Search Results - "FREDRIKSON, Gunilla Nordin"

Apolipoprotein B100 autoimmunity and atherosclerosis - disease mechanisms and therapeutic potential by Nilsson, Jan, Björkbacka, Harry, Fredrikson, Gunilla Nordin

“…Adaptive immune responses have been shown to play an important role in the atherosclerotic disease process and both pathogenic and protective immunity has been…”
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IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice by Mantani, Polyxeni T, Dunér, Pontus, Bengtsson, Eva, Alm, Ragnar, Ljungcrantz, Irena, Söderberg, Ingrid, Sundius, Lena, To, Fong, Nilsson, Jan, Björkbacka, Harry, Fredrikson, Gunilla Nordin

“…IL-25 has been implicated in the initiation of type 2 immunity and in the protection against autoimmune inflammatory diseases. Recent studies have identified…”
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Recombinant Antibodies to an Oxidized Low-Density Lipoprotein Epitope Induce Rapid Regression of Atherosclerosis in Apobec-1−/− /Low-Density Lipoprotein Receptor−/− Mice by Schiopu, Alexandru, MD, PhD, Frendéus, Björn, PhD, Jansson, Bo, PhD, Söderberg, Ingrid, BSI, Ljungcrantz, Irena, BSI, Araya, Zufan, PhD, Shah, Prediman K., MD, FACC, Carlsson, Roland, PhD, Nilsson, Jan, MD, PhD, Fredrikson, Gunilla Nordin, PhD

“…Recombinant Antibodies to an Oxidized Low-Density Lipoprotein Epitope Induce Rapid Regression of Atherosclerosis in Apobec-1−/− /Low-Density Lipoprotein…”
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A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer by Wendel, Ulrika, Persson, Nina, Risinger, Christian, Bengtsson, Eva, Nodin, Björn, Danielsson, Lena, Welinder, Charlotte, Nordin Fredrikson, Gunilla, Jansson, Bo, Blixt, Ola

“…Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations…”
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Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women by Fagerberg, Björn, Prahl Gullberg, Ulrica, Alm, Ragnar, Nilsson, Jan, Fredrikson, Gunilla Nordin

“…Immune responses against oxidized low density lipoprotein (LDL) play a key role in atherosclerosis. Previous studies have indicated inverse associations…”
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TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice by Kolbus, Daniel, Ljungcrantz, Irena, Söderberg, Ingrid, Alm, Ragnar, Björkbacka, Harry, Nilsson, Jan, Fredrikson, Gunilla Nordin

“…Antigen presenting cells (APC) have the ability to present both extra-cellular and intra-cellular antigens via MHC class I molecules to CD8(+) T cells. The…”
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Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: A potential link to fatty acid-induced insulin resistance by RISERUS, Ulf, BASU, Samar, JOVINGE, Stefan, FREDRIKSON, Gunilla Nordin, ÄRNLÖV, Johan, VESSBY, Bengt

“…Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we…”
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Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis by SCHIOPU, Alexandru, BENGTSSON, Jenny, SÖDERBERG, Ingrid, JANCIAUSKIENE, Sabina, LINDGREN, Stefan, ARES, Mikko P. S, SHAH, Prediman K, CARLSSON, Roland, NILSSON, Jan, FREDRIKSON, Gunilla Nordin

“…Accumulation and oxidation of LDL are believed to be important initiating factors in atherosclerosis. Oxidized LDL is recognized by the immune system, and…”
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Mobilization of regulatory T cells in response to carotid injury does not influence subsequent neointima formation by Saxena, Amit, Björkbacka, Harry, Ström, Åsa, Rattik, Sara, Berg, Katarina E, Gomez, Maria F, Fredrikson, Gunilla Nordin, Nilsson, Jan, Hultgårdh-Nilsson, Anna

“…T cells have been attributed an important role in modulating repair responses following vascular injury. The aim of this study was to investigate the role of…”
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Conjugated linoleic acid increased C-reactive protein in human subjects by Smedman, Annika, Basu, Samar, Jovinge, Stefan, Fredrikson, Gunilla Nordin, Vessby, Bengt

