Search Results - "FREDRIX, Hanny"

PD-L1 siRNA-mediated silencing in acute myeloid leukemia enhances anti-leukemic T cell reactivity by van Ens, Diede, Mousset, Charlotte M., Hutten, Tim J. A., van der Waart, Anniek B., Campillo-Davo, Diana, van der Heijden, Sanne, Vodegel, Denise, Fredrix, Hanny, Woestenenk, Rob, Parga-Vidal, Loreto, Jansen, Joop H., Schaap, Nicolaas P. M., Lion, Eva, Dolstra, Harry, Hobo, Willemijn

“…Acute myeloid leukemia (AML) is an immune-susceptible malignancy, as demonstrated by its responsiveness to allogeneic stem cell transplantation (alloSCT)…”
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Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy by Mousset, Charlotte M., Hobo, Willemijn, Ji, Yun, Fredrix, Hanny, De Giorgi, Valeria, Allison, Robert D., Kester, Michel G. D., Falkenburg, J. H. Frederik, Schaap, Nicolaas P. M., Jansen, Joop H., Gattinoni, Luca, Dolstra, Harry, van der Waart, Anniek B.

“…Adoptive T cell therapy has shown clinical potential for patients with cancer, though effective treatment is dependent on longevity and potency of the…”
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A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR by Broen, Kelly, Levenga, Henriette, Vos, Johanna, van Bergen, Kees, Fredrix, Hanny, Greupink-Draaisma, Annelies, Kester, Michel, Falkenburg, J H Frederik, de Mulder, Pieter, de Witte, Theo, Griffioen, Marieke, Dolstra, Harry

“…Nonmyeloablative allogeneic stem cell transplantation (SCT) can induce remission in patients with renal cell carcinoma (RCC), but this graft-versus-tumor (GVT)…”
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A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia by Dolstra, H, Fredrix, H, Maas, F, Coulie, P G, Brasseur, F, Mensink, E, Adema, G J, de Witte, T M, Figdor, C G, van de Wiel-van Kemenade, E

“…Human minor histocompatibility antigens (mHags) play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human…”
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Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation by Hobo, Willemijn, Novobrantseva, Tatiana I., Fredrix, Hanny, Wong, Jamie, Milstein, Stuart, Epstein-Barash, Hila, Liu, Ju, Schaap, Nicolaas, van der Voort, Robbert, Dolstra, Harry

“…Dendritic cell (DC)-based vaccination boosting antigen-specific immunity is being explored for the treatment of cancer and chronic viral infections. Although…”
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siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8+ T cells in NOD/SCID/IL2Rg(null) mice by van der Waart, Anniek B., Fredrix, Hanny, van der Voort, Robbert, Schaap, Nicolaas, Hobo, Willemijn, Dolstra, Harry

“…Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is…”
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Immunogenicity of dendritic cells pulsed with MAGE3, Survivin and B-cell maturation antigen mRNA for vaccination of multiple myeloma patients by Hobo, Willemijn, Strobbe, Leonie, Maas, Frans, Fredrix, Hanny, Greupink-Draaisma, Annelies, Esendam, Ben, de Witte, Theo, Preijers, Frank, Levenga, Henriëtte, van Rees, Bas, Raymakers, Reinier, Schaap, Nicolaas, Dolstra, Harry

“…The introduction of autologous stem cell transplantation (SCT) and novel drugs has improved overall survival in multiple myeloma (MM) patients. However,…”
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CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses by Hutten, Tim J A, Thordardottir, Soley, Fredrix, Hanny, Janssen, Lisanne, Woestenenk, Rob, Tel, Jurjen, Joosten, Ben, Cambi, Alessandra, Heemskerk, Mirjam H M, Franssen, Gerben M, Boerman, Otto C, Bakker, Lex B H, Jansen, Joop H, Schaap, Nicolaas, Dolstra, Harry, Hobo, Willemijn

“…Potent immunotherapies are urgently needed to boost antitumor immunity and control disease in cancer patients. As dendritic cells (DCs) are the most powerful…”
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B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation by Hobo, Willemijn, Norde, Wieger J, Schaap, Nicolaas, Fredrix, Hanny, Maas, Frans, Schellens, Karen, Falkenburg, J H Frederik, Korman, Alan J, Olive, Daniel, van der Voort, Robbert, Dolstra, Harry

“…Allogeneic stem cell transplantation (allo-SCT) can cure hematological malignancies by inducing alloreactive T cell responses targeting minor…”
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Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the cationic lipid SAINT-18 by Roeven, Mieke W H, Hobo, Willemijn, van der Voort, Robbert, Fredrix, Hanny, Norde, Wieger J, Teijgeler, Kasper, Ruiters, Marcel H J, Schaap, Nicolaas, Dolstra, Harry

