Search Results - "FREEDMAN, Steven"

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome by Witztum, Joseph L, Gaudet, Daniel, Freedman, Steven D, Alexander, Veronica J, Digenio, Andres, Williams, Karren R, Yang, Qingqing, Hughes, Steven G, Geary, Richard S, Arca, Marcello, Stroes, Erik S.G, Bergeron, Jean, Soran, Handrean, Civeira, Fernando, Hemphill, Linda, Tsimikas, Sotirios, Blom, Dirk J, O’Dea, Louis, Bruckert, Eric

“…This phase 3 trial showed that treatment with volanesorsen, an antisense oligonucleotide drug complementary to mRNA encoding apolipoprotein C-III, resulted in…”
Get full text

Cystic fibrosis by O'Sullivan, Brian P, Prof, Freedman, Steven D, MD

“…Summary Cystic fibrosis is the most common lethal genetic disease in white populations. The outlook for patients with the disease has improved steadily over…”
Get full text

Practical guide to exocrine pancreatic insufficiency - Breaking the myths by Struyvenberg, Maarten R, Martin, Camilia R, Freedman, Steven D

“…Exocrine pancreatic insufficiency (EPI) is characterized by a deficiency of exocrine pancreatic enzymes, resulting in malabsorption. Numerous conditions…”
Get full text

Fat digestion using RELiZORB in children with short bowel syndrome who are dependent on parenteral nutrition: Protocol for a 90-day, phase 3, open labeled study by Tsikis, Savas T, Fligor, Scott C, Mitchell, Paul D, Hirsch, Thomas I, Carbeau, Sarah, First, Eric, Loring, Greta, Rudie, Coral, Freedman, Steven D, Martin, Camilia R, Gura, Kathleen M, Puder, Mark

“…Short bowel syndrome (SBS) is a leading cause of intestinal failure resulting in parenteral nutrition (PN) dependence and nutritional deficiencies. Long-term…”
Get full text

Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial by Nichols, David P, Paynter, Alex C, Heltshe, Sonya L, Donaldson, Scott H, Frederick, Carla A, Freedman, Steven D, Gelfond, Daniel, Hoffman, Lucas R, Kelly, Andrea, Narkewicz, Michael R, Pittman, Jessica E, Ratjen, Felix, Rosenfeld, Margaret, Sagel, Scott D, Schwarzenberg, Sarah Jane, Singh, Pradeep K, Solomon, George M, Stalvey, Michael S, Clancy, John P, Kirby, Shannon, Van Dalfsen, Jill M, Kloster, Margaret H, Rowe, Steven M

“…The cystic fibrosis (CF) modulator drug, elexacaftor/tezacaftor/ivacaftor (ETI), proved highly effective in controlled clinical trials for individuals with at…”
Get full text

Adipocytes promote ovarian cancer chemoresistance by Yang, Jiang, Zaman, Munir M., Vlasakov, Iliyan, Roy, Roopali, Huang, Lan, Martin, Camilia R., Freedman, Steven D., Serhan, Charles N., Moses, Marsha A.

“…Ovarian cancer (OvCa), while accounting for only 3% of all women’s cancer, is the fifth leading cause of cancer death among women. One of the most significant…”
Get full text

Validation of an omega-3 substrate challenge absorption test as an indicator of global fat lipolysis by Freedman, Steven D, Zaworski, Kamil, Pierzynowska, Kateryna, Pierzynowski, Stefan, Gallotto, Robert, Sathe, Meghana, Borowitz, Drucy S

“…The coefficient of fat absorption (CFA) quantifies fat that remains in stool after digestion and is not a direct measure of lipolysis. CFA has been used to…”
Get full text

Breast Milk Lipids and Fatty Acids in Regulating Neonatal Intestinal Development and Protecting against Intestinal Injury by Ramiro-Cortijo, David, Singh, Pratibha, Liu, Yan, Medina-Morales, Esli, Yakah, William, Freedman, Steven D, Martin, Camilia R

“…Human breast milk is the optimal source of nutrition for infant growth and development. Breast milk fats and their downstream derivatives of fatty acids and…”
Get full text

Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation by Freedman, Steven D

“…Patients with exocrine pancreatic insufficiency (EPI) have suboptimal secretion of pancreatic digestive enzymes and experience a range of clinical symptoms…”
Get full text

Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study in Patients With Cystic Fibrosis Receiving Enteral Feeding by Stevens, John, Wyatt, Colby, Brown, Perry, Patel, Dhiren, Grujic, Danica, Freedman, Steven D.

“…ABSTRACT Objectives: Pancreatic insufficiency (PI) and malabsorption of fats lead to reduced caloric intake, inability to maintain weight, and increased…”
Get full text

Update in Advancing the Gastrointestinal Frontier in Cystic Fibrosis by Vélez, Christopher, Freedman, Steven D., Assis, David N.

