Search Results - "FREEDMAN, Jane E"

Circulating Extracellular Vesicles in Human Disease by Shah, Ravi, Patel, Tushar, Freedman, Jane E

“…Circulating extracellular vesicles, which are produced by normal and diseased tissues and released into body fluids, can be markers of disease processes and…”
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Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis by Koupenova, Milka, Clancy, Lauren, Corkrey, Heather A, Freedman, Jane E

“…Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The…”
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Oxidative Stress and Platelets by Freedman, Jane E

“…Platelet-dependent thrombus formation may be influenced by alteration of platelet or vascular redox state, the presence of endogenous or exogenous…”
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MicroRNAs in platelet function and cardiovascular disease by McManus, David D., Freedman, Jane E.

“…Key Points Platelet function has an important role in mediating particular common forms of cardiovascular disease, such as acute coronary syndromes and stroke…”
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SARS-CoV-2 Initiates Programmed Cell Death in Platelets by Koupenova, Milka, Corkrey, Heather A., Vitseva, Olga, Tanriverdi, Kahraman, Somasundaran, Mohan, Liu, Ping, Soofi, Shaukat, Bhandari, Rohan, Godwin, Matthew, Parsi, Krishna Mohan, Cousineau, Alyssa, Maehr, René, Wang, Jennifer P., Cameron, Scott J., Rade, Jeffrey, Finberg, Robert W., Freedman, Jane E.

“…[Figure: see text]…”
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The role of platelets in mediating a response to human influenza infection by Koupenova, Milka, Corkrey, Heather A., Vitseva, Olga, Manni, Giorgia, Pang, Catherine J., Clancy, Lauren, Yao, Chen, Rade, Jeffrey, Levy, Daniel, Wang, Jennifer P., Finberg, Robert W., Kurt-Jones, Evelyn A., Freedman, Jane E.

“…Influenza infection increases the incidence of myocardial infarction but the reason is unknown. Platelets mediate vascular occlusion through thrombotic…”
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Platelets and platelet-like particles mediate intercellular RNA transfer by Risitano, Antonina, Beaulieu, Lea M., Vitseva, Olga, Freedman, Jane E.

“…The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways…”
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Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis by Koupenova, Milka, Vitseva, Olga, MacKay, Christopher R., Beaulieu, Lea M., Benjamin, Emelia J., Mick, Eric, Kurt-Jones, Evelyn A., Ravid, Katya, Freedman, Jane E.

“…Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection…”
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Diverse human extracellular RNAs are widely detected in human plasma by Freedman, Jane E., Gerstein, Mark, Mick, Eric, Rozowsky, Joel, Levy, Daniel, Kitchen, Robert, Das, Saumya, Shah, Ravi, Danielson, Kirsty, Beaulieu, Lea, Navarro, Fabio C. P., Wang, Yaoyu, Galeev, Timur R., Holman, Alex, Kwong, Raymond Y., Murthy, Venkatesh, Tanriverdi, Selim E., Koupenova, Milka, Mikhalev, Ekaterina, Tanriverdi, Kahraman

“…There is growing appreciation for the importance of non-protein-coding genes in development and disease. Although much is known about microRNAs, limitations in…”
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Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer by McAnena, Peter, Tanriverdi, Kahraman, Curran, Catherine, Gilligan, K, Freedman, Jane E, Brown, James A L, Kerin, Michael J

“…Breast cancer is the leading cause of cancer related death in women, with metastasis the principle cause of mortality. New non-invasive prognostic markers are…”
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Genome-wide identification of microRNA expression quantitative trait loci by Huan, Tianxiao, Rong, Jian, Liu, Chunyu, Zhang, Xiaoling, Tanriverdi, Kahraman, Joehanes, Roby, Chen, Brian H., Murabito, Joanne M., Yao, Chen, Courchesne, Paul, Munson, Peter J., O’Donnell, Christopher J., Cox, Nancy, Johnson, Andrew D., Larson, Martin G., Levy, Daniel, Freedman, Jane E.

