Search Results - "FRASER, D. C"

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration by Dorrington, Michael G, Fraser, Iain D C

“…The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-related pathways thanks to almost four decades of intense research. NF-κB…”
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Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection by Grainger, John R, Wohlfert, Elizabeth A, Fuss, Ivan J, Bouladoux, Nicolas, Askenase, Michael H, Legrand, Fanny, Koo, Lily Y, Brenchley, Jason M, Fraser, Iain D C, Belkaid, Yasmine

“…Monocytes play an important part in the clearance of pathogens during infection. Yasmine Belkaid and her colleagues now report that inflammatory monocytes can…”
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Identification of age-specific gene regulators of La Crosse virus neuroinvasion and pathogenesis by Basu, Rahul, Ganesan, Sundar, Winkler, Clayton W., Anzick, Sarah L., Martens, Craig, Peterson, Karin E., Fraser, Iain D. C.

“…One of the key events in viral encephalitis is the ability of virus to enter the central nervous system (CNS). Several encephalitic viruses, including La…”
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Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol by Dorrington, Michael G, Bradfield, Clinton J, Lack, Justin B, Lin, Bin, Liang, Jonathan J, Starr, Tregei, Ernst, Orna, Gross, Julia L, Sun, Jing, Miller, Alexandra H, Steele-Mortimer, Olivia, Fraser, Iain D C

“…The mammalian immune system is constantly challenged by signals from both pathogenic and non-pathogenic microbes. Many of these non-pathogenic microbes have…”
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A Single Lentiviral Vector Platform for MicroRNA-Based Conditional RNA Interference and Coordinated Transgene Expression by Shin, Kum-Joo, Wall, Estelle A., Zavzavadjian, Joelle R., Santat, Leah A., Liu, Jamie, Hwang, Jong-lk, Rebres, Robert, Roach, Tamara, Seaman, William, Simon, Melvin I., Fraser, Iain D. C.

“…RNAi is proving to be a powerful experimental tool for the functional annotation of mammalian genomes. The full potential of this technology will be realized…”
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Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol by Dorrington, Michael G, Bradfield, Clinton J, Lack, Justin B, Lin, Bin, John, Sinu P, Liang, Jonathan J, Starr, Tregei, Ernst, Orna, Gross, Julia L, Sun, Jing, Miller, Alexandra H, Steele-Mortimer, Olivia, Fraser, Iain D. C

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The ontogeny of cerebrovascular pressure autoregulation in premature infants by Rhee, C J, Fraser III, C D, Kibler, K, Easley, R B, Andropoulos, D B, Czosnyka, M, Varsos, G V, Smielewski, P, Rusin, C G, Brady, K M, Kaiser, J R

“…Objective: To quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle. Study design: The…”
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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies by Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.

“…Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have…”
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Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 by Sakai, Jiro, Cammarota, Eugenia, Wright, John A., Cicuta, Pietro, Gottschalk, Rachel A., Li, Ning, Fraser, Iain D. C., Bryant, Clare E.

“…TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of the transcription factor NF-κB into the nucleus. In cell population…”
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Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways by Manes, Nathan P., Calzola, Jessica M., Kaplan, Pauline R., Fraser, Iain D. C., Germain, Ronald N., Meier-Schellersheim, Martin, Nita-Lazar, Aleksandra

“…The Toll-like receptor (TLR) and chemotaxis pathways are key components of the innate immune system. Subtle variation in the concentration, timing, and…”
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Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics by Ernst, Orna, Khan, Mohd M, Oyler, Benjamin L, Yoon, Sung Hwan, Sun, Jing, Lin, Fang-Yu, Manes, Nathan P, MacKerell, Jr, Alexander D, Fraser, Iain D C, Ernst, Robert K, Goodlett, David R, Nita-Lazar, Aleksandra

“…The innate immune system is the body's first line of defense against pathogens and its protection against infectious diseases. On the surface of host myeloid…”
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Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex by Westphal, Ryan S., Tavalin, Steven J., Lin, Jerry W., Alto, Neal M., Lain D. C. Fraser, Langeberg, Lorene K., Sheng, Morgan, Scott, John D.

“…Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of…”
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Lipid regulation of NLRP3 inflammasome activity through organelle stress by Liang, Jonathan J., Fraser, Iain D.C., Bryant, Clare E.

“…Inflammation driven by the NLRP3 inflammasome in macrophages is an important contributor to chronic metabolic diseases that affect growing numbers of…”
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Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use by Sun, Jing, Li, Ning, Oh, Kyu-Seon, Dutta, Bhaskar, Vayttaden, Sharat J, Lin, Bin, Ebert, Thomas S, De Nardo, Dominic, Davis, Joie, Bagirzadeh, Rustam, Lounsbury, Nicolas W, Pasare, Chandrashekhar, Latz, Eicke, Hornung, Veit, Fraser, Iain D C

“…Toll-like receptors (TLRs) are a major class of pattern recognition receptors, which mediate the responses of innate immune cells to microbial stimuli. To…”
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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis by Bradfield, Clinton J., Liang, Jonathan J., Ernst, Orna, John, Sinu P., Sun, Jing, Ganesan, Sundar, de Jesus, Adriana A., Bryant, Clare E., Goldbach-Mansky, Raphaela, Fraser, Iain D. C.

“…Kinase signaling in the tiered activation of inflammasomes and associated pyroptosis is a prime therapeutic target for inflammatory diseases. While MAPKs…”
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Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death by Basu, Rahul, Nair, Vinod, Winkler, Clayton W, Woods, Tyson A, Fraser, Iain D C, Peterson, Karin E

“…A key factor in the development of viral encephalitis is a virus crossing the blood-brain barrier (BBB). We have previously shown that age-related…”
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The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages by Zor, Tsaffrir, Levy-Rimler, Galit, Ben-Arosh, Hadar, Ben-Dror, Iris, Athamna, Muhammad, Glucksam-Galnoy, Yifat, Ernst, Orna, Fraser, Iain D. C.

“…Interleukin-10 (IL-10) is a key anti-inflammatory cytokine, secreted by macrophages and other immune cells to attenuate inflammation. Autocrine type I…”
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Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action by Oh, Kyu-Seon, Patel, Heta, Gottschalk, Rachel A., Lee, Wai Shing, Baek, Songjoon, Fraser, Iain D.C., Hager, Gordon L., Sung, Myong-Hee

“…Despite the widespread use of glucocorticoids (GCs), their anti-inflammatory effects are not understood mechanistically. Numerous investigations have examined…”
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Dynamic ADP-Ribosylome, Phosphoproteome, and Interactome in LPS-Activated Macrophages by Daniels, Casey M, Kaplan, Pauline R, Bishof, Isaac, Bradfield, Clinton, Tucholski, Trisha, Nuccio, Arthur G, Manes, Nathan P, Katz, Samuel, Fraser, Iain D. C, Nita-Lazar, Aleksandra

“…We have used mass spectrometry (MS) to characterize protein signaling in lipopolysaccharide (LPS)-stimulated macrophages from human blood, human THP1 cells,…”
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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons by Welsbie, Derek S., Mitchell, Katherine L., Jaskula-Ranga, Vinod, Sluch, Valentin M., Yang, Zhiyong, Kim, Jessica, Buehler, Eugen, Patel, Amit, Martin, Scott E., Zhang, Ping-Wu, Ge, Yan, Duan, Yukan, Fuller, John, Kim, Byung-Jin, Hamed, Eman, Chamling, Xitiz, Lei, Lei, Fraser, Iain D.C., Ronai, Ze’ev A., Berlinicke, Cynthia A., Zack, Donald J.

“…Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To…”
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