“…Clinical complications of cystic fibrosis (CF) include a variety of gastrointestinal (GI) and hepatobiliary manifestations. Recent years have witnessed several…”
Get full text

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors by KROP, Ian, DEMUTH, Tim, BLACKMAN, Samuel, WATTERS, James, LOBODA, Andrey, PODTELEZHNIKOV, Alexei, LUNCEFORD, Jared, CONG CHEN, GIANNOTTI, Maxine, HING, Jeremy, BECKMAN, Robert, LORUSSO, Patricia, GUTHRIE, Tina, WEN, Patrick Y, MASON, Warren P, CHINNAIYAN, Prakash, BUTOWSKI, Nicholas, GROVES, Morris D, KESARI, Santosh, FREEDMAN, Steven J

“…Aberrant Notch signaling has been implicated in the pathogenesis of many human cancers. MK-0752 is a potent, oral inhibitor of γ-secretase, an enzyme required…”
Get full text

Need to study simplification of gastrointestinal medication regimen in cystic fibrosis in the era of highly effective modulators by Sathe, Meghana, Moshiree, Baha, Aliaj, Enid, Lee, MinJae, Hudson, Jessica, Gifford, Alex, Attel, Susan, Gamel, Breck, Freedman, Steven D., Schwarzenberg, Sarah Jane, Freeman, A. Jay

“…Introduction The success of highly effective modulator therapy (HEMT) has led to consideration of simpler regimens for people with CF (PwCF) with opportunities…”
Get full text

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation by Giles, Francis J., Cortes, Jorge, Jones, Dan, Bergstrom, Donald, Kantarjian, Hagop, Freedman, Steven J.

“…MK-0457 (VX-680) is a small-molecule aurora kinase (AK) inhibitor with preclinical antileukemia activity. The T315I BCR-ABL mutation mediates resistance to…”
Get full text

Racial and Ethnic Disparities in Opioid Prescriptions in Benign and Malignant Pancreatic Disease in the United States by McHenry, Nicole, Ahmed, Awais, Shah, Ishani, Freedman, Steven D., Nee, Judy, Lembo, Anthony, Sheth, Sunil G.

“…Racial-ethnic disparities in pain management are common but not known among pancreatic disease patients. We sought to evaluate racial-ethnic disparities in…”
Get full text

Prospective Evaluation of Sexual Dysfunction in Men With Chronic Pancreatitis: A Pilot Study by Shah, Ishani, Anderson, Kelsey, Bocchino, Rachel, Freedman, Steven D, Carrasquillo, Robert, Sheth, Sunil G

“…Our study aimed to determine the prevalence of sexual dysfunction (SD) and its association with quality of life (QOL) in men with chronic pancreatitis (CP)…”
Get more information

Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices by Morinville, Veronique D., Husain, Sohail Z., Bai, Harrison, Barth, Bradley, Alhosh, Rabea, Durie, Peter R., Freedman, Steven D., Himes, Ryan, Lowe, Mark E., Pohl, John, Werlin, Steven, Wilschanski, Michael, Uc, Aliye

“…ABSTRACT Objectives: There is limited literature on acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) in children. The…”
Get full text

Pediatric Chronic Pancreatitis Is Associated with Genetic Risk Factors and Substantial Disease Burden by Schwarzenberg, Sarah Jane, MD, Bellin, Melena, MD, Husain, Sohail Z., MD, Ahuja, Monika, MCA, Barth, Bradley, MD, Davis, Heather, MD, Durie, Peter R., MD, Fishman, Douglas S., MD, Freedman, Steven D., MD, Gariepy, Cheryl E., MD, Giefer, Matthew J., MD, Gonska, Tanja, MD, Heyman, Melvin B., MD, MPH, Himes, Ryan, MD, Kumar, Soma, MD, Morinville, Veronique D., MD, Lowe, Mark E., MD, PhD, Nuehring, Neil E., BS, Ooi, Chee Y., MD, Pohl, John F., MD, Troendle, David, MD, Werlin, Steven L., MD, Wilschanski, Michael, MD, Yen, Elizabeth, MD, Uc, Aliye, MD

“…Objective To determine the clinical presentation, diagnostic variables, risk factors, and disease burden in children with chronic pancreatitis. Study design We…”
Get full text

Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury by Martin, Camilia R, Zaman, Munir M, Gilkey, Calvin, Salguero, Maria V, Hasturk, Hatice, Kantarci, Alpdogan, Van Dyke, Thomas E, Freedman, Steven D

“…The critical fatty acids Docosahexaenoic Acid (DHA) and Arachidonic Acid (AA) decline in preterm infants within the first postnatal week and are associated…”
Get full text

Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE by Kumar, Soma, Ooi, Chee Y, Werlin, Steven, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D, Durie, Peter R, Fishman, Douglas S, Freedman, Steven D, Gariepy, Cheryl, Giefer, Matthew J, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan, Husain, Sohail Z, Lin, Tom K, Lowe, Mark E, Morinville, Veronique, Palermo, Joseph J, Pohl, John F, Schwarzenberg, Sarah Jane, Troendle, David, Wilschanski, Michael, Zimmerman, M Bridget, Uc, Aliye

“…Pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood. To characterize and identify risk factors associated with ARP…”
Get more information