Search Results - "FRANKEL, Arthur E"

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients by Frankel, Arthur E., Coughlin, Laura A., Kim, Jiwoong, Froehlich, Thomas W., Xie, Yang, Frenkel, Eugene P., Koh, Andrew Y.

“…This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma…”
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Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients by Frankel, Arthur E., Woo, Jung H., Ahn, Chul, Pemmaraju, Naveen, Medeiros, Bruno C., Carraway, Hetty E., Frankfurt, Olga, Forman, Stephen J., Yang, Xuezhong A., Konopleva, Marina, Garnache-Ottou, Francine, Angelot-Delettre, Fanny, Brooks, Christopher, Szarek, Michael, Rowinsky, Eric

“…This is the first prospective study of treatment of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic malignancy…”
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Autoimmune Bell's Palsy Following Immunotherapy For Metastatic Melanoma: A Report of 2 Cases by Zieman, Daniel, Frankel, Arthur E

“…By targeting receptors that serve to downregulate the cellular immune system, monoclonal antibodies such as ipilimumab and nivolumab have transformed the…”
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Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy by Yum, Seoyun, Li, Minghao, Frankel, Arthur E, Chen, Zhijian J

“…Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that initiates innate immune responses. DNA-bound cGAS produces cyclic GMP-AMP (cGAMP), which…”
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Clinical Activity and Tolerability of SL-401 (Tagraxofusp): Recombinant Diphtheria Toxin and Interleukin-3 in Hematologic Malignancies by Alkharabsheh, Omar, Frankel, Arthur E

“…Overcoming the leukemia stem cell resistance to intensive chemotherapy has been an area of extensive research over the last two decades. Advances and greater…”
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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells by Khoury, Oula, Ghazale, Noura, Stone, Everett, El-Sibai, Mirvat, Frankel, Arthur E., Abi-Habib, Ralph J.

“…In this study, we attempt to target Arginine auxotrophy in glioblastoma multiforme (GBM) cells using a pegylated recombinant human Arginase I cobalt [HuArgI…”
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Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients by Frankel, Arthur E, Eskiocak, Ugur, Gill, Jennifer G, Yuan, Stacy, Ramesh, Vijayashree, Froehlich, Thomas W, Ahn, Chul, Morrison, Sean J

“…Abstract This is the first prospective study of a combination therapy involving a cardenolide and a MEK inhibitor for metastatic melanoma. Whereas BRAF mutant…”
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Developing EZH2-Targeted Therapy for Lung Cancer by Frankel, Arthur E, Liu, Xin, Minna, John D

“…Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown…”
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The Human Microbiota in Multiple Myeloma and Proteasome Inhibitors by Alkharabsheh, Omar, Sidiqi, M Hasib, Aljama, Mohammed A, Gertz, Morie A, Frankel, Arthur E

“…The gut microbiota plays a significant role in health and disease, including cancer development and treatment. The importance of the gut microbiota in the…”
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Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota by Frankel, Arthur E., Deshmukh, Sachin, Reddy, Amit, Lightcap, John, Hayes, Maureen, McClellan, Steven, Singh, Seema, Rabideau, Brooks, Glover, T. Grant, Roberts, Bruce, Koh, Andrew Y.

“…The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune…”
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Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma by Frankel, Arthur E, Woo, Jung H, Ahn, Chul, Foss, Francine M, Duvic, Madeleine, Neville, Paul H, Neville, David M

“…Resimmune is a second-generation recombinant immunotoxin composed of the catalytic and translocation domains of diphtheria toxin fused to two single chain…”
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Phase I study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies by Bachanova, Veronika, Frankel, Arthur E, Cao, Qing, Lewis, Dixie, Grzywacz, Bartosz, Verneris, Michael R, Ustun, Celalettin, Lazaryan, Aleksandr, McClune, Brian, Warlick, Erica D, Kantarjian, Hagop, Weisdorf, Daniel J, Miller, Jeffrey S, Vallera, Daniel A

“…The novel bispecific ligand-directed toxin (BLT) DT2219 consists of a recombinant fusion between the catalytic and translocation enhancing domain of diphtheria…”
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Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia by Agrawal, Vaidehi, Woo, Jung Hee, Borthakur, Gautham, Kantarjian, Hagop, Frankel, Arthur E

“…Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood…”
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Tumor endothelial marker 8 promotes cancer progression and metastasis by Høye, Anette M, Tolstrup, Sofie D, Horton, Edward R, Nicolau, Monica, Frost, Helen, Woo, Jung H, Mauldin, Jeremy P, Frankel, Arthur E, Cox, Thomas R, Erler, Janine T

“…Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of…”
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Regulation of HMGB1 release by autophagy by Thorburn, Jacqueline, Frankel, Arthur E., Thorburn, Andrew

“…The characteristics of tumor cell killing by an anti-cancer agent can determine the long-term effectiveness of the treatment.  For example, if dying tumor…”
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RLIP76 and Cancer by Awasthi, Sanjay, Singhal, Sharad S, Awasthi, Yogesh C, Martin, Bryan, Woo, Jung-Hee, Cunningham, C Casey, Frankel, Arthur E

“…RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy…”
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Response to pegylated interferon in a COVID‐19 positive male with metastatic jejunal neuroendocrine tumor treated with everolimus by Frankel, Arthur E., Yip, Wai C., Naik, Eknath, Hasselbalch, Hans C.

“…A 61‐year‐old male on everolimus had chronic SARS‐CoV‐2 infection. Addition of pegylated interferon cleared viral RNA and supports combination therapy with…”
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Response to pegylated interferon in a COVID‐19–positive elderly woman with primary myelofibrosis treated with ruxolitinib by Frankel, Arthur E., Reddy, Renuka, DeSuza, Kayla R., Deeb, Khaled, Carlin, Aaron F., Smith, Davey, Xie, Yushuang, Naik, Eknath, Silver, Richard T., Hasselbalch, Hans C.

“…An 83‐year‐old female had asymptomatic SARS‐CoV‐2 infection while taking ruxolitinib. She remained RT‐PCR positive for viral RNA for >120 days, and Pegylated…”
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A STING-activating nanovaccine for cancer immunotherapy by Luo, Min, Wang, Hua, Wang, Zhaohui, Cai, Haocheng, Lu, Zhigang, Li, Yang, Du, Mingjian, Huang, Gang, Wang, Chensu, Chen, Xiang, Porembka, Matthew R., Lea, Jayanthi, Frankel, Arthur E., Fu, Yang-Xin, Chen, Zhijian J., Gao, Jinming

“…STING-activating nanoparticle vaccines achieve robust activation of tumour-specific T cells for cancer immunotherapy. The generation of tumour-specific T cells…”
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Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma by Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Frankel, Arthur E., Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.

“…Nature Communications 7 Article number:12336 (2016); Published 22 August 2016; Updated 29 September 2016 Arthur E. Frankel, who helped to interpret the…”
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