be involved in fracture repair in mice, but its presence and function in human bone formation remains unclear. Our aim was to…”
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Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins by Freeman, Craig, Liu, Ligong, Banwell, Martin G., Brown, Kathryn J., Bezos, Anna, Ferro, Vito, Parish, Christopher R.

“…Heparin and heparan sulfate (HS) are structurally diverse glycosaminoglycans (GAG) that are known to interact, via unique structural motifs, with a wide range…”
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Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion by Takahashi, Hisaaki, Matsumoto, Hiroaki, Kumon, Yoshiaki, Ohnishi, Takanori, Freeman, Craig, Imai, Yoshinori, Tanaka, Junya

“…Heparanase is an enzyme that cleaves heparan sulfate proteoglycans, an important component of the extracellular matrix to generate heparan sulfate fragments,…”
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Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis by Hulett, Mark D., Freeman, Craig, Hamdorf, Brenton J., Baker, Rohan T., Harris, Matthew J., Parish, Christopher R.

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