Search Results - "FRA, Joaquin"

Randomized Phase II Study Comparing Gemcitabine Plus Dacarbazine Versus Dacarbazine Alone in Patients With Previously Treated Soft Tissue Sarcoma: A Spanish Group for Research on Sarcomas Study by GARCIA-DEL-MURO, Xavier, LOPEZ-POUSA, Antonio, MEANA, Andrés, PERICAY, Carlos, CUBEDO, Ricardo, RUBIO, Jordi, DE JUAN, Ana, LAINEZ, Nuria, ANTONIO CARRASCO, Juan, DE ANDRES, Raquel, BUESA, Jose M, MAUREL, Joan, MARTIN, Javier, MARTINEZ-TRUFERO, Javier, CASADO, Antonio, GOMEZ-ESAANA, Auxiliadora, FRA, Joaquin, CRUZ, Josefina, POVEDA, Andres

“…To assess the activity and toxicity of the combination of gemcitabine plus dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (STS) in a…”
Get full text

Sorting Transcriptomics Immune Information from Tumor Molecular Features Allows Prediction of Response to Anti-PD1 Therapy in Patients with Advanced Melanoma by Trilla-Fuertes, Lucía, Gámez-Pozo, Angelo, Prado-Vázquez, Guillermo, López-Vacas, Rocío, Zapater-Moros, Andrea, López-Camacho, Elena, Lumbreras-Herrera, María I, Soriano, Virtudes, Garicano, Fernando, Lecumberri, Mª José, Rodríguez de la Borbolla, María, Majem, Margarita, Pérez-Ruiz, Elisabeth, González-Cao, María, Oramas, Juana, Magdaleno, Alejandra, Fra, Joaquín, Martín-Carnicero, Alfonso, Corral, Mónica, Puértolas, Teresa, Ramos, Ricardo, Fresno Vara, Juan Ángel, Espinosa, Enrique

“…Immunotherapy based on anti-PD1 antibodies has improved the outcome of advanced melanoma. However, prediction of response to immunotherapy remains an unmet…”
Get full text

Multi-omics Characterization of Response to PD-1 Inhibitors in Advanced Melanoma by Trilla-Fuertes, Lucía, Gámez-Pozo, Angelo, Prado-Vázquez, Guillermo, López-Vacas, Rocío, Soriano, Virtudes, Garicano, Fernando, Lecumberri, M. José, Rodríguez de la Borbolla, María, Majem, Margarita, Pérez-Ruiz, Elisabeth, González-Cao, María, Oramas, Juana, Magdaleno, Alejandra, Fra, Joaquín, Martín-Carnicero, Alfonso, Corral, Mónica, Puértolas, Teresa, Ramos-Ruiz, Ricardo, Dittmann, Antje, Nanni, Paolo, Fresno Vara, Juan Ángel, Espinosa, Enrique

“…Immunotherapy improves the survival of patients with advanced melanoma, 40% of whom become long-term responders. However, not all patients respond to…”
Get full text

Inhaled corticosteroids may have a protective effect against coronavirus infection by Armentia, Alicia, Cortés, Sara Fernández, Simón, Angela Moro, Martín-Armentia, Blanca, Martín-Armentia, Sara, Pollo, Daniel Ramos, Cañadas, Juan Claudio Navarro, Caño, Javier Visa, Rubiales, Álvaro Sanz, Fra, Joaquín Rodriguez, Vaquero, Sara García, Pazos, Marta Cano, de la Calle, Jesús Galán, Lowell, Edgardo Raul, Soto, Cristina Crespo, Toledano, Carmen Sánchez, Salgado, Aurora Sacristán

“…Spain has been severely affected by the COVID-19 epidemic, with 195,944 persons infected and 20,453 deaths at the time of writing. Older people with…”
Get more information

Efficacy of Sequential High-Dose Doxorubicin and Ifosfamide Compared With Standard-Dose Doxorubicin in Patients With Advanced Soft Tissue Sarcoma: An Open-Label Randomized Phase II Study of the Spanish Group for Research on Sarcomas by Maurel, Joan, López-Pousa, Antonio, de las Peñas, Ramón, Fra, Joaquín, Martín, Javier, Cruz, Josefina, Casado, Antonio, Poveda, Andrés, Martínez-Trufero, Javier, Balañá, Carmen, Gómez, María Auxiliadora, Cubedo, Ricardo, Gallego, Oscar, Rubio-Viqueira, Belen, Rubió, Jordi, Andrés, Raquel, Sevilla, Isabel, de la Cruz, Juan Jose, del Muro, Xavier García, Buesa, Jose María

“…To assess the progression-free survival (PFS) and antitumor response to standard-dose doxorubicin compared with sequential dose-dense doxorubicin and…”
Get full text