“…Dendritic cell (DC)-based vaccination is an appealing strategy to boost graft-versus-tumor immunity after allogeneic stem cell transplantation (allo-SCT), and…”
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siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8 super(+) T cells in NOD/SCID/IL2Rg(null) mice by van der Waart, Anniek B, Fredrix, Hanny, van der Voort, Robbert, Schaap, Nicolaas, Hobo, Willemijn, Dolstra, Harry

“…Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is…”
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siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8^sup +^ T cells in NOD/SCID/IL2Rg(null) mice by van der Waart, Anniek B, Fredrix, Hanny, van der Voort, Robbert, Schaap, Nicolaas, Hobo, Willemijn, Dolstra, Harry

“…Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is…”
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Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells by Norde, Wieger J., Overes, Ingrid M., Maas, Frans, Fredrix, Hanny, Vos, Johanna C.M., Kester, Michel G.D., van der Voort, Robbert, Jedema, Inge, Falkenburg, J. H. Frederik, Schattenberg, Anton V., de Witte, Theo M., Dolstra, Harry

“…CD8+ T cells recognizing minor histocompatibility antigens (MiHAs) on leukemic stem and progenitor cells play a pivotal role in effective graft-versus-leukemia…”
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Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation by Hobo, Willemijn, Broen, Kelly, van der Velden, Walter J.F.M., Greupink-Draaisma, Annelies, Adisty, Niken, Wouters, Yannick, Kester, Michel G.D., Fredrix, Hanny, Jansen, Joop H., van der Reijden, Bert A., Falkenburg, J.H. Frederik, de Witte, Theo, Preijers, Frank W.M.B., Schattenberg, Anton, Feuth, Ton, Blijlevens, Nicole N.A., Schaap, Nicolaas, Dolstra, Harry

“…Abstract 4136 Allogeneic stem cell transplantation (allo-SCT) can induce remission in patients with hematological malignancies due to graft-versus-tumor (GVT)…”
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Expression of P2X5 in lymphoid malignancies results in LRH‐1‐specific cytotoxic T‐cell‐mediated lysis by Overes, Ingrid M., De Rijke, Björn, Van Horssen‐Zoetbrood, Agnes, Fredrix, Hanny, De Graaf, Aniek O., Jansen, Joop H., Van Krieken, J. Han J. M., Raymakers, Reinier A. P., Van Der Voort, Robbert, De Witte, Theo M., Dolstra, Harry

“…Summary Minor histocompatibility antigens (MiHA) selectively expressed by haematopoietic cells are attractive targets for specific immunotherapy after…”
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Efficient Activation of LRH-1―specific CD8+ T-cell Responses From Transplanted Leukemia Patients by Stimulation With P2X5 mRNA-electroporated Dendritic Cells by OVERES, Ingrid M, FREDRIX, Hanny, KESTER, Michel G. D, FREDERIK FALKENBURG, J. H, VAN DER VOORT, Robbert, DE WITTE, Theo M, DOLSTRA, Harry

“…Alloreactive CD8+ T cells targeting minor histocompatibility antigens (MiHA) on malignant cells of the recipient play a pivotal role in graft-versus-tumor…”
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Use of RNA Electroporated DC for Activation of LRH-1 Specific Cytotoxic T Lymphocytes in the Treatment of Lymphoid Malignancies by Overes, Ingrid, Fredrix, Hanny, de Rijke, Bjorn, van Horssen-Zoetbrood, Agnes, van Krieken, Han, Raymakers, Reinier, van der Voort, Robbert, de Witte, T.M., Dolstra, Harry

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is a potent treatment for patients with hematological malignancies. The therapeutic efficacy is…”
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Bi‐directional allelic recognition of the human minor histocompatibility antigen HB‐1 by cytotoxic T lymphocytes by Dolstra, Harry, Rijke, Björn de, Fredrix, Hanny, Balas, Antonio, Maas, Frans, Scherpen, Frank, Aviles, Maria J., Vicario, Jose L., Beekman, Nico J., Ossendorp, Ferry, Witte, Theo M. de, Kemenade, Elly van de Wiel‐van

“…Human minor histocompatibility antigens (mHag) are target antigens of the graft‐versus‐leukemia response observed after allogeneic HLA‐identical stem cell…”
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Refinement of molecular approaches to improve the chance of identification of hematopoietic-restricted minor histocompatibility antigens by de Rijke, Björn, van Horssen-Zoetbrood, Agnes, Veenbergen, Sharon, Fredrix, Hanny, de Witte, Theo, van de Wiel-van Kemenade, Elly, Dolstra, Harry

“…Minor histocompatibility antigens (mHAgs) constitute the target antigens of the T cell-mediated graft-versus-leukemia response after HLA-identical allogeneic…”
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Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL by Dolstra, H, Fredrix, H, Preijers, F, Goulmy, E, Figdor, CG, de Witte, TM, van de Wiel-van Kemenade, E

“…CTL directed against minor histocompatibility Ags (mHag) play a major role in antileukemia reactivity after HLA-identical bone marrow transplantation. Some of…”
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