Search Results - "FOX, W. M"

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation by Ojo, Kayode K., Eastman, Richard T., Vidadala, RamaSubbaRao, Zhang, Zhongsheng, Rivas, Kasey L., Choi, Ryan, Lutz, Justin D., Reid, Molly C., Fox, Anna M. W., Hulverson, Matthew A., Kennedy, Mark, Isoherranen, Nina, Kim, Laura M., Comess, Kenneth M., Kempf, Dale J., Verlinde, Christophe L. M. J., Su, Xin-zhuan, Kappe, Stefan H. I., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C.

“…Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in reducing or eliminating malaria in endemic regions. Here, we…”
Get full text

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds by Crowther, Gregory J, Hillesland, Heidi K, Keyloun, Katelyn R, Reid, Molly C, Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E, He, Panqing, Jones, Jackson C, Krahn, Mallory M, Mo, Jack S, Dasari, Kartheek S, Fox, Anna M W, Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L, Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K

“…In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds'…”
Get full text

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 by Larson, Eric T, Ojo, Kayode K, Murphy, Ryan C, Johnson, Steven M, Zhang, Zhongsheng, Kim, Jessica E, Leibly, David J, Fox, Anna M. W, Reid, Molly C, Dale, Edward J, Perera, B. Gayani K, Kim, Jae, Hewitt, Stephen N, Hol, Wim G. J, Verlinde, Christophe L. M. J, Fan, Erkang, Van Voorhis, Wesley C, Maly, Dustin J, Merritt, Ethan A

“…Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptosporidium parvum are a major health concern. The life cycle of these parasites is…”
Get full text

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity by Johnson, Steven M, Murphy, Ryan C, Geiger, Jennifer A, DeRocher, Amy E, Zhang, Zhongsheng, Ojo, Kayode K, Larson, Eric T, Perera, B. Gayani K, Dale, Edward J, He, Panqing, Reid, Molly C, Fox, Anna M. W, Mueller, Natascha R, Merritt, Ethan A, Fan, Erkang, Parsons, Marilyn, Van Voorhis, Wesley C, Maly, Dustin J

“…Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite Toxoplasma gondii. Proliferation of T. gondii is dependent on…”
Get full text

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis by Castellanos-Gonzalez, Alejandro, White, A. Clinton, Ojo, Kayode K., Vidadala, Rama S. R., Zhang, Zhongsheng, Reid, Molly C., Fox, Anna M. W., Keyloun, Katelyn R., Rivas, Kasey, Irani, Ayesha, Dann, Sara M., Fan, Erkang, Maly, Dustin J., Van Voorhis, Wesley C.

“…Cryptosporidium parasites infect intestinal cells, causing cryptosporidiosis. Despite its high morbidity and association with stunting in the developing world,…”
Get full text

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors by Ojo, Kayode K, Pfander, Claudia, Mueller, Natascha R, Burstroem, Charlotte, Larson, Eric T, Bryan, Cassie M, Fox, Anna M W, Reid, Molly C, Johnson, Steven M, Murphy, Ryan C, Kennedy, Mark, Mann, Henning, Leibly, David J, Hewitt, Stephen N, Verlinde, Christophe L M J, Kappe, Stefan, Merritt, Ethan A, Maly, Dustin J, Billker, Oliver, Van Voorhis, Wesley C

“…Effective control and eradication of malaria will require new tools to prevent transmission. Current antimalarial therapies targeting the asexual stage of…”
Get full text

The natural history and management of symptomatic and asymptomatic vertebral hemangiomas by FOX, M. W, ONOFRIO, B. M

“…Fifty-nine cases of vertebral hemangioma were seen at the Mayo Clinic between 1980 and 1990. Vertebral hemangiomas were discovered incidentally in 35 patients,…”
Get full text

The organochlorine contamination history of the Mersey estuary, UK, revealed by analysis of sediment cores from salt marshes by Fox, W.M, Connor, L, Copplestone, D, Johnson, M.S, Leah, R.T

“…Sediment profiles in the Banks, Ince and Widnes Warth salt marshes in Northwest England contain a mappable record of historic pollution. For persistent…”
Get full text

Clinical outcomes and radiological instability following decompressive lumbar laminectomy for degenerative spinal stenosis : a comparison of patients undergoing concomitant arthrodesis versus decompression alone by FOX, M. W, ONOFRIO, B. M, HANSSEN, A. D

“…One hundred twenty-four patients with degenerative lumbar stenosis underwent decompression with fusion (32 patients) and without fusion (92 patients) during a…”
Get full text

Neurological complications of ankylosing spondylitis by FOX, M. W, ONOFRIO, B. M, KILGORE, J. E

“…Thirty-three patients with ankylosing spondylitis with or without spinal neurological symptoms requiring surgical intervention were identified in a…”
Get full text

Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinson's disease patients by FOX, M. W, AHLSKOG, J. E, KELLY, P. J

“…Thirty-six patients with Parkinson's disease and medically refractory tremor underwent stereotactic ventrolateralis thalamotomy at the Mayo Clinic between 1984…”
Get full text

Peripheral nerve hemangioblastoma by Giannini, C, Scheithauer, B W, Hellbusch, L C, Rasmussen, A G, Fox, M W, McCormick, S R, Davis, D H

“…Capillary hemangioblastoma (HB) is a benign, highly vascular tumor limited almost exclusively to the central nervous system (CNS). It occurs primarily in the…”
Get more information

Thinks profession needs more holistic approach by Fox, M W

Get full text

Believes decreased dietary intake would reduce flatulence in dogs by Fox, M W

Get full text

Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody by Hameed, A, Olsen, KJ, Cheng, L, Fox, WM, 3d, Hruban, RH, Podack, ER

“…Perforin is a potent cytolytic pore-forming protein expressed in cytoplasmic granules of cytotoxic T lymphocytes and natural killer cells. A new monoclonal…”
Get full text

Anterolateral decompression of the atlantoaxial vertebral artery for symptomatic positional occlusion of the vertebral artery. Case report by Fox, M W, Piepgras, D G, Bartleson, J D

“…A case of repeated vertebrobasilar ischemic attacks related to head rotation (bow hunter's stroke) is reported. With head rotation of 45 degrees or more to the…”
Get full text

The use of sediment cores from stable and developing salt marshes to reconstruct historical contamination profiles in the Mersey Estuary, UK by FOX, W. M, JOHNSON, M. S, JONES, S. R, LEAH, R. T, COPPLESTONE, D

“…Researchers evaluated depth-profile sediment cores from two marshes in the Mersey Estuary for their contents of cesium 137, plutonium 238, plutonium 239-240,…”
Get full text

Applauds increased regulation of antimicrobials by Fox, M W

Get more information

Feasibility of international somatic cell count standards by Fox, M W

Get more information

Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines by Miskovsky, EP, Liu, AY, Pavlat, W, Viveen, R, Stanhope, PE, Finzi, D, Fox, WM, 3rd, Hruban, RH, Podack, ER, Siliciano, RF

“…Vaccine-induced, virus-specific CTLs may rapidly eliminate the host cells that first become infected after virus exposure, thereby preventing disseminated…”
Get full text