Gemcitabine and vinorelbine (GV) versus cisplatin, gemcitabine and vinorelbine (CGV) as first-line treatment in advanced non small cell lung cancer: results of a prospective randomized phase II study by Esteban, Emilio, Fra, Joaquin, Fernández, Yolanda, Corral, Norberto, Vieitez, José M, Palacio, Isabel, de Sande, José L, Fernández, José L, Muñiz, Isabel, Villanueva, Noemi, Estrada, Enrique, Mareque, Beatriz, Uña, Esther, Buesa, José M, Lacave, Angel J

“…The objective of this study was to assess whether adding cisplatin to gemcitabine/vinorelbine combination improves the clinical outcome in patients with…”
Get full text

Role of Surgery in Patients with Recurrent, Metastatic, or Unresectable Locally Advanced Gastrointestinal Stromal Tumors Sensitive to Imatinib: A Retrospective Analysis of the Spanish Group for Research on Sarcoma (GEIS) by Rubió-Casadevall, Jordi, Martinez-Trufero, Javier, Garcia-Albeniz, Xabier, Calabuig, Silvia, Lopez-Pousa, Antonio, del Muro, Javier Garcia, Fra, Joaquin, Redondo, Andrés, Lainez, Nuria, Poveda, Andrés, Valverde, Claudia, De Juan, Ana, Sevilla, Isabel, Casado, Antonio, Andres, Raquel, Cruz, Josefina, Martin-Broto, Javier, Maurel, Joan

“…Background Recurrent, metastatic, and locally advanced gastrointestinal stromal tumors (GISTs) can be treated successfully with imatinib mesylate. Surgery for…”
Get full text

18F-FDG PET/CT of Lung Adenocarcinoma With Ovarian Metastases by García-Talavera, Paloma, Colinas, Daniel, Tamayo, Pilar, Fra, Joaquin, Montes, Arnold

“…ABSTRACTPatient was a 52-year-old woman with medical history of lung adenocarcinoma operated in 2009 (stage I, T2 N0 M0), showing increasing levels of tumor…”
Get full text

Pegylated liposomal doxorubicin and gemcitabine in a fixed dose rate infusion for the treatment of patients with poor prognosis of recurrent ovarian cancer: a phase Ib study by Crespo, Guillermo, Sierra, Marta, Losa, Raquel, Berros, José Pablo, Villanueva, Noemí, Fra, Joaquín, Fonseca, Paula J, Luque, María, Fernández, Yolanda, Blay, Pilar, Sanmamed, Miguel, Muriel, Carolina, Esteban, Emilio, Lacave, Angel J

“…Pegylated liposomal doxorubicin (PLD) is currently the reference treatment for platinum-resistant ovarian cancer. The combination of PLD and gemcitabine and…”
Get more information

Abstract 5416: RNA-seq and proteomics to identify response to immunotherapy in advanced melanoma: a Spanish Melanoma Group Study by Trilla-Fuertes, Lucia, Prado-Vazquez, Guillermo, Gámez-Pozo, Angelo, Lopez-Vacas, Rocio, Herrera, Maria Isabel Lumbreras, Soriano, Virtudes, Garicano, Fernando, Lecumberri, Maria Jose, Rodriguez, Maria, Majem, Margarita, Perez, Elisabeth, Gonzalez-Cao, Maria, Oramas, Juana, Magdaleno, Alejandra, Fra, Joaquin, Martin, Alfonso, Corral, Monica, Puertolas, Teresa, Vara, Juan Angel Fresno, Espinosa, Enrique

“…Abstract Background: Prediction of response to immunotherapy remains an unmet need in the field of advanced melanoma. Methods: Computational analyses,…”
Get full text

An ethical Response in the Care of Nursing Homes in the COVID-19 Pandemic

“…With the arrival of the COVID-19 pandemic, the risk of a possible lack of care for the elderly in nursing homes became evident. We summarize the experience of…”
Get full text

Phase I clinical trial of fixed–dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation by Buesa, José M., Losa, Raquel, Fernández, Aida, Sierra, Marta, Esteban, Emilio, Díaz, Ángela, López‐Pousa, Antonio, Fra, Joaquín

“…BACKGROUND In the current study, the authors set out to determine the dose‐limiting toxicity (DLT) and maximum tolerated dose (MTD) associated with a…”
Get full text

Phase II trial of ifosfamide in combination with sorafenib in patients with advanced soft tissue sarcoma: A Spanish Group for Research on Sarcomas (GEIS) study by Garcia del Muro, Xavier, Maurel, Joan, Martinez Trufero, Javier, Lavernia, Javier, Lopez-Pousa, Antonio, De Las Penas, Ramon, Cubedo, Ricardo, Fra, Joaquin, Casado, Antonio, De Juan, Ana, Jimenez Colomo, Laura, Martin Broto, Javier

“…Abstract only 10523 Background: Recent studies suggest that VEGFR inhibition could play a role in the treatment of soft tissue sarcoma (STS). Prior studies by…”
Get full text

Impact of the incorporation of tyrosine kinase inhibitor agents on the treatment of patients with a diagnosis of advanced renal cell carcinoma: study based on experience at the Hospital Universitario Central de Asturias by Muriel, Carolina, Esteban, Emilio, Corral, Norberto, Fonseca, Paula J., Luque, María, Berros, José Pablo, Fernández, Yolanda, Blay, Pilar, Fra, Joaquín, Villanueva, Noemí, Sanmamed, Miguel, Pardo, Pablo, Izquierdo, Marta, Vieitez, José María, Estrada, Enrique, Lacave, Ángel J.

