Search Results - "FRANK, M. R"

Viral-bacterial interactions in the respiratory tract by Bellinghausen, Carla, Rohde, Gernot G U, Savelkoul, Paul H M, Wouters, Emiel F M, Stassen, Frank R M

“…In the respiratory tract, viruses and bacteria can interact on multiple levels. It is well known that respiratory viruses, particularly influenza viruses,…”
Get full text

How to Count Our Microbes? The Effect of Different Quantitative Microbiome Profiling Approaches by Galazzo, Gianluca, van Best, Niels, Benedikter, Birke J, Janssen, Kevin, Bervoets, Liene, Driessen, Christel, Oomen, Melissa, Lucchesi, Mayk, van Eijck, Pascalle H, Becker, Heike E F, Hornef, Mathias W, Savelkoul, Paul H, Stassen, Frank R M, Wolffs, Petra F, Penders, John

“…Next-generation sequencing (NGS) has instigated the research on the role of the microbiome in health and disease. The compositional nature of such microbiome…”
Get full text

Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection by Volgers, Charlotte, Benedikter, Birke J, Grauls, Gert E, Savelkoul, Paul H M, Stassen, Frank R M

“…During infection, inflammation is partially driven by the release of mediators which facilitate intercellular communication. Amongst these mediators are small…”
Get full text

Higher Prevalence of Bacteroides fragilis in Crohn's Disease Exacerbations and Strain-Dependent Increase of Epithelial Resistance by Becker, Heike E F, Jamin, Casper, Bervoets, Liene, Boleij, Annemarie, Xu, Pan, Pierik, Marie J, Stassen, Frank R M, Savelkoul, Paul H M, Penders, John, Jonkers, Daisy M A E

“…has previously been linked to Crohn's disease (CD) exacerbations, but results are inconsistent and underlying mechanisms unknown. This study investigates the…”
Get full text

Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles by Benedikter, Birke J., Bouwman, Freek G., Heinzmann, Alexandra C. A., Vajen, Tanja, Mariman, Edwin C., Wouters, Emiel F. M., Savelkoul, Paul H. M., Koenen, Rory R., Rohde, Gernot G. U., van Oerle, Rene, Spronk, Henri M., Stassen, Frank R. M.

“…Airway epithelial cells secrete extracellular vesicles (EVs) under basal conditions and when exposed to cigarette smoke extract (CSE). Getting insights into…”
Get full text

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis by Corsten, Maarten F, Papageorgiou, Anna, Verhesen, Wouter, Carai, Paolo, Lindow, Morten, Obad, Susanna, Summer, Georg, Coort, Susan L.M, Hazebroek, Mark, van Leeuwen, Rick, Gijbels, Marion J.J, Wijnands, Erwin, Biessen, Erik A.L, De Winther, Menno P.J, Stassen, Frank R.M, Carmeliet, Peter, Kauppinen, Sakari, Schroen, Blanche, Heymans, Stephane

“…RATIONALE:Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in…”
Get full text

Community-based participatory research and the challenges of qualitative analysis enacted by lay, nurse, and academic researchers by Foster, Jennifer W., Chiang, Fidela, Burgos, Rosa I., Cáceres, Ramona E., Tejada, Carmen M., Almonte, Asela T., Noboa, Frank R.M., Perez, Lidia J., Urbaez, Marilín F., Heath, Annemarie

“…There are multiple challenges in adhering to the principles of community‐based participatory research (CBPR), especially when there is a wide range of academic…”
Get full text

Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies by Benedikter, Birke J., Bouwman, Freek G., Vajen, Tanja, Heinzmann, Alexandra C. A., Grauls, Gert, Mariman, Edwin C., Wouters, Emiel F. M., Savelkoul, Paul H., Lopez-Iglesias, Carmen, Koenen, Rory R., Rohde, Gernot G. U., Stassen, Frank R. M.

