Search Results - "FRAVOLINI, Arnaldo"

Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones by Tabarrini, Oriana, Massari, Serena, Daelemans, Dirk, Stevens, Miguel, Manfroni, Giuseppe, Sabatini, Stefano, Balzarini, Jan, Cecchetti, Violetta, Pannecouque, Christophe, Fravolini, Arnaldo

“…On the basis of our recent findings that 6-aminoquinolones inhibit the HIV Tat-mediated transactivation, we have designed a broad series of derivatives…”
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New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action by PAROLIN, Cristina, GATTO, Barbara, DEL VECCHIO, Claudia, PECERE, Teresa, TRAMONTANO, Enzo, CECCHETTI, Violetta, FRAVOLINI, Arnaldo, MASIERO, Sara, PALUMBO, Manlio, PALU, Giorgio

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Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives by STEVENS, Miguel, POLLICITA, Michela, SCHOLS, Dominique, BALZARINI, Jan, PANNECOUQUE, Christophe, VERBEKEN, Erik, TABARRINI, Oriana, CECCHETTI, Violetta, AQUARO, Stefano, PERNO, Carlo Federico, FRAVOLINI, Arnaldo, DE CLERCQ, Erik

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2‐Phenylquinolones as Inhibitors of the HIV‐1 Tat–TAR Interaction by Gatto, Barbara, Tabarrini, Oriana, Massari, Serena, Giaretta, Giulia, Sabatini, Stefano, Del Vecchio, Claudia, Parolin, Cristina, Fravolini, Arnaldo, Palumbo, Manlio, Cecchetti, Violetta

“…Novel 2‐phenylquinolones aimed at the Tat–TAR complex were synthesized and tested. Derivatives characterized by precise modifications of the quinolone nucleus…”
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Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-Activation-Responsive Region Interaction by an Antiviral Quinolone Derivative by RICHTER, Sara, PAROLIN, Cristina, GATTO, Barbara, DEL VECCHIO, Claudia, BROCCA-COFANO, Egidio, FRAVOLINI, Arnaldo, PALU, Giorgio, PALUMBO, Manlio

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From Phenothiazine to 3-Phenyl-1,4-benzothiazine Derivatives as Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump by Sabatini, Stefano, Kaatz, Glenn W, Rossolini, Gian Maria, Brandini, David, Fravolini, Arnaldo

“…Overexpression of efflux pumps is an important mechanism by which bacteria evade effects of substrate antimicrobial agents and inhibition of such pumps is a…”
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Discovery of Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus by Brincat, Jean Pierre, Carosati, Emanuele, Sabatini, Stefano, Manfroni, Giuseppe, Fravolini, Arnaldo, Raygada, Jose L, Patel, Diixa, Kaatz, Glenn W, Cruciani, Gabriele

“…Four novel inhibitors of the NorA efflux pump of Staphylococcus aureus, discovered through a virtual screening process, are reported. The four compounds belong…”
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Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor by Manfroni, Giuseppe, Paeshuyse, Jan, Massari, Serena, Zanoli, Samantha, Gatto, Barbara, Maga, Giovanni, Tabarrini, Oriana, Cecchetti, Violetta, Fravolini, Arnaldo, Neyts, Johan

“…We report the synthesis and structure−activity relationship (SAR) of a large series of acridones and acridone-fragment derivatives designed on the basis of the…”
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From 6-Aminoquinolone Antibacterials to 6-Amino-7-thiopyranopyridinylquinolone Ethyl Esters as Inhibitors of Staphylococcus aureus Multidrug Efflux Pumps by Pieroni, Marco, Dimovska, Mirjana, Brincat, Jean Pierre, Sabatini, Stefano, Carosati, Emanuele, Massari, Serena, Kaatz, Glenn W, Fravolini, Arnaldo

“…The thiopyranopyridine moiety was synthesized as a new heterocyclic base to be inserted at the C-7 position of selected quinolone nuclei followed by a…”
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Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents by Tabarrini, Oriana, Manfroni, Giuseppe, Fravolini, Arnaldo, Cecchetti, Violetta, Sabatini, Stefano, De Clercq, Erik, Rozenski, Jef, Canard, Bruno, Dutartre, Hélène, Paeshuyse, Jan, Neyts, Johan