“…Introduction For nearly the past two decades, cytokines (CKs) have been the only systemic treatment option available for advanced renal cell carcinoma (RCC)…”
Get full text

Sequential dose-dense doxorubicin and ifosfamide for advanced soft tissue sarcomas: A Phase II trial by the Spanish Group for Research on Sarcomas (GEIS) by MAUREL, Joan, FRA, Joaquin, LOPEZ-POUSA, Antonio, GARCIA DEL MURO, Xavier, BALANA, Carmen, CASADO, Antonio, MARTIN, Javier, MARTINEZ-TRUFERO, Javier, DE LAS PENAS, Ramon, BUESA, José M

“…Combinations of high-dose ifosfamide (IF; 10-12 g/m2) plus doxorubicin (DX; 50-90 mg/m2) have been administered to patients with advanced soft tissue sarcoma…”
Get full text

Analysis of the p38MAPK pathway in the prognosis of patients with surgically resected stage I-II NSCLC by Pardo-Coto, Pablo, Esteban, Emilio, Astudillo, Aurora, Gracia, Jose Manuel, Corral, Norberto, Izquierdo Manuel, Marta, Lopez, Carolina Muriel, Sanmamed, Miguel F., Gutierrez Restrepo, Eduardo, Valle Pereda, Miguel, Alvarez Fernandez, Carlos, Pérez Arnillas, Quionia, Berros Fombella, Jose Pablo, Jiménez, Paula, Vieitez de Prado, Jose Maria, Fra, Joaquin

“…Abstract only e18513 Background: TNM staging is the most important prognostic factor in Non-Small Cell Lung Cancer (NSCLC). The MAPK pathway, including p38,…”
Get full text

Phase II study of neoadjuvant high-dose ifosfamide with concurrent radiotherapy followed by surgical resection in high-risk soft tissue sarcoma: A Spanish Group for Research on Sarcomas (GEIS) study by Garcia del Muro, Xavier, Lopez-Pousa, Antonio, Flor, Maria Jose, Redondo, Andrés, Jurado, Josefina Cruz, Andres, Raquel, Casado, Antonio, Fra, Joaquin, Lopez-Martin, Jose A., Maurel, Juan, Valverde, Claudia María, Gallego, Oscar, Narvaez, Jose Antonio, Bague, Silvia, Sanjuan, Xavier, Vinyals, Juan M

“…Abstract only 10052 Background: High-dose ifosfamide (HDI) has shown promising activity as single agent in first-line chemotherapy for advanced soft tissue…”
Get full text

Abstract PO-005: Spatio-temporal geographical molecular mapping of primary papillary thyroid carcinomas and paired distant metastases: Clinical relevance for monitoring and targeting tumor heterogeneity by Gil, Sara, Estébanez, José Javier, Féas, Noa, Fra, Joaquín, Garcia-Rostán, Ginesa María

“…Abstract Approximately 15% of papillary thyroid carcinomas (PTCs) develop distant metastases (DMs). Little is known about the genetic alterations that underlie…”
Get full text

Activity of topotecan given intravenously for 5 days every three weeks in patients with advanced non-small cell lung cancer pretreated with platinum and taxanes: a phase II study by Gonzalez, Emilio Esteban, Villanueva, Noemi, Fra, Joaquin, Berros, Jose Pablo, Jimenez, Paula, Luque, María, Muñiz, Isabel, Blay, Pilar, Fernandez, Yolanda, Vieitez, José María, Muriel, Carolina, Sanmamed, Miguel, Coto, Pablo Pardo, Izquierdo, Marta, Estrada, Enrique, Lacave, Angel J.

“…Summary Topotecan, a semi-synthetic camptothecin analogue with topoisomerase I interaction, has shown to be an active agent in the treatment of advanced…”
Get full text

Sequential dose‐dense doxorubicin and ifosfamide for advanced soft tissue sarcomas by Maurel, Joan, Fra, Joaquín, López‐Pousa, Antonio, García del Muro, Xavier, Balañá, Carmen, Casado, Antonio, Martín, Javier, Martínez‐Trufero, Javier, de las Peñas, Ramón, Buesa, José M.

“…BACKGROUND Combinations of high‐dose ifosfamide (IF; 10–12 g/m2) plus doxorubicin (DX; 50–90 mg/m2) have been administered to patients with advanced soft…”
Get full text