Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine

The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 10; no. 6; pp. 597 - 600
Main Authors:	YOUNG, R. J, BEAMS, R. M, FRENCH, C, HODGSON, S. T, HODSON, H. F, KLEANTHOUS, S, RIDER, P, SANDERS, D, SAWYER, D. A, SCOTT, K. J, SHEARER, B. G, STOCKER, R, CARTER, K, SMITH, S, TACKLEY, M. C, KNOWLES, R. G, CLARK, H. A. R, COE, D. M, CHAMBERS, C. L, DAVIES, P. I, DAWSON, J, DRYSDALE, M. J, FRANZMAN, K. W
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 20-03-2000
Subjects:	Acetamides - chemical synthesis Acetamides - pharmacology Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Humans Indicators and Reagents Isoenzymes - antagonists & inhibitors Lysine - analogs & derivatives Lysine - chemical synthesis Lysine - pharmacology Medical sciences Miscellaneous Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Ornithine - analogs & derivatives Ornithine - pharmacology Pharmacology. Drug treatments Sulfides - pharmacology Sulfones - pharmacology Human Ether Sulfone Enzyme Isozyme Enzyme inhibitor Selectivity In vitro Nitric-oxide synthase Organic sulfide Sulfur containing aminoacid α-Aminoacid Amidine Structure activity relation Sulfoxide Oxidoreductases Chemical synthesis
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Summary:	The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00055-X