“…Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis…”
Get full text

Gram-negative bacterial membrane vesicle release in response to the host-environment: different threats, same trick? by Volgers, Charlotte, Savelkoul, Paul H M, Stassen, Frank R M

“…Bacteria are confronted with a multitude of stressors when occupying niches within the host. These stressors originate from host defense mechanisms, other…”
Get more information

Redox-dependent thiol modifications: implications for the release of extracellular vesicles by Benedikter, Birke J., Weseler, Antje R., Wouters, Emiel F. M., Savelkoul, Paul H. M., Rohde, Gernot G. U., Stassen, Frank R. M.

“…Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as important regulators of homeostasis and pathophysiology. During…”
Get full text

Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease by Gosens, Reinoud, Hiemstra, Pieter S, Adcock, Ian M, Bracke, Ken R, Dickson, Robert P, Hansbro, Philip M, Krauss-Etschmann, Susanne, Smits, Hermelijn H, Stassen, Frank R M, Bartel, Sabine

“…Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades,…”
Get full text

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants by Benedikter, Birke J., Volgers, Charlotte, van Eijck, Pascalle H., Wouters, Emiel F.M., Savelkoul, Paul H.M., Reynaert, Niki L., Haenen, Guido R.M.M., Rohde, Gernot G.U., Weseler, Antje R., Stassen, Frank R.M.

“…Airway epithelial cells have been described to release extracellular vesicles (EVs) with pathological properties when exposed to cigarette smoke extract (CSE)…”
Get full text

Characterization of Feces-Derived Bacterial Membrane Vesicles and the Impact of Their Origin on the Inflammatory Response by Kameli, Nader, Borman, Reitske, López-Iglesias, Carmen, Savelkoul, Paul, Stassen, Frank R.M.

“…The human gastrointestinal tract harbors a diverse and complex microbiome, which interacts in a variety of ways with the host. There is compelling evidence…”
Get full text

Chlamydia pneumoniae infection of brain cells: An in vitro study by Boelen, Ellen, Steinbusch, Harry W.M, van der Ven, André J.A.M, Grauls, Gert, Bruggeman, Cathrien A, Stassen, Frank R.M

“…Abstract Inspired by the suggested associations between neurological diseases and infections, we determined the susceptibility of brain cells to Chlamydia…”
Get full text

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease by Benedikter, Birke J., Wouters, Emiel F. M., Savelkoul, Paul H. M., Rohde, Gernot G. U., Stassen, Frank R. M.

“…Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses…”
Get full text

Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease by Vainas, Tryfon, Stassen, Frank R.M., Bruggeman, Cathrien A., Welten, Rob J. Th. J., van den Akker, Luc H.J.M., Kitslaar, Peter J.E.H.M., Peña, Amado S., Morré, Servaas A.

“…Genes involved in the regulation of immune responses, such as Toll-like receptor 4 (TLR4) and CD14, show genetic variations with potential functional…”
Get full text

Detection of amyloid beta aggregates in the brain of BALB/c mice after Chlamydia pneumoniae infection by Boelen, Ellen, Stassen, Frank R M, van der Ven, André J A M, Lemmens, Marijke A M, Steinbusch, Hellen P J, Bruggeman, Cathrien A, Schmitz, Christoph, Steinbusch, Harry W M

“…Neuroinflammation, initiated by cerebral infection, is increasingly postulated as an aetiological factor in neurodegenerative diseases such as Alzheimer's…”
Get full text

Effects of N-acetyl-L-cysteine on the membrane vesicle release and growth of respiratory pathogens by Volgers, Charlotte, Benedikter, Birke J, Grauls, Gert E, Hellebrand, Pauline H M, Savelkoul, Paul H M, Stassen, Frank R M

“…Bacterial infections contribute to the disease progression of chronic obstructive pulmonary disease by stimulating mucus production in the airways. This…”
Get full text

Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells by Volgers, Charlotte, Benedikter, Birke J., Grauls, Gert E., Savelkoul, Paul H.M., Stassen, Frank R.M.

“…[Display omitted] During infection, the release of nano-sized membrane vesicle is a process which is common both for bacteria and host cells. Host cell-derived…”
Get full text

Redox-dependent thiol modifications: implications for the release of extracellular vesicles by Benedikter, Birke J., Weseler, Antje R., Wouters, Emiel F. M., Savelkoul, Paul H. M., Rohde, Gernot G. U., Stassen, Frank R. M.

Get full text