Search Results - "FREEDMAN, J."

Posterior parietal cortex plays a causal role in perceptual and categorical decisions by Zhou, Yang, Freedman, David J

“…Posterior parietal cortex (PPC) activity correlates with monkeys' decisions during visual discrimination and categorization tasks. However, recent work has…”
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An Integrative Framework for Sensory, Motor, and Cognitive Functions of the Posterior Parietal Cortex by Freedman, David J., Ibos, Guilhem

“…Throughout the history of modern neuroscience, the parietal cortex has been associated with a wide array of sensory, motor, and cognitive functions. The use of…”
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Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization by Masse, Nicolas Y., Grant, Gregory D., Freedman, David J.

“…Humans and most animals can learn new tasks without forgetting old ones. However, training artificial neural networks (ANNs) on new tasks typically causes them…”
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Neuronal Mechanisms of Visual Categorization: An Abstract View on Decision Making by Freedman, David J, Assad, John A

“…Categorization is our ability to flexibly assign sensory stimuli into discrete, behaviorally relevant groupings. Categorical decisions can be used to study…”
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A hierarchy of intrinsic timescales across primate cortex by Murray, John D, Bernacchia, Alberto, Freedman, David J, Romo, Ranulfo, Wallis, Jonathan D, Cai, Xinying, Padoa-Schioppa, Camillo, Pasternak, Tatiana, Seo, Hyojung, Lee, Daeyeol, Wang, Xiao-Jing

“…Primate cortex can be organized with specialization and hierarchical principles, but presently there is little evidence for how it is organized temporally…”
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Circuit mechanisms for the maintenance and manipulation of information in working memory by Masse, Nicolas Y., Yang, Guangyu R., Song, H. Francis, Wang, Xiao-Jing, Freedman, David J.

“…Recently it has been proposed that information in working memory (WM) may not always be stored in persistent neuronal activity but can be maintained in…”
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Computing by Robust Transience: How the Fronto-Parietal Network Performs Sequential, Category-Based Decisions by Chaisangmongkon, Warasinee, Swaminathan, Sruthi K., Freedman, David J., Wang, Xiao-Jing

“…Decision making involves dynamic interplay between internal judgements and external perception, which has been investigated in delayed match-to-category (DMC)…”
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Low-dimensional encoding of decisions in parietal cortex reflects long-term training history by Latimer, Kenneth W., Freedman, David J.

“…Neurons in parietal cortex exhibit task-related activity during decision-making tasks. However, it remains unclear how long-term training to perform different…”
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Dynamic Integration of Task-Relevant Visual Features in Posterior Parietal Cortex by Ibos, Guilhem, Freedman, David J.

“…The primate visual system consists of multiple hierarchically organized cortical areas, each specialized for processing distinct aspects of the visual scene…”
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Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping by Freedman, Kevin J., Otto, Lauren M., Ivanov, Aleksandar P., Barik, Avijit, Oh, Sang-Hyun, Edel, Joshua B.

“…Single-molecule techniques are being developed with the exciting prospect of revolutionizing the healthcare industry by generating vast amounts of genetic and…”
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Nonlinear mixed selectivity supports reliable neural computation by Johnston, W Jeffrey, Palmer, Stephanie E, Freedman, David J

“…Neuronal activity in the brain is variable, yet both perception and behavior are generally reliable. How does the brain achieve this? Here, we show that the…”
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Nanopore Current Enhancements Lack Protein Charge Dependence and Elucidate Maximum Unfolding at Protein’s Isoelectric Point by Bandara, Y. M. Nuwan D. Y, Farajpour, Nasim, Freedman, Kevin J

“…Protein sequencing, as well as protein fingerprinting, has gained tremendous attention in the electrical sensing realm of solid-state nanopores and is…”
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Gold Nanoparticle Translocation Dynamics and Electrical Detection of Single Particle Diffusion Using Solid-State Nanopores by Goyal, Gaurav, Freedman, Kevin J, Kim, Min Jun

“…This paper describes the use of gold nanoparticles to study particle translocation dynamics through silicon nitride solid-state nanopores. Gold nanoparticles…”
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Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field by Freedman, Kevin J., Haq, S. Raza, Edel, Joshua B., Jemth, Per, Kim, Min Jun

“…Single molecule methods have provided a significantly new look at the behavior of biomolecules in both equilibrium and non-equilibrium conditions. Most notable…”
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A proposed common neural mechanism for categorization and perceptual decisions by Freedman, David J, Assad, John A

“…Parietal cortex has been implicated as a locus for decision making, and it has been suggested that decision encoding in this area is based on the movement used…”
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Nanodiagnostics: A review of the medical capabilities of nanopores by Lastra, Lauren S., Sharma, Vinay, Farajpour, Nasim, Nguyen, Michelle, Freedman, Kevin J.

“…Modern diagnostics strive to be accurate, fast, and inexpensive in addition to properly identifying the presence of a disease, infection, or illness. Early…”
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On the origins of conductive pulse sensing inside a nanopore by Lastra, Lauren S., Bandara, Y. M. Nuwan D. Y., Nguyen, Michelle, Farajpour, Nasim, Freedman, Kevin J.

“…Nanopore sensing is nearly synonymous with resistive pulse sensing due to the characteristic occlusion of ions during pore occupancy, particularly at high salt…”
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Independent Category and Spatial Encoding in Parietal Cortex by Rishel, Chris A., Huang, Gang, Freedman, David J.

“…The posterior parietal cortex plays a central role in spatial functions, such as spatial attention and saccadic eye movements. However, recent work has…”
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Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors by KROP, Ian, DEMUTH, Tim, BLACKMAN, Samuel, WATTERS, James, LOBODA, Andrey, PODTELEZHNIKOV, Alexei, LUNCEFORD, Jared, CONG CHEN, GIANNOTTI, Maxine, HING, Jeremy, BECKMAN, Robert, LORUSSO, Patricia, GUTHRIE, Tina, WEN, Patrick Y, MASON, Warren P, CHINNAIYAN, Prakash, BUTOWSKI, Nicholas, GROVES, Morris D, KESARI, Santosh, FREEDMAN, Steven J

“…Aberrant Notch signaling has been implicated in the pathogenesis of many human cancers. MK-0752 is a potent, oral inhibitor of γ-secretase, an enzyme required…”
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Task dependence of visual and category representations in prefrontal and inferior temporal cortices by McKee, Jillian L, Riesenhuber, Maximilian, Miller, Earl K, Freedman, David J

“…Visual categorization is an essential perceptual and cognitive process for assigning behavioral significance to incoming stimuli. Categorization depends on…”
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