Search Results - "FREEDBERG, I M"

Rays and arrays: the transcriptional program in the response of human epidermal keratinocytes to UVB illumination by Li, Deling, Turi, Thomas G., Schuck, Alyssa, Freedberg, Irwin M., Khitrov, Gregory, Blumenberg, Miroslav

“…ABSTRACT The epidermis, our first line of defense from ultraviolet (UV) light, bears the majority of photodamage, which results in skin thinning, wrinkling,…”
Get full text

Epidermal Growth Factor and Transforming Growth Factor α Specifically Induce the Activation- and Hyperproliferation-Associated Keratins 6 and 16 by C.-K. Jiang, Magnaldo, T., Ohtsuki, M., Freedberg, I. M., Bernerd, F., Blumenberg, M.

“…Epidermal injury results in activation of keratinocytes which produce and respond to growth factors and cytokines and become migratory. Activated keratinocytes…”
Get full text

Disease-activated transcription factor: allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17 by Jiang, C K, Flanagan, S, Ohtsuki, M, Shuai, K, Freedberg, I M, Blumenberg, M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Keratins and the Keratinocyte Activation Cycle by Freedberg, Irwin M., Tomic-Canic, Marjana, Komine, Mayumi, Blumenberg, Miroslav

“…In wound healing and many pathologic conditions, keratinocytes become activated: they turn into migratory, hyperproliferative cells that produce and secrete…”
Get full text

Specific Organization of the Negative Response Elements for Retinoic Acid and Thyroid Hormone Receptors in Keratin Gene Family by Radoja, Nadezda, Diaz, Danilo V., Minars, Todd J., Freedberg, Irwin M., Blumenberg, Miroslav, Tomic-Canic, Marjana

“…Retinoic acid and thyroid hormone are important regulators of epidermal growth, differentiation, and homeostasis. Retinoic acid is extensively used in the…”
Get full text

The dermatology-industry interface: Defining the boundaries by Sams, W.Mitchell, Freedberg, Irwin M.

“…Support from industry has become an important factor in the growth of the dermatologic profession. However, the relationship creates inevitable conflicts of…”
Get full text

Embryonic expression of the human 40-kD keratin: evidence from a processed pseudogene sequence by SAVTCHENKO, E. S, SCHIFF, T. A, JIANG, C.-K, FREEDBERG, I. M, BLUMENBERG, M

“…Analysis of the cytoskeletal components of early murine embryos has detected expression of two keratin proteins, K#8 and K#18, at the 4-8-cell stage…”
Get full text

Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes by Tomic, M, Jiang, C K, Epstein, H S, Freedberg, I M, Samuels, H H, Blumenberg, M

“…In the epidermis, retinoids regulate the expression of keratins, the intermediate filament proteins of epithelial cells. We have cloned the 5' regulatory…”
Get full text

Close Linkage of the Two Keratin Gene Clusters in the Human Genome by Milisavljevic, Vladana, Freedberg, Irwin M., Blumenberg, Miroslav

“…Mapping studies of functional keratin genes in the human genome have localized most of the acidic keratin genes to chromosome 17q12–q21 and the basic keratin…”
Get full text

Regulation of Keratin Gene Expression: The Role of the Nuclear Receptors for Retinoic Acid, Thyroid Hormone, and Vitamin D3 by Blumenberg, Miroslav, Connolly, Deirdre M, Freedberg, Irwin M

“…Keratinization, the orderly process of differentiation of epidermal keratinocytes from stratum basale to stratum corneum, is influenced by hormones and…”
Get full text

Identification of the Retinoic Acid and Thyroid Hormone Receptor-Responsive Element in the Human K14 Keratin Gene by Tomic-Canic, Marjana, Sunjevaric, Ivana, Freedberg, Irwin M, Blumenberg, Miroslav

“…The promoter of human K14 keratin gene, specific for the basal layer of stratified epithelia, is regulated by nuclear receptors for retinoic acid and thyroid…”
Get full text

Inpatient dermatology: should we let it die or should we work towards regional centers? by Kirsner, R S, Freedberg, I M, Kerdel, F A

Get full text

Epithelial-specific keratin gene expression : identification of a 300 base-pair controlling segment by JIANG, C.-K, EPSTEIN, H. S, TOMIC, M, FREEDBERG, I. M, BLUMENBERG, M

“…To elucidate the elements required for regulation of keratin expression in epidermis, we have linked a short, 300 base pair segment, corresponding to the…”
Get full text

Nuclear Proteins Involved in Transcription of the Human K5 Keratin Gene by Ohtsuki, Mamitaro, Tomic-Canic, Marjana, Freedberg, Irwin M., Blumenberg, Miroslav

“…Keratin K5 is expressed in the basal layer of stratified epithelia in mammals and its synthesis is regulated by hormones and vitamins such as retinoic acid…”
Get full text

Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes by Komine, Mayumi, Rao, Laxmi S., Freedberg, Irwin M., Simon, Marcia, Milisavljevic, Vladana, Blumenberg, Miroslav

“…Keratinocytes respond to injury by releasing the proinflammatory cytokine interleukin-1, which serves as the initial ‘‘alarm signal’' to surrounding cells…”
Get full text

The Use of Monoclonal Antibody to Keratin in Human Epidermal Disease: Alterations in Immunohistochemical Staining Pattern by Weiss, Robert A., Guillet, Gerard Y.A., Freedberg, Irwin M., Farmer, Evan R., Small, Elizabeth A., Weiss, Margaret M., Sun, Tung-Tien

“…A monoclonal antikeratin antibody, designated AE1, was used to stain frozen sections of normal and abnormal human skin by the immunofluorescence and…”
Get full text

Molecular effects of T lymphocytes on the regulation of keratin gene expression by Flanagan, S, Ohtsuki, M, Freedberg, I M, Blumenberg, M, Perelman, R O

“…The interactions between lymphocytes and the epidermis are very important in autoimmune skin diseases. Mutual interaction between keratinocytes and T cells is…”
Get more information

Retinoid hepatitis by Sanchez, M R, Ross, B, Rotterdam, H, Salik, J, Brodie, R, Freedberg, I M

“…A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months…”
Get more information

Transcriptional control of K5, K6, K14, and K17 keratin genes by AP-1 and NF-kappaB family members by Ma, S, Rao, L, Freedberg, I M, Blumenberg, M

“…The expression of keratins K5 and K14 is restricted to the basal layers of the healthy epidermis, whereas the expression of K6 and K17 is induced in response…”
Get full text

Epidermal signal transduction and transcription factor activation in activated keratinocytes by Tomic-Canic, Marjana, Komine, Mayumi, Freedberg, Irwin M, Blumenberg, Miroslav

“…In the area of biology, many laboratories around the world are dissecting and characterizing signal transduction mechanisms and transcription factors…”
Get full text