“…In this study we report the design, synthesis, and activity against bovine viral diarrhea virus (BVDV) of a novel series of acridone derivatives. BVDV is…”
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A Pharmacophore Hypothesis for P-Glycoprotein Substrate Recognition Using GRIND-Based 3D-QSAR by Cianchetta, Giovanni, Singleton, Robert W, Zhang, Meng, Wildgoose, Marianne, Giesing, Dennis, Fravolini, Arnaldo, Cruciani, Gabriele, Vaz, Roy J

“…Trying to understand the complex interactions that substrates and inhibitors have with the efflux transporter P-glycoprotein has been the subject of various…”
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Predictive models for hERG potassium channel blockers by Cianchetta, Giovanni, Li, Yi, Kang, Jiesheng, Rampe, David, Fravolini, Arnaldo, Cruciani, Gabriele, Vaz, Roy J.

“…Computational QSAR models constructed from pharmacophore-based GRIND descriptors were found to be predictive for hERG channel blockers. We report here a…”
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Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition by Manfroni, Giuseppe, Gatto, Barbara, Tabarrini, Oriana, Sabatini, Stefano, Cecchetti, Violetta, Giaretta, Giulia, Parolin, Cristina, Del Vecchio, Claudia, Calistri, Arianna, Palumbo, Manlio, Fravolini, Arnaldo

“…Fluorescence quenching analysis demonstrates that 2-phenylquinolone derivatives efficiently inhibit Tat/TAR recognition. Tat (transactivator of transcription)…”
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Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation by Stevens, Miguel, Balzarini, Jan, Tabarrini, Oriana, Andrei, Graciela, Snoeck, Robert, Cecchetti, Violetta, Fravolini, Arnaldo, De Clercq, Erik, Pannecouque, Christophe

“…Objectives: Quinolone derivatives have been shown to inhibit human immunodeficiency virus (HIV) replication at the transcriptional level. Recently, a series of…”
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Correction to From 6-Aminoquinolone Antibacterials to 6-Amino-7-thiopyranopyridinylquinolone Ethyl Esters as Inhibitors of Staphylococcus aureus Multidrug Efflux Pumps by Pieroni, Marco, Dimovska, Mirjana, Brincat, Jean Pierre, Sabatini, Stefano, Carosati, Emanuele, Massari, Serena, Kaatz, Glenn W, Fravolini, Arnaldo

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Highly Potent 1,4-Benzothiazine Derivatives as KATP-Channel Openers by Cecchetti, Violetta, Calderone, Vincenzo, Tabarrini, Oriana, Sabatini, Stefano, Filipponi, Enrica, Testai, Lara, Spogli, Roberto, Martinotti, Enrica, Fravolini, Arnaldo

“…A series of 1,4-benzothiazines, suitably functionalized at the N-4 and C-6 positions, arising from the replacement of a benzopyran-based structure of…”
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Highly Potent 1,4-Benzothiazine Derivatives as K ATP -Channel Openers by Cecchetti, Violetta, Calderone, Vincenzo, Tabarrini, Oriana, Sabatini, Stefano, Filipponi, Enrica, Testai, Lara, Spogli, Roberto, Martinotti, Enrica, Fravolini, Arnaldo

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Structure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity by Tabarrini, Oriana, Stevens, Miguel, Cecchetti, Violetta, Sabatini, Stefano, Dell'Uomo, Micaela, Manfroni, Giuseppe, Palumbo, Manlio, Pannecouque, Christophe, De Clercq, Erik, Fravolini, Arnaldo

“…We have recently discovered that 6-aminoquinolone derivatives could be valid leads for the development of new anti-HIV agents because of their new and…”
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6-Aminoquinolones as New Potential Anti-HIV Agents by Cecchetti, Violetta, Parolin, Cristina, Moro, Stefano, Pecere, Teresa, Filipponi, Enrica, Calistri, Arianna, Tabarrini, Oriana, Gatto, Barbara, Palumbo, Manlio, Fravolini, Arnaldo

“…A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a…”
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Antiviral 6-amino-quinolones: Molecular basis for potency and selectivity by Richter, Sara N., Gatto, Barbara, Tabarrini, Oriana, Fravolini, Arnaldo, Palumbo, Manlio

“…Structural modifications introduced in 6-amino-quinolones to increase antiviral activity can strongly affect cytotoxicity to host cells. By competition to…”
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