Search Results - "FRANTZ, Gretchen D"

ubiquitin ligase COP1 is a critical negative regulator of p53 by Dornan, D, Wertz, I, Shimizu, H, Arnott, D, Frantz, G.D, Dowd, P, O'Rourke, K, Koeppen, H, Dixit, V.M

“…COP1 (constitutively photomorphogenic 1) is a RING-finger-containing protein that functions to repress plant photomorphogenesis, the light-mediated programme…”
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Impact of Vascular Endothelial Growth Factor-A Expression, Thrombospondin-2 Expression, and Microvessel Density on the Treatment Effect of Bevacizumab in Metastatic Colorectal Cancer by JUBB, Adrian M, HURWITZ, Herbert I, HILLAN, Kenneth, KOEPPEN, Hartmut, WEI BAI, HOLMGREN, Eric B, TOBIN, Patti, GUERRERO, A. Steven, KABBINAVAR, Fairooz, HOLDEN, Scott N, NOVOTNY, William F, FRANTZ, Gretchen D

“…Bevacizumab is a monoclonal antibody to vascular endothelial growth factor-A (VEGF). In the pivotal trial in metastatic colorectal cancer (mCRC), addition of…”
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Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival by Holst, Charles R, Bou-Reslan, Hani, Gore, Bryan B, Wong, Karen, Grant, Deanna, Chalasani, Sreedevi, Carano, Richard A, Frantz, Gretchen D, Tessier-Lavigne, Marc, Bolon, Brad, French, Dorothy M, Ashkenazi, Avi

“…Heparan sulfate proteoglycans (HSPGs) use highly sulfated polysaccharide side-chains to interact with several key growth factors and morphogens, thereby…”
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COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas by DORNAN, David, BHEDDAH, Sheila, NEWTON, Kim, INCE, William, FRANTZ, Gretchen D, DOWD, Patrick, KOEPPEN, Hartmut, DIXIT, Vishva M, FRENCH, Dorothy M

“…The tumor suppressor protein p53 plays a central role in protecting normal cells from undergoing transformation. Thus, it is fitting that cancer cells…”
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Tumor-Driven Paracrine Platelet-Derived Growth Factor Receptor α Signaling Is a Key Determinant of Stromal Cell Recruitment in a Model of Human Lung Carcinoma by TEJADA, Max L, LANLAN YU, FERRARA, Napoleone, JIANYING DONG, JUNG, Kenneth, MENG, Gloria, PEALE, Franklin V, FRANTZ, Gretchen D, HALL, Linda, XIAOHUAN LIANG, GERBER, Hans-Peter

“…Activated fibroblasts are thought to play important roles in the progression of many solid tumors, but little is known about the mechanisms responsible for the…”
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EphB2 is a Prognostic Factor in Colorectal Cancer by JUBB, Adrian M, ZHONG, Fiona, BHEDDAH, Sheila, GRABSCH, Heike I, FRANTZ, Gretchen D, MUELLER, Wolfram, KAVI, Vidya, QUIRKE, Phil, POLAKIS, Paul, KOEPPEN, Hartmut

“…A receptor tyrosine kinase for ephrin ligands, EphB2 is expressed in colorectal cancer and has been proposed as a target for immunoconjugate therapy. The aim…”
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Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus by Merchant, Mark, Evangelista, Marie, Luoh, Shiuh-Ming, Frantz, Gretchen D., Chalasani, Sreedevi, Carano, Richard A. D., van Hoy, Marjie, Ramirez, Julio, Ogasawara, Annie K., McFarland, Leanne M., Filvaroff, Ellen H., French, Dorothy M., de Sauvage, Frederic J.

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Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods by Pisabarro, M. Teresa, Leung, Beatrice, Kwong, Mandy, Corpuz, Racquel, Frantz, Gretchen D, Chiang, Nancy, Vandlen, Richard, Diehl, Lauri J, Skelton, Nicholas, Kim, Hok Seon, Eaton, Dan, Schmidt, Kerstin N

“…Chemokines play an important role in the immune system by regulating cell trafficking in homeostasis and inflammation. In this study, we report the…”
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Restriction of Late Cerebral Cortical Progenitors to an Upper-Layer Fate by Frantz, Gretchen D, McConnell, Susan K

“…Early in development, neural progenitors in cerebral cortex normally produce neurons of several layers during successive cell divisions. The laminar fate of…”
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Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency by Newton, Kim, French, Dorothy M., Yan, Minhong, Frantz, Gretchen D., Dixit, Vishva M.

