Search Results - "FRANK, D. A"

Targeting the redox balance in inflammatory skin conditions by Wagener, Frank A D T G, Carels, Carine E, Lundvig, Ditte M S

“…Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS…”
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Novel Synthetic Polymer-Based 3D Contraction Assay: A Versatile Preclinical Research Platform for Fibrosis by Kumari, Jyoti, Wagener, Frank A. D. T. G, Kouwer, Paul H. J

“…The driving factors causing fibrosis and scar formation include fibroblast differentiation into myofibroblasts and hampered myofibroblast apoptosis, which…”
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Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections by Wagener, Frank A D T G, Pickkers, Peter, Peterson, Stephen J, Immenschuh, Stephan, Abraham, Nader G

“…SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are…”
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Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model by Op 't Veld, Roel C, Joosten, Lieke, Laverman, Peter, Bronkhorst, Ewald M, Jansen, John A, Walboomers, X Frank, Wagener, Frank A D T G

“…Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on…”
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk by Leonhardt, Julia, Dorresteijn, Mirrin J, Neugebauer, Sophie, Mihaylov, Diana, Kunze, Julia, Rubio, Ignacio, Hohberger, Frank-Stephan, Leonhardt, Silke, Kiehntopf, Michael, Stahl, Klaus, Bode, Christian, David, Sascha, Wagener, Frank A D T G, Pickkers, Peter, Bauer, Michael

“…Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying…”
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Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing by Wang, Zhihao, Knight, Rob, Stephens, Phil, Ongkosuwito, E M, Wagener, Frank A D T G, Von den Hoff, Johannes W

“…Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality…”
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Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores-A Clinical Study by Naik, Piyu Parth, Mossialos, Dimitris, Wijk, Bas van, Novakova, Petra, Wagener, Frank A D T G, Cremers, Niels A J

“…Cold sores are nasolabial blisters caused by herpes simplex virus (HSV) infections. Novel therapies demonstrating simultaneously antiviral activity and…”
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Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication by Pleeging, Carlos C F, Coenye, Tom, Mossialos, Dimitris, de Rooster, Hilde, Chrysostomou, Daniela, Wagener, Frank A D T G, Cremers, Niels A J

“…Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for…”
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The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus by Dekker, Douwe, Dorresteijn, Mirrin J, Pijnenburg, Margot, Heemskerk, Suzanne, Rasing-Hoogveld, Anja, Burger, David M, Wagener, Frank A.D.T.G, Smits, Paul

“…OBJECTIVE—In type 2 diabetes mellitus (T2DM), oxidative stress gives rise to endothelial dysfunction. Bilirubin, a powerful endogenous antioxidant,…”
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An Improved Understanding of the Pathophysiology of Pelvic Organ Prolapse: A 3D In Vitro Model under Static and Mechanical Loading Conditions by Velthoven, Melissa J. J., Gudde, Aksel N., Kruit, Marit, Loon, Malou P. C., Rasing, Lissy, Wagener, Frank A. D. T. G., Roovers, Jan‐Paul, Guler, Zeliha, Kouwer, Paul H. J.

“…The suboptimal outcomes of pelvic organ prolapse (POP) surgery illustrate the demand for improved therapies. However, their development is hampered by the…”
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STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas by WALKER, S. R, NELSON, E. A, FRANK, D. A

“…Deregulated expression of BCL6 is a pathogenic event in many lymphomas. BCL6 blocks cellular differentiation by repressing transcription of its target genes,…”
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Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors by Raterman, S. T., Metz, J. R., Wagener, Frank A. D. T. G., Von den Hoff, Johannes W.

“…The zebrafish is an appealing model organism for investigating the genetic (G) and environmental (E) factors, as well as their interactions (GxE), which…”
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Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice by Suttorp, Christiaan M, van Rheden, René E M, van Dijk, Natasja W M, Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Wagener, Frank A D T G

“…Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when…”
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Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells by Cremers, Niels A J, Lundvig, Ditte M S, van Dalen, Stephanie C M, Schelbergen, Rik F, van Lent, Peter L E M, Szarek, Walter A, Regan, Raymond F, Carels, Carine E, Wagener, Frank A D T G

“…Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered…”
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Different Faces of the Heme-Heme Oxygenase System in Inflammation by Wagener, Frank A D T G, Volk, Hans-Dieter, Willis, Dean, Abraham, Nader G, Soares, Miguel P, Adema, Gosse J, Figdor, Carl G

“…The heme-heme oxygenase system has recently been recognized to possess important regulatory properties. It is tightly involved in both physiological as well as…”
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Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? by Lundvig, Ditte M S, Immenschuh, Stephan, Wagener, Frank A D T G

“…Upon injury, prolonged inflammation and oxidative stress may cause pathological wound healing and fibrosis, leading to formation of excessive scar tissue…”
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Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue by Wever, Kimberley E, Wagener, Frank A D T G, Frielink, Cathelijne, Boerman, Otto C, Scheffer, Gert J, Allison, Anthony, Masereeuw, Rosalinde, Rongen, Gerard A

“…Renal ischemia/reperfusion injury (IRI) frequently complicates shock, renal transplantation and cardiac and aortic surgery, and has prognostic significance…”
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Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis by Scharstuhl, Alwin, Mutsaers, Henricus A M, Pennings, Sebastiaan W C, Russel, Frans G M, Wagener, Frank A D T G

“…We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated…”
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Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome by Wijnsma, Kioa L, Veissi, Susan T, de Wijs, Sem, van der Velden, Thea, Volokhina, Elena B, Wagener, Frank A D T G, van de Kar, Nicole C A J, van den Heuvel, L P

“…Shiga-toxin (Stx)-producing hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial…”
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Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury by Rosero Salazar, Doris H, van Rheden, René E M, van Hulzen, Manon, Carvajal Monroy, Paola L, Wagener, Frank A D T G, Von den Hoff, Johannes W

“…This study aimed to analyze the effects of fibrin constructs enhanced with laminin-nidogen, implanted in the wounded rat soft palate. Fibrin constructs with…”
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