Search Results - "FRAZER, John"

Evaluating the effects of switching from cigarette smoking to using a heated tobacco product on health effect indicators in healthy subjects: study protocol for a randomized controlled trial by Newland, Nik, Lowe, Frazer John, Camacho, Oscar Martin, McEwan, Mike, Gale, Nathan, Ebajemito, James, Hardie, George, Murphy, James, Proctor, Christopher

“…Tobacco heating products (THPs) are a potentially safer alternative to combustible cigarette smoking. Through continued use, THPs may reduce smoking-related…”
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A Case of Acute Intermittent Porphyria Leading to Severe Disability in a Young 21-Year-Old Female by Ramzan, Adil, Cao, Jenny Jia Ling, Frazer, John S, Stein, Penelope, Ahmad, Shakeel

“…Acute intermittent porphyria (AIP) is a rare metabolic disorder that is challenging to diagnose and treat. Symptoms are nonspecific and severe acute attacks…”
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Analysis of primary care prescription trends in England during the COVID-19 pandemic compared against a predictive model by Frazer, John Scott, Frazer, Glenn Ross

“…ObjectivesThe COVID-19 pandemic has had an unprecedented impact across primary care. Primary care services have seen an upheaval, and more and more patients…”
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GP prescribing in Northern Ireland by deprivation index: retrospective analysis by Frazer, John Scott, Frazer, Glenn Ross

“…ObjectiveIn the present study, we sought to explore the relationship between socioeconomic status and prescribing magnitude and cost in primary care throughout…”
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Shape optimisation using evolutionary techniques in product design by Sun, Jian, Frazer, John H., Mingxi, Tang

“…Shape or surface optimisation in product design is a very essential and time-consuming process, especially at the conceptual design stage. In this paper, we…”
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Zebrafish MYC-induced leukemia models: unique in vivo systems to study B and T cell acute lymphoblastic leukemia by Borga, Chiara, Frazer, John Kimble

“…[...]zebrafish T-ALL studies have pioneered these strategies. Despite their near-identical composition, gene expression analysis revealed mMyc and hMYC B-ALL…”
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Parametric Computation: History and Future by Frazer, John

“…John Frazer is a pioneer and leader in the field of generative design and evolutionary computation. In the 1970s he developed the world's first…”
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Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M., Yoon, Woo H., Whelan, Kevin, Sanabria, Erin K., Grottick, Andrew J., Al-Shamma, Hussien, Semple, Graeme

“…A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds…”
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APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology by Adams, John W, Ramirez, Juan, Shi, Yunqing, Thomsen, William, Frazer, John, Morgan, Michael, Edwards, Jeffrey E, Chen, Weichao, Teegarden, Bradley R, Xiong, Yifeng, Al-Shamma, Hussien, Behan, Dominic P, Connolly, Daniel T

“…We have evaluated the receptor pharmacology, antiplatelet activity, and vascular pharmacology of APD791…”
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Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien

“…Recent developments in sleep research suggest that antagonism of the serotonin 5-HT(2A) receptor may improve sleep maintenance insomnia. We herein report the…”
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Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2A Receptor Antagonists for the Treatment of Insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien

“…Recent developments in sleep research suggest that antagonism of the serotonin 5-HT2A receptor may improve sleep maintenance insomnia. We herein report the…”
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A new family of H3 receptor antagonists based on the natural product Conessine by SANTORA, Vincent J, COVEL, Jonathan A, WEBB, Robert R, SAGE, Carleton, REN, Albert, PEREIRA, Guilherme, KNUDSEN, Jens, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, HAYASHI, Rena, WHELAN, Kevin, GROTTICK, Andrew J, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SENGUPTA, Dipanjan, DUFFIELD, Jonathan J, SEMPLE, Graeme

“…A new family of Histamine H(3) receptor antagonists (5a-t) has been prepared based on the structure of the natural product Conessine, a known H(3) antagonist…”
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916) by Semple, Graeme, Santora, Vincent J., Smith, Jeffrey M., Covel, Jonathan A., Hayashi, Rena, Gallardo, Charlemagne, Ibarra, Jason B., Schultz, Jeffrey A., Park, Douglas M., Estrada, Scott A., Hofilena, Brian J., Smith, Brian M., Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey E., Hart, Ryan, Hauser, Erin K., Lorea, Jodie, Grottick, Andrew J.

“…The design of a new clinical candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described…”
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Involvement of the open-source community in combating the worldwide COVID-19 pandemic: a review by Frazer, John Scott, Shard, Amelia, Herdman, James

“…The ongoing COVID-19 pandemic is unprecedented in the modern age both due to its scale and its disruption to daily life throughout the world. Widespread social…”
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Who are sexual offenders? A survey of pre-trial psychiatric reports by Balasundaram, Bharathi, Frazer, John B., Wood, Peter J. W.

“…Sexual offending is a serious and growing problem in our society. The aim of the study was to investigate the main characteristics of people charged with…”
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Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor by Gaidarov, Ibragim, Adams, John, Frazer, John, Anthony, Todd, Chen, Xiaohua, Gatlin, Joel, Semple, Graeme, Unett, David J.

“…Angiotensin (1–7) has been reported to be a ligand for the GPCR MAS1. Small molecule MAS1 modulators have also been recently characterized. Aside from…”
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Trends in medication use at the onset of and during the COVID‐19 pandemic in the Republic of Ireland: An interrupted time series study by Mattsson, Molly, Hong, Jung Ah, Frazer, John Scott, Frazer, Glenn Ross, Moriarty, Frank

“…The COVID‐19 pandemic had a substantial impact on healthcare delivery, particularly in general practice. This study aimed to evaluate how dispensing of…”
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The cybernetics of architecture: a tribute to the contribution of Gordon Pask by Hamilton Frazer, John

“…Discusses the relation between cybernetics and architecture and pays tribute to Gordon Pask's role and influence. Indicates Pask's contribution to an…”
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Severe GI Toxicities Remain a Significant Source of Clinical Meaningful Morbidity Especially in Older Patients Receiving Autologous Transplant for Lymphoma by Shouse, Geoffrey, Frank, Annabel Kate, Aggarwal, Sanjay K., Kavalerchik, Edward, Frazer, John K, Finnegan, Paul, Fakhri, Bita

“…Introduction: High-dose chemotherapy and autologous hematopoietic cell transplant (HDT-AHCT) is considered a standard-of-care (SOC) consolidation therapy for…”
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Altered Transcription and Replication Driving MYC-Induced B and T Cell Leukemias by Sinha, Arpan A., Foster, Clay, Sansam, Courtney, Andrade, Pilar I., Foster, Katie, Malone-Perez, Megan, Sansam, Christopher, Frazer, John Kimble

“…MYC is over-expressed by many cancers, yet its oncogenic mechanisms are incompletely understood. MYC is central to acute lymphoblastic leukemia (ALL) - the…”
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