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A Mouse Model of Hepatocellular Carcinoma : Ectopic Expression of Fibroblast Growth Factor 19 in Skeletal Muscle of Transgenic Mice by Nicholes, Katrina, Guillet, Susan, Tomlinson, Elizabeth, Hillan, Kenneth, Wright, Barbara, Frantz, Gretchen D, Pham, Thinh A, Dillard-Telm, Lisa, Tsai, Siao Ping, Stephan, Jean-Philippe, Stinson, Jeremy, Stewart, Timothy, French, Dorothy M

“…Most mouse models of hepatocellular carcinoma have expressed growth factors and oncogenes under the control of a liver-specific promoter. In contrast, we…”
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FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family by Holcomb, Ilona N., Kabakoff, Rhona C., Chan, Betty, Baker, Thad W., Gurney, Austin, Henzel, William, Nelson, Chris, Lowman, Henry B., Wright, Barbara D., Skelton, Nicholas J., Frantz, Gretchen D., Tumas, Daniel B., Peale, Jr, Franklin V., Shelton, David L., Hébert, Caroline C.

“…Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine‐rich secreted protein,…”
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WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair by French, Dorothy M., Kaul, Raji J., D'souza, Aloma L., Crowley, Craig W., Bao, Min, Frantz, Gretchen D., Filvaroff, Ellen H., Desnoyers, Luc

“…Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Experimental evidence…”
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Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF) by Strickland, Laura A, Jubb, Adrian M, Hongo, Jo-Anne, Zhong, Fiona, Burwick, Jennifer, Fu, Ling, Frantz, Gretchen D, Koeppen, Hartmut

“…Vascular endothelial growth factor‐A (VEGF) is an important regulator of vascular permeability. In preclinical studies, VEGF induces endothelial fenestrations…”
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Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid by SZETO, Wayne, WEN JIANG, GRIMALDI, J. Christopher, CORPUZ, Racquel T, SINGH, Jennifer S, FRANTZ, Gretchen D, DEVAUX, Brigitte, CROWLEY, Craig W, SCHWALL, Ralph H, EBERHARD, David A, RASTELLI, Luca, POLAKIS, Paul, TICE, David A, PENNICA, Diane, RUBINFELD, Bonnee, HOLLINGSHEAD, Philip G, FONG, Sharon E, DUGGER, Debra L, PHAM, Thinh, YANSURA, Daniel G, WONG, Terence A

“…Genetic defects in the Wnt-1 signaling pathway contribute to human tumor progression and are especially prevalent in colorectal cancer. We screened mouse C57MG…”
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Quantitative in situ hybridization of tissue microarrays by Jubb, Adrian M, Pham, Thinh Q, Frantz, Gretchen D, Peale, Jr, Franklin V, Hillan, Kenneth J

“…Tissue microarrays enable the rapid histological localization of gene expression in hundreds of archival samples by in situ hybridization. However, the scoring…”
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GEPIS—quantitative gene expression profiling in normal and cancer tissues by Zhang, Yan, Eberhard, David A., Frantz, Gretchen D., Dowd, Patrick, Wu, Thomas D., Zhou, Yan, Watanabe, Colin, Luoh, Shiuh-Ming, Polakis, Paul, Hillan, Kenneth J., Wood, William I., Zhang, Zemin

“…Motivation: Expression profiling in diverse tissues is fundamental to understanding gene function as well as therapeutic target identification. The vast…”
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Detection of novel gene expression in paraffin-embedded tissues by isotopic in situ hybridization in tissue microarrays by Frantz, Gretchen D., Pham, Thinh Q., Peale Jr, Franklin V., Hillan, Kenneth J.

“…Correlating altered gene expression patterns with particular disease states is a critical step in understanding disease processes and developing treatment…”
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Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear by Lewis, Annette K., Frantz, Gretchen D., Carpenter, David A., de Sauvage, Frederic J., Gao, Wei-Qiang

“…The cochlea and vestibular structures of the inner ear labyrinth develop from the otic capsule via step-wise regional and cell fate specification. Each inner…”
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DNA methylation in genomic imprinting, development, and disease by Paulsen, Martina, Ferguson-Smith, Anne C.

“…Changes in DNA methylation profiles are common features of development and in a number of human diseases, such as cancer and imprinting disorders like…”
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