“…Identification of microRNA expression quantitative trait loci (miR-eQTL) can yield insights into regulatory mechanisms of microRNA transcription, and can help…”
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Attomolar sensitivity microRNA detection using real-time digital microarrays by Ekiz Kanik, Fulya, Celebi, Iris, Sevenler, Derin, Tanriverdi, Kahraman, Lortlar Ünlü, Nese, Freedman, Jane E., Ünlü, M. Selim

“…MicroRNAs (miRNAs) are a family of noncoding, functional RNAs. With recent developments in molecular biology, miRNA detection has attracted significant…”
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Stroke and Circulating Extracellular RNAs by Mick, Eric, Shah, Ravi, Tanriverdi, Kahraman, Murthy, Venkatesh, Gerstein, Mark, Rozowsky, Joel, Kitchen, Robert, Larson, Martin G, Levy, Daniel, Freedman, Jane E

“…BACKGROUND AND PURPOSE—There is increasing interest in extracellular RNAs (ex-RNAs), with numerous reports of associations between selected microRNAs (miRNAs)…”
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Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase by Blair, Price, Rex, Sybille, Vitseva, Olga, Beaulieu, Lea, Tanriverdi, Kahraman, Chakrabarti, Subrata, Hayashi, Chie, Genco, Caroline A, Iafrati, Mark, Freedman, Jane E

“…Cells of the innate immune system use Toll-like receptors (TLRs) to initiate the proinflammatory response to microbial infection. Recent studies have shown…”
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Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study by Vaze, Aditya, Tran, Khanh-Van, Tanriverdi, Kahraman, Sardana, Mayank, Lessard, Darleen, Donahue, J Kevin, Barton, Bruce, Aurigemma, Gerard, Lubitz, Steven A, Lin, Honghuang, Nasr, George H, Mandapati, Amiya, Benjamin, Emelia J, Vasan, Ramachandran S, Freedman, Jane E, McManus, David D

“…Circulating microRNAs may reflect or influence pathological cardiac remodeling and contribute to atrial fibrillation (AF). The purpose of this study was to…”
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Regulatory effects of TLR2 on megakaryocytic cell function by Beaulieu, Lea M., Lin, Elaine, Morin, Kristine M., Tanriverdi, Kahraman, Freedman, Jane E.

“…TLR2, a functional, inflammatory-related receptor, is known to be expressed on megakaryocytes and platelets and to lead to infection and immune-mediated…”
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CD40–CD40 ligand interactions in oxidative stress, inflammation and vascular disease by Rizvi, Muhammad, Pathak, Didi, Freedman, Jane E, Chakrabarti, Subrata

“…CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways that contribute to multiple pathophysiological processes. A role for…”
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Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study by McManus, David D., MD, MSc, FHRS, Lin, Honghuang, PhD, Tanriverdi, Kahraman, PhD, Quercio, Michael, MS, Yin, Xiaoyan, PhD, Larson, Martin G., SD, Ellinor, Patrick T., MD, PhD, FHRS, Levy, Daniel, MD, Freedman, Jane E., MD, Benjamin, Emelia J., MD, MSc

“…Background MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how…”
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Atrial natriuretic peptide is negatively regulated by microRNA-425 by Arora, Pankaj, Wu, Connie, Khan, Abigail May, Bloch, Donald B, Davis-Dusenbery, Brandi N, Ghorbani, Anahita, Spagnolli, Ester, Martinez, Andrew, Ryan, Allicia, Tainsh, Laurel T, Kim, Samuel, Rong, Jian, Huan, Tianxiao, Freedman, Jane E, Levy, Daniel, Miller, Karen K, Hata, Akiko, Del Monte, Federica, Vandenwijngaert, Sara, Swinnen, Melissa, Janssens, Stefan, Holmes, Tara M, Buys, Emmanuel S, Bloch, Kenneth D, Newton-Cheh, Christopher, Wang, Thomas J

“…Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the…”
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Gene expression signatures of coronary heart disease by Joehanes, Roby, Ying, Saixia, Huan, Tianxiao, Johnson, Andrew D, Raghavachari, Nalini, Wang, Richard, Liu, Poching, Woodhouse, Kimberly A, Sen, Shurjo K, Tanriverdi, Kahraman, Courchesne, Paul, Freedman, Jane E, O'Donnell, Christopher J, Levy, Daniel, Munson, Peter J

“…To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the…”
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