“…We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2α, a marker for cyclooxygenase-mediated lipid peroxidation…”
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Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease by FREDRIKSON, Gunilla Nordin, HEDBLAD, Bo, BERGLUND, Göran, AIM, Ragnar, NILSSON, Jan-Ake, SCHIOPU, Alexandru, SHAH, Prediman K, NILSSON, Jan

“…Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a…”
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Low Levels of Circulating CD4+FoxP3+ T Cells Are Associated With an Increased Risk for Development of Myocardial Infarction But Not for Stroke by Wigren, Maria, Björkbacka, Harry, Andersson, Linda, Ljungcrantz, Irena, Fredrikson, Gunilla Nordin, Persson, Margaretha, Bryngelsson, Carl, Hedblad, Bo, Nilsson, Jan

“…OBJECTIVE—Regulatory T cells (Tregs) protect against atherosclerosis in experimental models, but their association with cardiovascular disease in humans…”
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Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels by FREDRIKSON, Gunilla Nordin, HEDBLAD, Bo, NILSSON, Jan-Ake, ALM, Ragnar, BERGLUND, Göran, NILSSON, Jan

“…Increased C-reactive protein (CRP) levels have been associated with several of the components of the metabolic syndrome, but the direct influence of diet and…”
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Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events by Björkbacka, Harry, Alm, Ragnar, Persson, Margaretha, Hedblad, Bo, Nilsson, Jan, Fredrikson, Gunilla Nordin

“…OBJECTIVE—Previous smaller studies have indicated inverse associations between autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular…”
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Oxidized LDL antibodies in treatment and risk assessment of atherosclerosis and associated cardiovascular disease by Nilsson, Jan, Nordin Fredrikson, Gunilla, Schiopu, Alexandru, Shah, Prediman K, Jansson, Bo, Carlsson, Roland

“…Immune responses against oxidized forms of LDL play a critical role in activation and regulation of the inflammatory process that characterizes all stages of…”
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Adsorption of low-density lipoprotein, its oxidation, and subsequent binding of specific recombinant antibodies: An in situ ellipsometric study by Stollenwerk, Maria M, Svensson, Olof, Schiopu, Alexandru, Jansson, Bo, Arnebrant, Thomas, Fredrikson, Gunilla Nordin

“…Low-density lipoprotein (LDL) particles accumulate in the arterial wall and become oxidized during atherogenesis, leading to the formation of atherosclerotic…”
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High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage by Söderholm, Martin, Nordin Fredrikson, Gunilla, Nilsson, Jan, Engström, Gunnar

“…BACKGROUND AND PURPOSE—Increased degradation of the extracellular matrix in the arterial wall by matrix metalloproteinases (MMPs) may be an important mechanism…”
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Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis – A review of the experimental evidence by Björkbacka, Harry, Fredrikson, Gunilla Nordin, Nilsson, Jan

“…Abstract The role of inflammation in atherosclerosis and plaque vulnerability is well recognized. However, it is only during recent years it has become evident…”
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Lack of Ability to Present Antigens on Major Histocompatibility Complex Class II Molecules Aggravates Atherosclerosis in ApoE−/− Mice by Wigren, Maria, Rattik, Sara, Yao Mattisson, Ingrid, Tomas, Lukas, Grönberg, Caitriona, Söderberg, Ingrid, Alm, Ragnar, Sundius, Lena, Ljungcrantz, Irena, Björkbacka, Harry, Fredrikson, Gunilla Nordin, Nilsson, Jan

“…BACKGROUND:Hypercholesterolemic mice lacking factors required for activation of CD4 T cells are characterized by reduced development of atherosclerosis…”
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Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice by Herbin, Olivier, Ait-Oufella, Hafid, Yu, Wang, Fredrikson, Gunilla Nordin, Aubier, Benjamin, Perez, Nicolas, Barateau, Véronique, Nilsson, Jan, Tedgui, Alain, Mallat, Ziad

“…OBJECTIVE—The immunoinflammatory response plays a critical role in the development and progression of atherosclerosis. Recent studies suggested an important…”
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